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ONTOLOGY REPORT - ANNOTATIONS

Term:gamma-secretase complex
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Accession:GO:0070765 term browser browse the term
Definition:A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.
Synonyms:exact_synonym: presenilin complex
 narrow_synonym: CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant);   PS1 complex;   PS2 complex;   gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant);   gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN);   gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
 related_synonym: gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)


show annotations for term's descendants           Sort by:
gamma-secretase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aph1a aph-1 homolog A, gamma secretase subunit part_of
located_in		 ISO
IBA		 (PMID:12297508), (PMID:25043039), (PMID:26280335)
(PMID:26280335)
GO_REF:0000033		 RGD
GO_Central		 PMID:12297508 PMID:25043039 PMID:26280335 GO_REF:0000033 NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955 		JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit part_of ISO
IBA		 UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021)
GO_REF:0000033
MGI:1915568 (PMID:16371134), (PMID:18626010), (PMID:19299585)		 RGD
GO_Central		 PMID:12297508 PMID:12763021 PMID:16371134 PMID:18626010 PMID:19299585 GO_REF:0000033 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243 		JBrowse link
G Aph1bl2 aph-1 homolog B, gamma secretase subunit like 2 part_of IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 8:67,341,790...67,363,967
Ensembl chr 8:67,341,834...67,363,864
Ensembl chr 8:67,341,834...67,363,864 		JBrowse link
G Ncstn nicastrin part_of
located_in		 ISO
ISS		 UniProtKB:P05067|UniProtKB:P49768 (PMID:12297508), (PMID:12763021), (PMID:25043039), (PMID:26280335)
GO_REF:0000024
(PMID:26280335)
(PMID:16371134), (PMID:16641999), (PMID:20674680)		 RGD
UniProt		 PMID:12297508 PMID:12763021 PMID:16371134 PMID:16641999 PMID:20674680 More... GO_REF:0000024 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Psen1 presenilin 1 part_of ISO
ISS
IBA		 UniProtKB:P05067 (PMID:10801983), (PMID:12297508), (PMID:12763021), (PMID:26280335)
GO_REF:0000024
GO_REF:0000033
(PMID:12684521), (PMID:16371134), (PMID:16641999), (PMID:20674680)		 RGD
UniProt
GO_Central		 PMID:10801983 PMID:12297508 PMID:12684521 PMID:12763021 PMID:16371134 More... GO_REF:0000024 GO_REF:0000033 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 part_of ISO
IBA		 (PMID:12297508)
GO_REF:0000033
(PMID:12684521)		 RGD
GO_Central		 PMID:12297508 PMID:12684521 GO_REF:0000033 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Psenen presenilin enhancer gamma secretase subunit part_of
located_in		 ISS
ISO
IBA		 GO_REF:0000024
UniProtKB:P05067|UniProtKB:P49768 (PMID:12763021), (PMID:25043039), (PMID:26280335)
(PMID:26280335)
GO_REF:0000033
(PMID:16371134), (PMID:16641999)		 UniProt
RGD
GO_Central		 PMID:12763021 PMID:16371134 PMID:16641999 PMID:25043039 PMID:26280335 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192 		JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 part_of IDA
ISO
IEA		 (PMID:16641999)
GO_REF:0000107		 RGD
Ensembl		 PMID:16641999 PMID:19754663 GO_REF:0000107, RGD:2317342 NCBI chr 6:104,991,843...105,026,705
Ensembl chr 6:104,991,838...105,026,753 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 21392
    protein-containing complex 6987
      catalytic complex 1938
        gamma-secretase complex 8
Path 2
Term Annotations click to browse term
  cellular_component 21392
    cellular anatomical entity 21234
      membrane 10503
        plasma membrane 6621
          plasma membrane protein complex 654
            gamma-secretase complex 8
paths to the root