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GENE - TERM ANNOTATION REPORT

RGD ID: 11018
Species: Mus musculus
RGD Object: Gene
Symbol: Nras
Name: neuroblastoma ras oncogene
Acc ID: DOID:0080798
Term: myeloid leukemia associated with Down Syndrome
Definition: An acute megakaryocytic leukemia occurring in children with Down syndrome and that has_material_basis_in mutation in the GATA1 gene. (DO)
Definition Source(s): https://pubmed.ncbi.nlm.nih.gov/26910243/ "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/31606922/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nras ISONRAS (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:24056718
Nras ISONRAS (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Acute megakaryoblastic leukemia in down syndromePMID:16291983 PMID:17332249 PMID:17517660 PMID:18375819 PMID:18390968 PMID:19657110 PMID:19775298 PMID:20130576 PMID:20179705 PMID:21079152 PMID:23414587 PMID:23431193 PMID:2407301 PMID:25157968 PMID:25741868 PMID:26619011 PMID:2674680 PMID:27993330 PMID:2989702 PMID:8120410
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