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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10996
Species: Mus musculus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2, inducible
Acc ID: CHEBI:50694
Term: minocycline
Definition: A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.
Chemical ID: MESH:D008911
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2multiple interactionsEXP 6480464CTDMinocycline inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]PMID:19285099 PMID:37394652
Nos2multiple interactionsISONos2 (Rattus norvegicus)6480464CTDMinocycline inhibits the reaction [lead acetate results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Minocycline inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Minocycline inhibits the reaction [manganese chloride results in increased expression of NOS2 protein]PMID:15485488 PMID:18836210 PMID:22952811
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