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GENE - TERM ANNOTATION REPORT

RGD ID: 12130431
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: APOA4
Name: apolipoprotein A4
Acc ID: GO:0034362
Term: low-density lipoprotein particle
Definition: A lipoprotein particle, rich in cholesterol esters and low in triglycerides that is typically composed of APOB100 and APOE and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. LDL particles are formed from VLDL particles (via IDL) by the loss of triglyceride and gain of cholesterol ester. They transport endogenous cholesterol (and to some extent triglycerides) from peripheral tissues back to the liver.
Definition Source(s): GOC:BHF, GOC:expert_pt, GOC:mah, GOC:rl
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APOA4part_ofIBAMGI:88057 or PANTHER:PTN004504672 or Apoa1 (Rattus norvegicus) or Apoe (Rattus norvegicus) or UniProtKB:P02649150520179GO_Central GO_REF:0000033
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