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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10790
Species: Mus musculus
RGD Object: Gene
Symbol: Il1b
Name: interleukin 1 beta
Acc ID: CHEBI:28865
Term: taurocholic acid
Definition: A bile acid taurine conjugate of cholic acid that usually occurs as the sodium salt of bile in mammals.
Chemical ID: MESH:D013656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il1bincreases expressionEXP 6480464CTDTaurocholic Acid results in increased expression of IL1B mRNAPMID:21224055
Il1bmultiple interactionsEXP 6480464CTDEGR1 promotes the reaction [Taurocholic Acid results in increased expression of IL1B mRNA]PMID:21224055
Il1bdecreases importISOIL1B (Homo sapiens)6480464CTDIL1B protein results in decreased import of Taurocholic AcidPMID:30876886
Il1bincreases expressionISOIl1b (Rattus norvegicus)6480464CTDTaurocholic Acid results in increased expression of IL1B mRNA; Taurocholic Acid results in increased expression of IL1B proteinPMID:25604657
Il1bmultiple interactionsISOIl1b (Rattus norvegicus)6480464CTDastragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B protein]PMID:25604657
Il1bmultiple interactionsISOIL1B (Homo sapiens)6480464CTD[TNF protein co-treated with IL6 protein co-treated with IL1B protein] results in decreased import of Taurocholic AcidPMID:30876886
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