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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11280
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl12
Name: C-X-C motif chemokine ligand 12
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl12affects response to substanceISOCXCL12 (Homo sapiens)6480464CTDCXCL12 mRNA affects the susceptibility to GenisteinPMID:22549810
Cxcl12increases expressionISOCXCL12 (Homo sapiens)6480464CTDGenistein results in increased expression of CXCL12 mRNA; Genistein results in increased expression of CXCL12 proteinPMID:22549810 PMID:26865669 PMID:28396216
Cxcl12increases secretionISOCXCL12 (Homo sapiens)6480464CTDGenistein results in increased secretion of CXCL12 proteinPMID:20549624
Cxcl12multiple interactionsISOCXCL12 (Homo sapiens)6480464CTDbisphenol A inhibits the reaction [Genistein results in increased expression of CXCL12 mRNA]; bisphenol A inhibits the reaction [Genistein results in increased expression of CXCL12 protein]; fulvestrant inhibits the reaction [Genistein results in increased expression of CXCL12 mRNA]; fulvestrant inhibits the reaction [Genistein results in increased expression of CXCL12 protein]PMID:22549810
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