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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1319774
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2U1
Name: cytochrome P450 family 2 subfamily U member 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2U1decreases methylationEXP 6480464CTDbisphenol A results in decreased methylation of CYP2U1 genePMID:31601247
CYP2U1increases expressionEXP 6480464CTDbisphenol A results in increased expression of CYP2U1 mRNAPMID:29275510
CYP2U1decreases expressionISOCyp2u1 (Rattus norvegicus)6480464CTDbisphenol A results in decreased expression of CYP2U1 mRNAPMID:25181051 PMID:30816183 PMID:32528016 PMID:34947998
CYP2U1increases methylationISOCyp2u1 (Rattus norvegicus)6480464CTDbisphenol A results in increased methylation of CYP2U1 genePMID:28505145
CYP2U1multiple interactionsISOCyp2u1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of CYP2U1 mRNAPMID:28433925
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