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GENE - TERM ANNOTATION REPORT

RGD ID: 12366613
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: IARS1
Name: isoleucyl-tRNA synthetase 1
Acc ID: GO:0006428
Term: isoleucyl-tRNA aminoacylation
Definition: The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.
Definition Source(s): GOC:mcc, ISBN:0716730510
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IARS1involved_inIEAUniProtKB:P41252 or UniProtKB:Q8BU30 or ensembl:ENSMUSP00000132082 or ensembl:ENSP00000406448150520179Ensembl GO_REF:0000107
IARS1involved_inIEAInterPro:IPR002301150520179InterPro GO_REF:0000002
IARS1acts_upstream_of_or_withinISOIARS1 (Homo sapiens)9068941MGI PMID:8052601

PMID:8052601
IARS1involved_inIEAPANTHER:PTHR42780:SF1150520179TreeGrafter GO_REF:0000118
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