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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10997
Species: Mus musculus
RGD Object: Gene
Symbol: Nos3
Name: nitric oxide synthase 3, endothelial cell
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos3decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of NOS3 mRNA; Dexamethasone results in decreased expression of NOS3 proteinPMID:15050533 PMID:30940551
Nos3increases response to substanceEXP 6480464CTDNOS3 gene mutant form results in increased susceptibility to DexamethasonePMID:18030227
Nos3multiple interactionsEXP 6480464CTD[Dexamethasone co-treated with Indomethacin] results in decreased expression of NOS3 protein; diisononyl phthalate promotes the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Enalapril inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in decreased expression of NOS3 protein]]PMID:18030227 PMID:30940551
Nos3decreases expressionISONos3 (Rattus norvegicus)6480464CTDDexamethasone results in decreased expression of NOS3 mRNA; Dexamethasone results in decreased expression of NOS3 proteinPMID:14618091 PMID:17042910 PMID:20068362
Nos3decreases expressionISONOS3 (Homo sapiens)6480464CTDDexamethasone results in decreased expression of NOS3 proteinPMID:23426970
Nos3increases expressionISONos3 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of NOS3 mRNAPMID:10484530
Nos3increases expressionISONOS3 (Homo sapiens)6480464CTDDexamethasone results in increased expression of NOS3 mRNAPMID:19853017
Nos3multiple interactionsISONos3 (Rattus norvegicus)6480464CTD[Dexamethasone co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; [Vitamin E co-treated with Ascorbic Acid] inhibits the reaction [Dexamethasone results in decreased expression of NOS3 protein]; Atorvastatin inhibits the reaction [Dexamethasone results in decreased expression of NOS3 mRNA]PMID:17042910 PMID:20068362
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