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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306565
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Acc ID: CHEBI:29681
Term: surfactin
Definition: Any mixture comprising isoforms of a bacterial cyclic lipopeptide antibiotic produced by various strains of Bacillus subtilis. The isoforms are cyclodepsipeptides containing at least seven amino acid residues. Among the most effective biosurfactants, surfactin can reduce the surface tension of water from 72 to 27 mN/m at a concentration as low as 0.005%.
Chemical ID: MESH:C009365
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k5increases phosphorylationISOMAP3K5 (Homo sapiens)6480464CTDsurfactin peptide results in increased phosphorylation of MAP3K5 proteinPMID:34850538
Map3k5multiple interactionsISOMAP3K5 (Homo sapiens)6480464CTD4-methylumbelliferone 8-carbaldehyde inhibits the reaction [surfactin peptide results in increased phosphorylation of MAP3K5 protein]; KIRA6 inhibits the reaction [surfactin peptide results in increased phosphorylation of MAP3K5 protein]PMID:34850538
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