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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342518
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC22A2
Name: solute carrier family 22 member 2
Acc ID: CHEBI:4975
Term: famotidine
Definition: A guanidine that has formula C8H15N7O2S3.
Chemical ID: MESH:D015738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC22A2increases uptakeEXP 6480464CTDSLC22A2 protein results in increased uptake of FamotidinePMID:16006492
SLC22A2multiple interactionsEXP 6480464CTDFamotidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Famotidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Famotidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]PMID:15496291 PMID:16141367 PMID:21599003
SLC22A2increases uptakeISOSlc22a2 (Rattus norvegicus)6480464CTDSLC22A2 protein results in increased uptake of FamotidinePMID:16006492
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