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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10596
Species: Mus musculus
RGD Object: Gene
Symbol: Fos
Name: FBJ osteosarcoma oncogene
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fosmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased expression of FOS protein]; Acetylcysteine inhibits the reaction [oxaliplatin results in increased expression of FOS protein]; Acetylcysteine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of FOS mRNA]PMID:10692565 PMID:15520183 PMID:16137721 PMID:19654923 PMID:24908156
Fosdecreases activityISOFOS (Homo sapiens)6480464CTDAcetylcysteine results in decreased activity of FOS proteinPMID:14623829
Fosmultiple interactionsISOFos (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in decreased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of and results in increased phosphorylation of FOS protein]; Acetylcysteine promotes the reaction [bis(maltolato)oxovanadium(IV) results in decreased activity of [FOS protein binds to JUN protein]]PMID:17696279 PMID:22129741 PMID:36813253 PMID:7743507 PMID:8825185
Fosmultiple interactionsISOFOS (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS]; Acetylcysteine inhibits the reaction [Etoposide results in increased expression of FOS]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased activity of FOS protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of FOS mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of FOS]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of FOS protein]; Acetylcysteine inhibits the reaction [xanthatin results in increased expression of FOS]PMID:14623829 PMID:20654705 PMID:23824011 PMID:8853906 PMID:9043100 PMID:9525474
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