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GENE - TERM ANNOTATION REPORT

RGD ID: 1312037
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Psenen
Name: presenilin enhancer gamma secretase subunit
Acc ID: GO:0070765
Term: gamma-secretase complex
Definition: A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.
Definition Source(s): GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Psenenlocated_inISOPSENEN (Homo sapiens)1624291RGD PMID:26280335

PMID:26280335
Psenenpart_ofISOPSENEN (Homo sapiens)1624291RGDUniProtKB:P05067 UniProtKB:P49768 PMID:12763021 PMID:25043039 PMID:26280335

PMID:12763021 PMID:25043039 PMID:26280335
Psenenpart_ofISOPsenen (Mus musculus)1624291RGD PMID:16371134 PMID:16641999

PMID:16371134 PMID:16641999
Psenenpart_ofIBAFB:FBgn0053198 or MGI:1913590 or PANTHER:PTN000418972 or UniProtKB:Q9NZ421600115GO_CentralGO_REF:0000033

GO_REF:0000033
Psenenpart_ofISSUniProtKB:Q9NZ421600115UniProtGO_REF:0000024

GO_REF:0000024
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