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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10997
Species: Mus musculus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3, endothelial cell
Acc ID: CHEBI:7549
Term: N(gamma)-nitro-L-arginine methyl ester
Definition: An alpha-amino acid ester that is the methyl ester of N(gamma)-nitro-L-arginine.
Chemical ID: MESH:D019331
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3decreases expressionISONos3 (Rattus norvegicus)6480464CTDNG-Nitroarginine Methyl Ester results in decreased expression of NOS3 proteinPMID:32479886
Nos3decreases expressionISONOS3 (Homo sapiens)6480464CTDNG-Nitroarginine Methyl Ester results in decreased expression of NOS3 proteinPMID:28624453
Nos3multiple interactionsISONos3 (Rattus norvegicus)6480464CTDSildenafil Citrate inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein]; tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein]PMID:32479886
Nos3multiple interactionsISONOS3 (Homo sapiens)6480464CTD[Folic Acid co-treated with NG-Nitroarginine Methyl Ester] results in decreased expression of NOS3 proteinPMID:28624453
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