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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:37659
Term: oleanolic acid
Definition: A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
Chemical ID: MESH:D009828
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1decreases expressionISOSirt1 (Mus musculus)6480464CTDOleanolic Acid results in decreased expression of SIRT1 mRNA; Oleanolic Acid results in decreased expression of SIRT1 proteinPMID:37028458
Sirt1multiple interactionsISOSirt1 (Mus musculus)6480464CTDGW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of SIRT1 protein]; SRT1720 inhibits the reaction [Oleanolic Acid results in decreased expression of SIRT1 protein]PMID:37028458
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