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GENE - TERM ANNOTATION REPORT

RGD ID: 11893384
Species: Pan paniscus
RGD Object: Gene
Symbol: TLR2
Name: toll like receptor 2
Acc ID: PW:0000814
Term: Toll-like receptor signaling pathway
Definition: Toll-like receptors represent a large and the better understood family of pattern recognition receptors that sense an array of exogenous structures, and recent evidence shows they can also recognize defective endogenous molecules. The intracellular signaling cascades they set in motion lead to the expression of inflammatory mediators.
Definition Source(s): GO:0002224, KEGG:04620, PMID:20303867, PMID:20303872, Reactome:R-HSA-168898
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TLR2 ISOTLR2 (Homo sapiens)9068941RGD PMID:21235323 REF_RGD_ID:5685014
TLR2 ISOTlr2 (Rattus norvegicus)9068941RGD PMID:16973131 PMID:18353287 REF_RGD_ID:1643119 REF_RGD_ID:5684896
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