GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | increases expression | EXP | | 6480464 | CTD | Azathioprine results in increased expression of TNF mRNA | PMID:24184165 | Tnf | increases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Azathioprine results in increased expression of TNF protein | PMID:19584951 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Azathioprine; Azathioprine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] | PMID:19362101 PMID:36416909 | |
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