Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303073
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Xbp1
Name: X-box binding protein 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xbp1multiple interactionsEXP 6480464CTD[Streptozocin co-treated with Dietary Fats] results in decreased expression of XBP1 mRNA alternative form; Bilirubin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of XBP1 mRNA alternative form]; moutan cortex inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of XBP1 protein alternative form]; Streptozocin results in increased expression of and results in increased secretion of XBP1 protein alternative formPMID:27664441 PMID:37054934
Xbp1multiple interactionsISOXbp1 (Mus musculus)6480464CTD[Dietary Fats co-treated with Streptozocin] results in increased splicing of XBP1 mRNA; NUS1 protein inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased splicing of XBP1 mRNA]PMID:33812996
Go Back to source page   Continue to Ontology report