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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10811
Species: Mus musculus
RGD Object: Gene
Symbol: Ins1
Name: insulin I
Acc ID: CHEBI:9613
Term: tolazamide
Definition: An N-sulfonylurea that is 1-tosylurea in which a hydrogen attached to the nitrogen at position 3 is replaced by an azepan-1-yl group. A hypoglycemic agent, it is used for the treatment of type 2 diabetes mellitus.
Chemical ID: MESH:D014042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ins1increases response to substanceISOIns1 (Rattus norvegicus)6480464CTDTolazamide results in increased susceptibility to INS1 proteinPMID:6337899
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