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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
1,3-beta-D-glucan synthase complex 
1-alkyl-2-acetylglycerophosphocholine esterase complex  
2-iminoacetate synthase complex 
3-isopropylmalate dehydratase complex 
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex 
[Ni-Fe] hydrogenase complex 
acetyl-CoA carboxylase complex +   
acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex 
acyl-CoA ceramide synthase complex 
ADPG pyrophosphorylase complex +  
alpha1-beta1 integrin-alpha3(VI) complex 
alpha1-beta1 integrin-tissue transglutaminase complex 
alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex 
alpha11-beta1 integrin-collagen type I complex 
alpha2-beta1 integrin-alpha3(VI) complex 
alpha2-beta1 integrin-CD47 complex 
alpha2-beta1 integrin-chondroadherin complex 
alpha3-beta1 integrin-basigin complex 
alpha3-beta1 integrin-CD151 complex 
alpha3-beta1 integrin-CD63 complex 
alpha3-beta1 integrin-thrombospondin complex 
alpha3-beta1 integrin-tissue transglutaminase complex 
alpha4-beta1 integrin-CD47 complex 
alpha4-beta1 integrin-CD53 complex 
alpha4-beta1 integrin-CD63 complex 
alpha4-beta1 integrin-CD81 complex 
alpha4-beta1 integrin-CD82 complex 
alpha4-beta1 integrin-JAM2 complex 
alpha4-beta1 integrin-paxillin complex 
alpha4-beta1 integrin-thrombospondin-1 complex 
alpha4-beta1 integrin-thrombospondin-2 complex 
alpha4-beta4 integrin-EMILIN-1 complex 
alpha5-beta1 integrin-endostatin complex 
alpha5-beta1 integrin-fibronectin-NOV complex 
alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex 
alpha5-beta1 integrin-LPP3 complex 
alpha5-beta1 integrin-osteopontin complex 
alpha5-beta1 integrin-tissue transglutaminase complex 
alpha5-beta5-fibronectin-SFRP2 complex 
alpha6-beta1 integrin-CD151 complex 
alpha6-beta1 integrin-CYR61 complex 
alpha6-beta4 integrin-CD151 complex 
alpha6-beta4 integrin-CD9 complex 
alpha6-beta4 integrin-Fyn complex 
alpha6-beta4 integrin-laminin 5 complex 
alpha6-beta4 integrin-Shc-Grb2 complex 
alpha7-beta1 integrin-CD151 complex 
alpha7-beta1 integrin-focal adhesion kinase complex 
alpha7-beta1 integrin-laminin alpha-2 complex 
alpha7-beta1 integrin-nicotinamide riboside kinase complex 
alpha9-beta1 integrin-ADAM1 complex 
alpha9-beta1 integrin-ADAM12 complex 
alpha9-beta1 integrin-ADAM15 complex 
alpha9-beta1 integrin-ADAM2 complex 
alpha9-beta1 integrin-ADAM3 complex 
alpha9-beta1 integrin-ADAM8 complex  
alpha9-beta1 integrin-ADAM9 complex 
alpha9-beta1 integrin-osteopontin complex 
alpha9-beta1 integrin-tenascin complex 
alpha9-beta1 integrin-thrombospondin-1 complex 
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex  
alpha9-beta1 integrin-VEGF-A complex 
alpha9-beta1 integrin-VEGF-C complex 
alpha9-beta1 integrin-VEGF-D complex 
alphaE-beta7 integrin-E-cadherin complex 
alphaIIb-beta3 integrin-CD47-FAK complex 
alphaIIb-beta3 integrin-CD47-Src complex 
alphaIIb-beta3 integrin-CD9 complex 
alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex 
alphaIIb-beta3 integrin-CIB complex 
alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex 
alphaIIb-beta3 integrin-ICAM-4 complex 
alphaIIb-beta3 integrin-talin complex 
alphaM-beta2 integrin-CD63 complex 
alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex 
alphaPDGFR-SHP-2 complex 
alphav-beta1 integrin-osteopontin complex 
alphav-beta3 integrin-ADAM15 complex 
alphav-beta3 integrin-ADAM23 complex 
alphav-beta3 integrin-CD47 complex 
alphaV-beta3 integrin-CD47-FCER2 complex 
alphaV-beta3 integrin-CD98 complex 
alphav-beta3 integrin-collagen alpha3(VI) complex 
alphaV-beta3 integrin-EGFR complex 
alphaV-beta3 integrin-gelsolin complex 
alphav-beta3 integrin-HMGB1 complex  
alphav-beta3 integrin-IGF-1-IGF1R complex  
alphaV-beta3 integrin-laminin alpha-4 complex 
alphaV-beta3 integrin-LPP3 complex 
alphaV-beta3 integrin-NOV complex 
alphav-beta3 integrin-osteopontin complex 
alphaV-beta3 integrin-paxillin-Pyk2 complex 
alphav-beta3 integrin-PKCalpha complex  
alphav-beta3 integrin-thrombospondin complex 
alphaV-beta3 integrin-tissue transglutaminase complex 
alphaV-beta3 integrin-tumstatin complex 
alphav-beta3 integrin-vitronectin complex  
alphav-beta5 integrin-osteopontin complex 
alphav-beta5 integrin-vitronectin complex 
alphaV-beta6 integrin-osteopontin complex 
alphaV-beta6 integrin-TGFbeta-3 complex 
alphaV-beta8 integrin-MMP14-TGFbeta-1 complex 
alphaX-beta2 integrin-ICAM-4 complex 
amino acid transport complex  
aminoacyl-tRNA synthetase multienzyme complex  
aminodeoxychorismate synthase complex 
anaerobic ribonucleoside-triphosphate reductase complex 
anthranilate synthase complex 
AP-2 adaptor complex  
ATP-binding cassette (ABC) transporter complex +   
ATP-independent citrate lyase complex 
ATPase complex +   
auxin efflux carrier complex 
bacterial-type flagellum stator complex 
beta-catenin destruction complex  
beta-galactosidase complex 
beta-N-acetylhexosaminidase complex  
box H/ACA scaRNP complex  
box H/ACA snoRNP complex  
calcium- and calmodulin-dependent protein kinase complex  
carbamoyl-phosphate synthase complex  
carbon phosphorus lyase complex 
catalytic step 1 spliceosome +   
catalytic step 2 spliceosome +   
catenin complex  
caveolar macromolecular signaling complex  
CD19-Vav-PIK3R1 complex 
CD20-Lck-Fyn complex 
CD20-Lck-Lyn-Fyn complex 
CFTR-NHERF-ezrin complex 
ciliary necklace 
classical-complement-pathway C3/C5 convertase complex  
clathrin coat of coated pit +   
CoA-synthesizing protein complex 
connexin complex  
contractile vacuole pore 
CSK-GAP-A.p62 complex 
Cus cation efflux complex 
cytochrome complex +   
cytosolic tRNA wobble base thiouridylase complex  
D-amino-acid dehydrogenase complex 
death-inducing signaling complex +   
Delta1 complex 
DNA helicase complex +   
DNA ligase III-XRCC1 complex  
DNA repair complex +   
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex +   
dynein complex +   
dystrobrevin complex  
dystroglycan complex +   
dystrophin-associated glycoprotein complex +   
EFF-1 complex 
EGFR-Grb2-Sos complex 
EGFR-Shc-Grb2-Sos complex 
Elg1 RFC-like complex  
elongator holoenzyme complex  
EmrE multidrug transporter complex 
endonuclease complex +   
endopeptidase Clp complex +   
enterobactin synthetase complex 
ethanolamine ammonia-lyase complex 
exodeoxyribonuclease V complex 
exodeoxyribonuclease VII complex 
exoribonuclease complex +   
fatty acid beta-oxidation multienzyme complex +   
fatty acid synthase complex 
Fc receptor complex +   
fibronectin-tissue transglutaminase complex 
flotillin complex  
formyl-methanofuran dehydrogenase (molybdenum enzyme) complex 
formyl-methanofuran dehydrogenase (tungsten enzyme) complex 
fumarate reductase complex +   
gamma-secretase complex  
A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.
gamma-secretase-Delta1 complex 
GCH1 complex 
glucosidase complex +  
glucosidase II complex  
glutamate decarboxylase complex 
glutamate-cysteine ligase complex  
glutamate-tRNA ligase complex 
glutaminase complex 
glutamyl-tRNA(Gln) amidotransferase complex  
glutathione synthase complex 
glycine-gated chloride channel complex  
glycine-tRNA ligase complex 
Grb2-EGFR complex  
Grb2-Shc complex 
Grb2-SHP-2 complex 
Grb2-Sos complex  
GTPase complex +   
guanylate cyclase complex, soluble  
heparanase complex  
heterotrimeric G-protein complex  
high-affinity iron permease complex 
histamine-gated chloride channel complex 
histone deacetylase complex +   
hydroxyisourate hydrolase complex 
inaD signaling complex 
inhibin-betaglycan-ActRII complex  
interleukin-12-interleukin-12 receptor complex 
interleukin4-interleukin-4 receptor complex 
intramolecular phosphotransferase complex +  
invertasome 
inward rectifying potassium channel  
isoamylase complex +   
L-cysteine desulfurase complex +   
low-density lipoprotein receptor complex  
lysosomal multienzyme complex 
magnesium chelatase complex 
MalFGK2 complex 
mannosyl-oligosaccharide 1,2-alpha-mannosidase complex 
MdtBC Complex 
membrane attack complex  
methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex 
methylcrotonoyl-CoA carboxylase complex +   
MHC protein complex +   
mitochondrial inner membrane peptidase complex  
mitochondrial processing peptidase complex  
molybdopterin synthase complex  
MPP7-DLG1-LIN7 complex  
mRNA editing complex +   
NAD(P)H dehydrogenase complex (plastoquinone) +  
NADPH oxidase complex  
NarGHI complex 
nitrite reductase complex [NAD(P)H] 
nonsense-mediated decay complex 
ornithine carbamoyltransferase inhibitor complex 
Ost-alpha/Ost-beta complex 
oxidoreductase complex +   
peptidase complex +   
phenylalanine-tRNA ligase complex  
phosphatase complex +   
phosphoenolpyruvate-dependent sugar phosphotransferase complex 
phosphopantothenoylcysteine decarboxylase complex  
phosphopyruvate hydratase complex  
phosphoribosylaminoimidazole carboxylase complex 
plasma membrane fumarate reductase complex 
plasma membrane proton-transporting ATP synthase complex +  
plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) +  
plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) +  
plasma membrane proton-transporting ATP synthase, catalytic core 
plasma membrane proton-transporting ATP synthase, central stalk 
plasma membrane proton-transporting ATP synthase, stator stalk 
plasma membrane proton-transporting V-type ATPase complex +   
plasma membrane proton-transporting V-type ATPase, V0 domain 
plasma membrane proton-transporting V-type ATPase, V1 domain 
plasma membrane respiratory chain complex I 
plasma membrane respiratory chain complex II +  
plasma membrane respiratory chain complex III 
plasma membrane respiratory chain complex IV 
plasma membrane signaling receptor complex +   
plasma membrane succinate dehydrogenase complex +  
plasma membrane-derived photosystem I 
plasma membrane-derived thylakoid photosystem II 
plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex 
platelet-derived growth factor receptor-ligand complex 
polyketide synthase complex +  
potassium:proton exchanging ATPase complex  
proteasome core complex +   
protocadherin-alpha-protocadherin-gamma complex +  
pyrophosphate-dependent phosphofructokinase complex +  
pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex 
pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex 
RecQ family helicase-topoisomerase III complex  
respiratory chain complex II +   
ribonuclease H2 complex  
ribulose bisphosphate carboxylase complex +  
ripoptosome  
sarcoglycan complex  
SC5b-7 complex 
serine-tRNA ligase complex 
Shc-EGFR complex  
Shc-Grb2-Sos complex 
sodium:potassium-exchanging ATPase complex  
subapical complex  
sucrase-isomaltase complex 
sulfite reductase complex (NADPH) 
sulfopyruvate decarboxylase complex 
SUMO activating enzyme complex  
syntrophin complex  
TAT protein transport complex 
telomerase holoenzyme complex +   
thioglucosidase complex 
transferase complex +   
transmembrane collagen trimer +   
tricarboxylic acid cycle heteromeric enzyme complex +   
tRNA-specific adenosine-34 deaminase complex 
tRNA-splicing ligase complex  
ubiquitin activating enzyme complex 
UDP-N-acetylglucosamine transferase complex  
urease complex 
viral terminase, large subunit 
voltage-gated calcium channel complex +   
voltage-gated potassium channel complex +   
voltage-gated sodium channel complex  
Wnt-Frizzled-LRP5/6 complex  
xylanosome 

Synonyms
Exact Synonyms: presenilin complex
Narrow Synonyms: CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant) ;   PS1 complex ;   PS2 complex ;   gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant) ;   gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN) ;   gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
Related Synonyms: gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN)
Definition Sources: GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437

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