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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332548
Species: Mus musculus
RGD Object: Gene
Symbol: Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Acc ID: CHEBI:30052
Term: copper(0)
Definition: An elemental copper that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1adecreases expressionISOPpargc1a (Rattus norvegicus)6480464CTDCopper results in decreased expression of PPARGC1A mRNAPMID:22465980
Ppargc1aincreases expressionISOPpargc1a (Rattus norvegicus)6480464CTDCopper deficiency results in increased expression of PPARGC1A mRNA; Copper deficiency results in increased expression of PPARGC1A proteinPMID:18993053
Ppargc1amultiple interactionsISOPPARGC1A (Homo sapiens)6480464CTD[Chelating Agents binds to Copper] which results in decreased expression of PPARGC1A mRNAPMID:31162603
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