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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318374
Species: Homo sapiens
RGD Object: Gene
Symbol: SIRT1
Name: sirtuin 1
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SIRT1decreases degradationEXP 6480464CTDsodium arsenite results in decreased degradation of SIRT1 mRNAPMID:24106086
SIRT1decreases expressionEXP 6480464CTDsodium arsenite results in decreased expression of SIRT1 mRNA; sodium arsenite results in decreased expression of SIRT1 proteinPMID:25982963 PMID:33360347
SIRT1increases expressionEXP 6480464CTDsodium arsenite results in increased expression of SIRT1 mRNAPMID:17879257 PMID:38568856
SIRT1multiple interactionsEXP 6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SIRT1 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SIRT1 protein; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein]; Folic Acid inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein]; INS protein inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein]; SHC1 protein inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein]; SIRT1 protein inhibits the reaction [sodium arsenite results in decreased expression of GDF1 protein]; SIRT1 protein inhibits the reaction [sodium arsenite results in decreased expression of SP1 protein]; SIRT1 protein inhibits the reaction [sodium arsenite results in increased expression of SHC1 protein]; sodium arsenite inhibits the reaction [SIRT1 protein binds to SHC1 promoter]; sodium arsenite inhibits the reaction [SP1 protein binds to SIRT1 promoter]; sodium arsenite promotes the reaction [ELAVL1 protein binds to and results in decreased degradation of SIRT1 mRNA]; SP1 protein affects the reaction [sodium arsenite results in decreased expression of SIRT1 protein]; Vitamin K 3 inhibits the reaction [sodium arsenite promotes the reaction [ELAVL1 protein binds to and results in decreased degradation of SIRT1 mRNA]]; Vitamin K 3 inhibits the reaction [sodium arsenite results in decreased degradation of SIRT1 mRNA]PMID:24106086 PMID:25982963 PMID:33360347 PMID:36669534
SIRT1decreases expressionISOSirt1 (Rattus norvegicus)6480464CTDsodium arsenite results in decreased expression of SIRT1 mRNA; sodium arsenite results in decreased expression of SIRT1 proteinPMID:33360347
SIRT1decreases expressionISOSirt1 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of SIRT1 mRNA; sodium arsenite results in decreased expression of SIRT1 proteinPMID:25610880
SIRT1increases expressionISOSirt1 (Mus musculus)6480464CTDsodium arsenite results in increased expression of SIRT1 mRNAPMID:19822182 PMID:34968464
SIRT1multiple interactionsISOSirt1 (Rattus norvegicus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SIRT1 protein; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of SIRT1 protein]; Melatonin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SIRT1 protein]PMID:33360347 PMID:35598369 PMID:38229313
SIRT1multiple interactionsISOSirt1 (Mus musculus)6480464CTD[DOT1L protein affects the susceptibility to sodium arsenite] which results in decreased expression of SIRT1 mRNA; [sodium arsenite co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of SIRT1 mRNA; Palmitic Acid inhibits the reaction [sodium arsenite results in increased expression of SIRT1 mRNA]; Palmitic Acid promotes the reaction [[sodium arsenite co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of SIRT1 mRNA]; sodium arsenite inhibits the reaction [Palmitic Acid results in increased expression of SIRT1 mRNA]; sodium arsenite promotes the reaction [[Palmitic Acid co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of SIRT1 mRNA]PMID:30130555 PMID:34968464
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