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GENE - TERM ANNOTATION REPORT

RGD ID: 12078373
Species: Canis lupus familiaris
RGD Object: Gene
Symbol: F2R
Name: coagulation factor II thrombin receptor
Acc ID: PW:0002607
Term: protease mediated signaling via protease-activated receptor 1
Definition: Protease-activated receptor 1 (PAR1/F2R) is primarily a target of coagulation factor 2, thrombin, but other proteases can prompt or disarm it. PAR1 signaling plays many roles in the immune, cardiovascular and nervous system.
Definition Source(s): PMID:25986685
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2R ISOF2R (Homo sapiens)9068941RGD PMID:23809128 PMID:27126649 REF_RGD_ID:11352286 REF_RGD_ID:11352294
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