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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:34445
Term: 4-tert-Octylphenol
Definition: An alkylbenzene that has formula C14H22O.
Chemical ID: MESH:C105260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2affects bindingISOESR2 (Homo sapiens)6480464CTD4-tert-octylphenol binds to ESR2 proteinPMID:10964929 PMID:12161000 PMID:12224631 PMID:19913605
Esr2increases expressionISOESR2 (Homo sapiens)6480464CTD4-tert-octylphenol results in increased expression of ESR2 mRNAPMID:12737316
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTD4-tert-octylphenol binds to and results in increased activity of ESR2 protein; 4-tert-octylphenol inhibits the reaction [Estradiol binds to ESR2 protein]; 4-tert-octylphenol promotes the reaction [ESR2 protein binds to NCOA1 protein]; 4-tert-octylphenol promotes the reaction [ESR2 protein binds to NCOA2 protein]PMID:10964929 PMID:27633901 PMID:33049310
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