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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305476
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mki67
Name: marker of proliferation Ki-67
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mki67decreases expressionISOMKI67 (Homo sapiens)6480464CTDBortezomib results in decreased expression of MKI67 proteinPMID:19372569
Mki67multiple interactionsISOMki67 (Mus musculus)6480464CTD[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]]PMID:30482226
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