Parent Terms |
Term With Siblings |
Child Terms |
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1,3-beta-D-glucan synthase complex
1-alkyl-2-acetylglycerophosphocholine esterase complex
2-iminoacetate synthase complex
3-isopropylmalate dehydratase complex
7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex
[Ni-Fe] hydrogenase complex
acetyl-CoA carboxylase complex +
acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex
acyl-CoA ceramide synthase complex
ADPG pyrophosphorylase complex +
alpha1-beta1 integrin-alpha3(VI) complex
alpha1-beta1 integrin-tissue transglutaminase complex
alpha1-beta1 integrin-tyrosine-protein phosphatase non-receptor type 2 complex
alpha11-beta1 integrin-collagen type I complex
alpha2-beta1 integrin-alpha3(VI) complex
alpha2-beta1 integrin-CD47 complex
alpha2-beta1 integrin-chondroadherin complex
alpha3-beta1 integrin-basigin complex
alpha3-beta1 integrin-CD151 complex
alpha3-beta1 integrin-CD63 complex
alpha3-beta1 integrin-thrombospondin complex
alpha3-beta1 integrin-tissue transglutaminase complex
alpha4-beta1 integrin-CD47 complex
alpha4-beta1 integrin-CD53 complex
alpha4-beta1 integrin-CD63 complex
alpha4-beta1 integrin-CD81 complex
alpha4-beta1 integrin-CD82 complex
alpha4-beta1 integrin-JAM2 complex
alpha4-beta1 integrin-paxillin complex
alpha4-beta1 integrin-thrombospondin-1 complex
alpha4-beta1 integrin-thrombospondin-2 complex
alpha4-beta4 integrin-EMILIN-1 complex
alpha5-beta1 integrin-endostatin complex
alpha5-beta1 integrin-fibronectin-NOV complex
alpha5-beta1 integrin-fibronectin-tissue transglutaminase complex
alpha5-beta1 integrin-LPP3 complex
alpha5-beta1 integrin-osteopontin complex
alpha5-beta1 integrin-tissue transglutaminase complex
alpha5-beta5-fibronectin-SFRP2 complex
alpha6-beta1 integrin-CD151 complex
alpha6-beta1 integrin-CYR61 complex
alpha6-beta4 integrin-CD151 complex
alpha6-beta4 integrin-CD9 complex
alpha6-beta4 integrin-Fyn complex
alpha6-beta4 integrin-laminin 5 complex
alpha6-beta4 integrin-Shc-Grb2 complex
alpha7-beta1 integrin-CD151 complex
alpha7-beta1 integrin-focal adhesion kinase complex
alpha7-beta1 integrin-laminin alpha-2 complex
alpha7-beta1 integrin-nicotinamide riboside kinase complex
alpha9-beta1 integrin-ADAM1 complex
alpha9-beta1 integrin-ADAM12 complex
alpha9-beta1 integrin-ADAM15 complex
alpha9-beta1 integrin-ADAM2 complex
alpha9-beta1 integrin-ADAM3 complex
alpha9-beta1 integrin-ADAM8 complex
alpha9-beta1 integrin-ADAM9 complex
alpha9-beta1 integrin-osteopontin complex
alpha9-beta1 integrin-tenascin complex
alpha9-beta1 integrin-thrombospondin-1 complex
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex
alpha9-beta1 integrin-VEGF-A complex
alpha9-beta1 integrin-VEGF-C complex
alpha9-beta1 integrin-VEGF-D complex
alphaE-beta7 integrin-E-cadherin complex
alphaIIb-beta3 integrin-CD47-FAK complex
alphaIIb-beta3 integrin-CD47-Src complex
alphaIIb-beta3 integrin-CD9 complex
alphaIIb-beta3 integrin-CD9-CD47-platelet glycoprotein Ib complex
alphaIIb-beta3 integrin-CIB complex
alphaIIb-beta3 integrin-fibronectin-tissue transglutaminase complex
alphaIIb-beta3 integrin-ICAM-4 complex
alphaIIb-beta3 integrin-talin complex
alphaM-beta2 integrin-CD63 complex
alphaPDGFR-PLC-gamma-1-PI3K-SHP-2 complex
alphav-beta1 integrin-osteopontin complex
alphav-beta3 integrin-ADAM15 complex
alphav-beta3 integrin-ADAM23 complex
alphav-beta3 integrin-CD47 complex
alphaV-beta3 integrin-CD47-FCER2 complex
alphaV-beta3 integrin-CD98 complex
alphav-beta3 integrin-collagen alpha3(VI) complex
alphaV-beta3 integrin-EGFR complex
alphaV-beta3 integrin-gelsolin complex
alphav-beta3 integrin-HMGB1 complex
alphav-beta3 integrin-IGF-1-IGF1R complex
alphaV-beta3 integrin-laminin alpha-4 complex
alphaV-beta3 integrin-LPP3 complex
alphaV-beta3 integrin-NOV complex
alphav-beta3 integrin-osteopontin complex
alphaV-beta3 integrin-paxillin-Pyk2 complex
alphav-beta3 integrin-PKCalpha complex
alphav-beta3 integrin-thrombospondin complex
alphaV-beta3 integrin-tissue transglutaminase complex
alphaV-beta3 integrin-tumstatin complex
alphav-beta3 integrin-vitronectin complex
alphav-beta5 integrin-osteopontin complex
alphav-beta5 integrin-vitronectin complex
alphaV-beta6 integrin-osteopontin complex
alphaV-beta6 integrin-TGFbeta-3 complex
alphaV-beta8 integrin-MMP14-TGFbeta-1 complex
alphaX-beta2 integrin-ICAM-4 complex
amino acid transport complex
aminoacyl-tRNA synthetase multienzyme complex
aminodeoxychorismate synthase complex
anaerobic ribonucleoside-triphosphate reductase complex
anthranilate synthase complex
ATP-binding cassette (ABC) transporter complex +
ATP-independent citrate lyase complex
auxin efflux carrier complex
bacterial-type flagellum stator complex
beta-catenin destruction complex
beta-galactosidase complex
beta-N-acetylhexosaminidase complex
calcium- and calmodulin-dependent protein kinase complex
carbamoyl-phosphate synthase complex
carbon phosphorus lyase complex
catalytic step 1 spliceosome +
catalytic step 2 spliceosome +
caveolar macromolecular signaling complex
classical-complement-pathway C3/C5 convertase complex
clathrin coat of coated pit +
CoA-synthesizing protein complex
Cus cation efflux complex
cytosolic tRNA wobble base thiouridylase complex
D-amino-acid dehydrogenase complex
death-inducing signaling complex +
DNA ligase III-XRCC1 complex
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex +
dystrophin-associated glycoprotein complex +
EGFR-Shc-Grb2-Sos complex
elongator holoenzyme complex
EmrE multidrug transporter complex
endopeptidase Clp complex +
enterobactin synthetase complex
ethanolamine ammonia-lyase complex
exodeoxyribonuclease V complex
exodeoxyribonuclease VII complex
exoribonuclease complex +
fatty acid beta-oxidation multienzyme complex +
fatty acid synthase complex
fibronectin-tissue transglutaminase complex
formyl-methanofuran dehydrogenase (molybdenum enzyme) complex
formyl-methanofuran dehydrogenase (tungsten enzyme) complex
fumarate reductase complex +
gamma-secretase complex A protein complex that has aspartic-type endopeptidase activity and contains a presenilin catalytic subunit (either PSEN1 or PSEN2), an APH1 subunit (multiple genes and splice variants exist), nicastrin (NCT), and presenilin enhancer (aka PEN-2 or Psenen), as the core complex. Variants of the complex with different subunit compositions differ in localization and specific substrates. Additionally, variants of the complex exist that contain a additional regulatory subunit as well as the four core subunits; known regulatory subunits include gamma-secretase-activating protein (aka gSAP), TMP1 (aka TMED10), and CD147 antigen (aka basigin). Gamma-secretase cleaves type I transmembrane protein substrates, including the cell surface receptor Notch and the amyloid-beta precursor protein.
gamma-secretase-Delta1 complex
glutamate decarboxylase complex
glutamate-cysteine ligase complex
glutamate-tRNA ligase complex
glutamyl-tRNA(Gln) amidotransferase complex
glutathione synthase complex
glycine-gated chloride channel complex
glycine-tRNA ligase complex
guanylate cyclase complex, soluble
heterotrimeric G-protein complex
high-affinity iron permease complex
histamine-gated chloride channel complex
histone deacetylase complex +
hydroxyisourate hydrolase complex
inhibin-betaglycan-ActRII complex
interleukin-12-interleukin-12 receptor complex
interleukin4-interleukin-4 receptor complex
intramolecular phosphotransferase complex +
inward rectifying potassium channel
L-cysteine desulfurase complex +
low-density lipoprotein receptor complex
lysosomal multienzyme complex
magnesium chelatase complex
mannosyl-oligosaccharide 1,2-alpha-mannosidase complex
methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex
methylcrotonoyl-CoA carboxylase complex +
mitochondrial inner membrane peptidase complex
mitochondrial processing peptidase complex
molybdopterin synthase complex
NAD(P)H dehydrogenase complex (plastoquinone) +
nitrite reductase complex [NAD(P)H]
nonsense-mediated decay complex
ornithine carbamoyltransferase inhibitor complex
Ost-alpha/Ost-beta complex
phenylalanine-tRNA ligase complex
phosphoenolpyruvate-dependent sugar phosphotransferase complex
phosphopantothenoylcysteine decarboxylase complex
phosphopyruvate hydratase complex
phosphoribosylaminoimidazole carboxylase complex
plasma membrane fumarate reductase complex
plasma membrane proton-transporting ATP synthase complex +
plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) +
plasma membrane proton-transporting ATP synthase complex, coupling factor F(o) +
plasma membrane proton-transporting ATP synthase, catalytic core
plasma membrane proton-transporting ATP synthase, central stalk
plasma membrane proton-transporting ATP synthase, stator stalk
plasma membrane proton-transporting V-type ATPase complex +
plasma membrane proton-transporting V-type ATPase, V0 domain
plasma membrane proton-transporting V-type ATPase, V1 domain
plasma membrane respiratory chain complex I
plasma membrane respiratory chain complex II +
plasma membrane respiratory chain complex III
plasma membrane respiratory chain complex IV
plasma membrane signaling receptor complex +
plasma membrane succinate dehydrogenase complex +
plasma membrane-derived photosystem I
plasma membrane-derived thylakoid photosystem II
plasma membrane-derived thylakoid ribulose bisphosphate carboxylase complex
platelet-derived growth factor receptor-ligand complex
polyketide synthase complex +
potassium:proton exchanging ATPase complex
proteasome core complex +
protocadherin-alpha-protocadherin-gamma complex +
pyrophosphate-dependent phosphofructokinase complex +
pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex
pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex
RecQ family helicase-topoisomerase III complex
respiratory chain complex II +
ribulose bisphosphate carboxylase complex +
serine-tRNA ligase complex
sodium:potassium-exchanging ATPase complex
sucrase-isomaltase complex
sulfite reductase complex (NADPH)
sulfopyruvate decarboxylase complex
SUMO activating enzyme complex
TAT protein transport complex
telomerase holoenzyme complex +
transmembrane collagen trimer +
tricarboxylic acid cycle heteromeric enzyme complex +
tRNA-specific adenosine-34 deaminase complex
tRNA-splicing ligase complex
ubiquitin activating enzyme complex
UDP-N-acetylglucosamine transferase complex
viral terminase, large subunit
voltage-gated calcium channel complex +
voltage-gated potassium channel complex +
voltage-gated sodium channel complex
Wnt-Frizzled-LRP5/6 complex
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Synonyms |
Exact Synonyms: |
presenilin complex
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Narrow Synonyms: |
CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant)
;
PS1 complex
;
PS2 complex
;
gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant)
;
gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN)
;
gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN)
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Related Synonyms: |
gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN) |
Definition Sources: |
GOC:krc, PMID:15286082, PMID:15890777, PMID:17047368, PMID:22122073, PMID:25565961, PMID:28320827, PMID:32616437 |
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