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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10998
Species: Mus musculus
RGD Object: Gene
Symbol: Notch1
Name: notch 1
Acc ID: CHEBI:2430
Term: aconitine
Definition: A diterpenoid that is 20-ethyl-3alpha,13,15alpha-trihydroxy-1alpha,6alpha,16beta-trimethoxy-4-(methoxymethyl)aconitane-8,14alpha-diol having acetate and benzoate groups at the 8- and 14-positions respectively.
Chemical ID: MESH:D000157
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Notch1affects expressionISONOTCH1 (Homo sapiens)6480464CTDAconitine affects the expression of NOTCH1 proteinPMID:32234357
Notch1increases expressionISONotch1 (Rattus norvegicus)6480464CTDAconitine results in increased expression of NOTCH1 protein; Aconitine results in increased expression of NOTCH1 protein modified formPMID:32234357
Notch1increases expressionISONOTCH1 (Homo sapiens)6480464CTDAconitine results in increased expression of NOTCH1 protein modified formPMID:32234357
Notch1multiple interactionsISONotch1 (Rattus norvegicus)6480464CTDAconitine affects the reaction [NOTCH1 protein modified form binds to HCN4 promoter]; crenigacestat inhibits the reaction [Aconitine results in increased expression of NOTCH1 protein modified form]PMID:32234357
Notch1multiple interactionsISONOTCH1 (Homo sapiens)6480464CTDAconitine promotes the reaction [NOTCH1 protein modified form binds to HCN4 promoter]; Aconitine promotes the reaction [NOTCH1 protein modified form binds to KDM5A protein]; crenigacestat affects the reaction [Aconitine affects the expression of NOTCH1 protein]; crenigacestat inhibits the reaction [Aconitine results in increased expression of NOTCH1 protein modified form]PMID:32234357
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