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GENE - TERM ANNOTATION REPORT

RGD ID: 10997
Species: Mus musculus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3, endothelial cell
Acc ID: DOID:9002165
Term: Diabetic Nephropathies
Definition: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.
Definition Source(s): MESH:D003928
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3no_associationISONOS3 (Homo sapiens)7421534RGDassociated with Diabetes Mellitus, Type 2;DNA:duplication:intron:IVS4?-?+27 (human) 
Nos3susceptibilityISONOS3 (Homo sapiens)7421530RGDassociated with Diabetes Mellitus, Type 2;DNA:duplication:intron:IVS4?-?+27 (human) 
Nos3treatmentISONos3 (Rattus norvegicus)13504726RGDassociated with Diabetes Mellitus, Experimental 
Nos3 ISONOS3 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:20042665
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