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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332039
Species: Mus musculus
RGD Object: Gene
Symbol: Bace1
Name: beta-site APP cleaving enzyme 1
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bace1decreases expressionISOBace1 (Rattus norvegicus)6480464CTDLovastatin results in decreased expression of BACE1 proteinPMID:29341888
Bace1multiple interactionsISOBACE1 (Homo sapiens)6480464CTD[Lovastatin co-treated with APP protein] results in decreased expression of BACE1 proteinPMID:29341888
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