Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10916
Species: Mus musculus
RGD Object: Gene
Symbol: Mpo
Name: myeloperoxidase
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mpoincreases activityEXP 6480464CTDCarbon Tetrachloride results in increased activity of MPO proteinPMID:24717679 PMID:24973641
Mpomultiple interactionsEXP 6480464CTDMetformin inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; ruxolitinib inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]PMID:24717679 PMID:24973641
Mpodecreases expressionISOMpo (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in decreased expression of MPO mRNAPMID:31150632
Mpoincreases activityISOMpo (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased activity of MPO proteinPMID:14697411 PMID:16278809 PMID:16724977 PMID:24144775 PMID:26929000 PMID:30825423
Mpoincreases expressionISOMpo (Rattus norvegicus)6480464CTDCarbon Tetrachloride results in increased expression of MPO proteinPMID:15745444
Mpomultiple interactionsISOMpo (Rattus norvegicus)6480464CTD[Chondroitin Sulfates co-treated with Hyaluronic Acid] inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; Anthocyanins inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; IGF1 protein inhibits the reaction [Carbon Tetrachloride results in increased expression of MPO protein]; olmesartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]PMID:14697411 PMID:15745444 PMID:24144775 PMID:26929000 PMID:30825423
Go Back to source page   Continue to Ontology report