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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332416
Species: Mus musculus
RGD Object: Gene
Symbol: Vkorc1
Name: vitamin K epoxide reductase complex, subunit 1
Acc ID: CHEBI:80742
Term: Coumatetralyl
Definition: A hydroxycoumarin that has formula C19H16O3.
Chemical ID: MESH:C004699
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vkorc1decreases response to substanceEXP 6480464CTDVKORC1 protein polymorphism results in decreased susceptibility to coumatetralylPMID:27117082
Vkorc1decreases activityISOVKORC1 (Homo sapiens)6480464CTDcoumatetralyl results in decreased activity of VKORC1 proteinPMID:29581108
Vkorc1decreases response to substanceISOVkorc1 (Rattus norvegicus)6480464CTDVKORC1 protein polymorphism results in decreased susceptibility to coumatetralylPMID:27117082
Vkorc1multiple interactionsISOVKORC1 (Homo sapiens)6480464CTDcoumatetralyl inhibits the reaction [VKORC1 protein results in increased reduction of Vitamin K 1]PMID:29581108
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