GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Map3k5 | decreases expression | EXP | | 6480464 | CTD | Acetaminophen results in decreased expression of MAP3K5 mRNA | PMID:33387578 | Map3k5 | decreases expression | ISO | MAP3K5 (Homo sapiens) | 6480464 | CTD | Acetaminophen results in decreased expression of MAP3K5 mRNA | PMID:21420995 PMID:29067470 | Map3k5 | increases activity | ISO | Map3k5 (Mus musculus) | 6480464 | CTD | Acetaminophen results in increased activity of MAP3K5 protein | PMID:18700144 | Map3k5 | increases response to substance | ISO | Map3k5 (Mus musculus) | 6480464 | CTD | MAP3K5 protein results in increased susceptibility to Acetaminophen | PMID:18700144 | Map3k5 | multiple interactions | ISO | MAP3K5 (Homo sapiens) | 6480464 | CTD | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of MAP3K5 mRNA | PMID:33819548 | Map3k5 | multiple interactions | ISO | Map3k5 (Mus musculus) | 6480464 | CTD | MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ACTG1 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of AK5 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARIH1 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARL4A mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARL5B mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ARRDC5 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ASTN2 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of BCL2L14 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of BTC mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CASKIN1 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CCDC81 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CCL7 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CD3E mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CDS2 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CHIL3 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CHIL4 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CHKA mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CLASP1 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of COL3A1 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of COPG1 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of CXCL5 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DLX4 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DNAH5 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DNAJB4 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DNAJB9 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DPP6 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of EEA1 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of FOS mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of FOSL2 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GAB2 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GNAL mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GZMM mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of H2BC18 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of IFIT3 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of JUN mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of KDM3A mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MAFF mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MCL1 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MX2 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of MYH3 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NAIP6 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NEDD9 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NIPAL2 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of NSMCE2 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of OBP2A mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of OR13P5 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of OR4B1C mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of OR8B1C mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PCDH11X mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PCDH7 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PDCL2 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PDE4B mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PRRX1 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of PVR mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of RNF207 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of RTP1 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SCT mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SLC25A2 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SLFN3 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SPZ1 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of STAT3 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of SYF2 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TMEM54 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TRP63 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TSC22D2 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of TWSG1 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of USP31 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of USP6NL mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of WDFY3 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ZDHHC6 mRNA]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of ZFAND2A mRNA]; MAP3K5 protein promotes the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK8 protein]; MAP3K5 protein promotes the reaction [Acetaminophen results in increased phosphorylation of and results in increased activity of MAPK9 protein] | PMID:18700144 | | ||||||||||||||||||||||
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