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GENE - TERM ANNOTATION REPORT

RGD ID: 12314402
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: DLL1
Name: delta like canonical Notch ligand 1
Acc ID: GO:0002315
Term: marginal zone B cell differentiation
Definition: The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).
Definition Source(s): GOC:jal, ISBN:0781735149
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DLL1involved_inISODll1 (Mus musculus)9068941UniProt MGI:3044313 PMID:15146182 MGI:3838059 PMID:19217325

MGI:3044313 MGI:3838059 PMID:15146182 PMID:19217325
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