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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11429
Species: Mus musculus
RGD Object: Gene
Symbol: Tnf
Name: tumor necrosis factor
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfincreases expressionISOTnf (Rattus norvegicus)15036816RGDethanol increases expression of Tnf protein in liver 
Tnfincreases expressionISOTnf (Rattus norvegicus)407424599RGDethanol increases expression of Tnf protein in blood serum 
Tnfincreases expression ISOTnf (Rattus norvegicus)407424596RGDethanol increases expression of tnf in liver 
Tnfincreases expression ISOTnf (Rattus norvegicus)407424600RGDethanol increases expression of Tnf in blood serum 
Tnfmultiple interactionsISOTnf (Rattus norvegicus)38508890RGDethanol inhibits the reaction [[lipopolysaccharide co-treated with rat serum] increases secretion of Tnf protein by Kupffer cells] 
Tnfdecreases secretionEXP 6480464CTDEthanol results in decreased secretion of TNF proteinPMID:20624996
Tnfincreases activityEXP 6480464CTDEthanol results in increased activity of TNF proteinPMID:21086752
Tnfincreases expressionEXP 6480464CTDEthanol results in increased expression of TNF mRNA; Ethanol results in increased expression of TNF proteinPMID:15920153 PMID:16317704 PMID:22173916 PMID:22996800 PMID:23500890 PMID:23832548 PMID:23994557 PMID:24146112 PMID:24223948 PMID:24300194 PMID:24892905 PMID:24946281 PMID:26769846 PMID:26858005 PMID:26970604 PMID:27545833 PMID:27837167 PMID:27984176 PMID:28935932 PMID:29476730 PMID:31711802 PMID:31954762 PMID:33161052 PMID:34192554 PMID:35143882 PMID:37271273 PMID:37939858
Tnfincreases secretionEXP 6480464CTDEthanol results in increased secretion of TNF proteinPMID:34405320 PMID:35526736 PMID:37271273
Tnfmultiple interactionsEXP 6480464CTD1,3,5,6-tetrahydroxyxanthone inhibits the reaction [Ethanol results in increased expression of TNF protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]; 5-aminoisoquinolinone inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; [Dietary Fats co-treated with Cholesterol, Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Ethanol] results in increased expression of TNF protein; [Ethanol co-treated with Carbon Tetrachloride co-treated with 4-O-methylhonokiol] results in increased expression of TNF mRNA; [Ethanol co-treated with Dietary Fats co-treated with 5-aminoisoquinolinone] results in decreased expression of TNF mRNA; [Ethanol co-treated with Dietary Fats co-treated with N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride] results in decreased expression of TNF mRNA; [Ethanol co-treated with Dietary Fats co-treated with olaparib] results in decreased expression of TNF mRNA; [Ethanol co-treated with Dietary Fats] results in increased expression of TNF protein; [Ethanol co-treated with High Fructose Corn Syrup co-treated with lard] results in increased expression of TNF protein; [Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein; [Ethanol co-treated with isopentyl alcohol co-treated with Acetaminophen] results in increased expression of TNF protein; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF protein; [Ethanol co-treated with Lipopolysaccharides] results in increased secretion of TNF protein; [Ethanol co-treated with Thioacetamide] results in increased expression of TNF mRNA; [ethylene dichloride co-treated with Ethanol] results in increased expression of TNF protein; [lard co-treated with Ethanol co-treated with High Fructose Corn Syrup] results in increased expression of TNF protein; [Palmitic Acid co-treated with Ethanol] results in increased expression of TNF mRNA; [Palmitic Acid co-treated with Ethanol] results in increased secretion of TNF protein; ADORA2B protein inhibits the reaction [Ethanol results in increased expression of and results in increased secretion of TNF protein]; ADORA2B protein inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; allyl sulfide inhibits the reaction [[ethylene dichloride co-treated with Ethanol] results in increased expression of TNF protein]; BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; BAY 60-6583 inhibits the reaction [Ethanol results in increased expression of TNF protein]; boldine inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]; Cannabidiol inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Cannabidiol inhibits the reaction [Ethanol results in increased expression of TNF protein]; chelerythrine inhibits the reaction [Ethanol results in increased expression of TNF protein]; Chlormethiazole inhibits the reaction [Ethanol results in increased expression of TNF protein]; CIRBP gene mutant form inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; CIRBP gene mutant form inhibits the reaction [Ethanol results in increased expression of TNF protein]; CNR1 gene mutant form affects the reaction [[Ethanol co-treated with Thioacetamide] results in increased expression of TNF mRNA]; cobaltiprotoporphyrin inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; cobaltiprotoporphyrin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; costunolide inhibits the reaction [Ethanol results in increased expression of TNF protein]; dehydrocostus lactone inhibits the reaction [Ethanol results in increased expression of TNF protein]; Dexmedetomidine inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased secretion of TNF protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Ethanol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Ethanol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Ethanol inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Ethanol inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Ethanol inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Ethanol promotes the reaction [Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]]; Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Ethanol results in increased expression of and results in increased secretion of TNF protein; Fructose promotes the reaction [Ethanol results in increased expression of TNF mRNA]; glutinol inhibits the reaction [Ethanol results in increased expression of TNF protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]]; m-trifluoromethyl-diphenyl diselenide inhibits the reaction [[Ethanol co-treated with High Fructose Corn Syrup co-treated with lard] results in increased expression of TNF protein]; m-trifluoromethyl-diphenyl diselenide inhibits the reaction [[lard co-treated with Ethanol co-treated with High Fructose Corn Syrup] results in increased expression of TNF protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Ethanol results in increased expression of and results in increased secretion of TNF protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; NFATC4 protein affects the reaction [Ethanol results in increased expression of TNF protein]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]]; olaparib inhibits the reaction [Ethanol results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]; PARP1 protein affects the reaction [Ethanol results in increased expression of TNF mRNA]; Pentoxifylline inhibits the reaction [Ethanol results in increased expression of TNF protein]; platycodin D inhibits the reaction [Ethanol results in increased expression of and results in increased secretion of TNF protein]; pterostilbene inhibits the reaction [Ethanol results in increased secretion of TNF protein]; PTPN1 protein promotes the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; PTPN1 protein promotes the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Resveratrol inhibits the reaction [Ethanol results in increased activity of TNF protein]; RIPK3 protein affects the reaction [Ethanol results in increased expression of TNF protein]; Rosiglitazone inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; rucaparib inhibits the reaction [Ethanol results in increased expression of TNF protein]; SESN2 protein promotes the reaction [pterostilbene inhibits the reaction [Ethanol results in increased secretion of TNF protein]]; sodium boranocarbonate inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]; TLR4 gene mutant form inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; TLR4 gene mutant form inhibits the reaction [Ethanol results in increased expression of TNF protein]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Ethanol results in increased activity of TNF protein]; Zinc Sulfate inhibits the reaction [Ethanol results in increased expression of TNF protein]PMID:15920153 PMID:16317704 PMID:16439473 PMID:19500611 PMID:20052772 PMID:21086752 PMID:21863215 PMID:22173916 PMID:22319556 PMID:23500890 PMID:23994557 PMID:24146112 PMID:24223948 PMID:24300194 PMID:24892905 PMID:24946281 PMID:25478868 PMID:25927324 PMID:26769846 PMID:26858005 PMID:26970604 PMID:27545833 PMID:27837167 PMID:27984176 PMID:28689299 PMID:28935932 PMID:29317476 PMID:29476730 PMID:31711802 PMID:31954762 PMID:32531310 PMID:34192554 PMID:34405320 PMID:35143882 PMID:35526736 PMID:35863473 PMID:37023972 PMID:37054933 PMID:37150348 PMID:37271273 PMID:37939858
Tnfaffects expressionISOTnf (Rattus norvegicus)6480464CTDEthanol affects the expression of TNF proteinPMID:22178775
Tnfdecreases expressionISOTnf (Rattus norvegicus)6480464CTDEthanol results in decreased expression of TNF proteinPMID:25637687
Tnfincreases expressionISOTNF (Homo sapiens)6480464CTDEthanol results in increased expression of TNF; Ethanol results in increased expression of TNF mRNAPMID:11344824 PMID:22484158 PMID:28964808 PMID:34474091
Tnfincreases expressionISOTnf (Rattus norvegicus)6480464CTDEthanol results in increased expression of TNF; Ethanol results in increased expression of TNF mRNA; Ethanol results in increased expression of TNF proteinPMID:15475485 PMID:17887948 PMID:18271918 PMID:19371623 PMID:20116195 PMID:20923693 PMID:21172400 PMID:22063920 PMID:22413959 PMID:22446813 PMID:22465177 PMID:22525864 PMID:23273579 PMID:23274713 PMID:23422878 PMID:24146112 PMID:24769256 PMID:24972622 PMID:25111957 PMID:25168850 PMID:25289771 PMID:25859307 PMID:26115886 PMID:26522475 PMID:27474069 PMID:27989594 PMID:28456544 PMID:28852734 PMID:28963034 PMID:29085585 PMID:29339218 PMID:29704510 PMID:30098312 PMID:33314588 PMID:33645892 PMID:34346143 PMID:34547370 PMID:35156864 PMID:35227807 PMID:36085217 PMID:36453646 PMID:37499997
Tnfincreases secretionISOTNF (Homo sapiens)6480464CTDEthanol results in increased secretion of TNF proteinPMID:22841563 PMID:28013186 PMID:34474091
Tnfincreases secretionISOTnf (Rattus norvegicus)6480464CTDEthanol results in increased secretion of TNF proteinPMID:17603938
Tnfmultiple interactionsISOTNF (Homo sapiens)6480464CTD[Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; acanthoic acid inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; acanthoic acid inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Ethanol promotes the reaction [FOXO3 protein results in increased expression of TNF mRNA]; Ethanol promotes the reaction [sodium arsenite results in increased secretion of TNF protein]; Ethanol results in increased expression of and results in increased secretion of TNF protein; isosakuranetin inhibits the reaction [Ethanol results in increased secretion of TNF protein]; lucidone inhibits the reaction [Ethanol results in increased expression of TNF]; poncirin inhibits the reaction [Ethanol results in increased secretion of TNF protein]; PRKAA1 protein promotes the reaction [acanthoic acid inhibits the reaction [Ethanol results in increased expression of TNF mRNA]]; pterostilbene inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; pterostilbene inhibits the reaction [Ethanol results in increased secretion of TNF protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Ethanol results in increased expression of and results in increased secretion of TNF protein]; RIPK3 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of TNF mRNA]]; TLR3 protein affects the reaction [Ethanol results in increased expression of and results in increased secretion of TNF protein]; Vitamin E inhibits the reaction [Ethanol results in increased secretion of TNF protein]PMID:22484158 PMID:22841563 PMID:26220687 PMID:26470730 PMID:28013186 PMID:28964808 PMID:33161052 PMID:34474091
Tnfmultiple interactionsISOTnf (Rattus norvegicus)6480464CTD1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of TNF protein]; 8-(4-methoxyphenyl)-4-oxo-4,6,7,8-tetrahydroimidazo(2,1-c)(1,2,4)triazine-3-carbohydrazide inhibits the reaction [Ethanol results in increased expression of TNF protein]; [2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] promotes the reaction [Ethanol results in increased expression of TNF mRNA]; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of TNF mRNA; [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] co-treated with zinc protoporphyrin] results in increased expression of TNF protein; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF mRNA; [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF protein; [Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results in increased expression of TNF protein; [Ethanol co-treated with Fish Oils] results in increased expression of TNF protein; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA; [Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF protein; [Zinc binds to Curcumin] inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [Ethanol results in increased expression of TNF protein]; ADIPOQ protein inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; allyl sulfide inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Arbutin inhibits the reaction [Ethanol results in increased expression of TNF protein]; Artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; beta-patchoulene analog inhibits the reaction [Ethanol results in increased expression of TNF protein]; Cannabinoids inhibits the reaction [Ethanol results in increased expression of TNF protein]; caraway oil inhibits the reaction [Ethanol results in increased expression of TNF]; carvacrol inhibits the reaction [Ethanol results in increased expression of TNF protein]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Carvedilol inhibits the reaction [Ethanol results in increased expression of TNF protein]; chebulagic acid inhibits the reaction [Ethanol results in increased expression of TNF protein]; Clofibrate inhibits the reaction [[Ethanol co-treated with Fish Oils] results in increased expression of TNF protein]; Colchicine inhibits the reaction [Ethanol results in increased expression of TNF protein]; crocin inhibits the reaction [Ethanol results in decreased expression of TNF protein]; Curcumin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of TNF protein]; dichlorido-zinc(II)-4-(2-(5-methoxybenzylideneamino)ethyl)piperazin-1-iumphenolate inhibits the reaction [Ethanol affects the expression of TNF protein]; dioscin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Drugs, Chinese Herbal inhibits the reaction [Ethanol results in increased expression of TNF protein]; Ethanol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ethanol promotes the reaction [[2,4-dichlorophenoxyacetic acid isooctyl ester results in increased abundance of 2,4-Dichlorophenoxyacetic Acid] which results in increased expression of TNF mRNA]; Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF mRNA]; Ethanol promotes the reaction [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] results in increased expression of TNF protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of TNF protein]; Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Famotidine inhibits the reaction [Ethanol results in increased expression of TNF protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of TNF protein]; Fomepizole inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; gamma-Aminobutyric Acid inhibits the reaction [Ethanol results in increased expression of TNF protein]; Genistein inhibits the reaction [Ethanol results in increased expression of TNF protein]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF mRNA]; Hemin inhibits the reaction [[[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Ethanol] results in increased expression of TNF protein]; homoorientin inhibits the reaction [Ethanol results in increased expression of TNF protein]; honokiol inhibits the reaction [Ethanol results in increased expression of TNF protein]; IL10 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]]; Lansoprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]; LEPR gene mutant form promotes the reaction [Ethanol results in increased expression of TNF mRNA]; lipostabil inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; myricetin inhibits the reaction [Ethanol results in increased expression of TNF protein]; nymphayol inhibits the reaction [Ethanol results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of TNF protein]; patchouli alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein]; perillyl alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein]; Pioglitazone inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF mRNA]; Pioglitazone inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Plant Extracts inhibits the reaction [Ethanol results in increased expression of TNF protein]; platycodin D inhibits the reaction [Ethanol results in increased expression of TNF protein]; Resveratrol inhibits the reaction [Ethanol results in increased expression of TNF]; salvianolic acid B inhibits the reaction [Ethanol results in increased expression of TNF protein]; Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Scopoletin inhibits the reaction [Ethanol results in increased expression of TNF protein]; Silymarin inhibits the reaction [Ethanol results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Ethanol results in increased expression of TNF protein]; STIM1 protein affects the reaction [Ethanol results in increased expression of TNF protein]; thymoquinone inhibits the reaction [Ethanol results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]PMID:10231168 PMID:15016835 PMID:15318101 PMID:15475485 PMID:17603938 PMID:17887948 PMID:19371623 PMID:20052772 PMID:20116195 PMID:20923693 PMID:22063920 PMID:22178775 PMID:22413959 PMID:22446813 PMID:22465177 PMID:22525864 PMID:23274713 PMID:23422878 PMID:24146112 PMID:24769256 PMID:24972622 PMID:25168850 PMID:25289771 PMID:25637687 PMID:25859307 PMID:26115886 PMID:26522475 PMID:26747958 PMID:27474069 PMID:27989594 PMID:28456544 PMID:28852734 PMID:28963034 PMID:29085585 PMID:29339218 PMID:29704510 PMID:30098312 PMID:33314588 PMID:33645892 PMID:34346143 PMID:35156864 PMID:35872049 PMID:36085217 PMID:36453646 PMID:37499997
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