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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:34445
Term: 4-tert-Octylphenol
Definition: An alkylbenzene that has formula C14H22O.
Chemical ID: MESH:C105260
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects bindingISORGD:692136480464CTD4-tert-octylphenol binds to ESR2 protein

PMID:10964929, PMID:12161000, PMID:12224631, PMID:19913605
increases expressionISORGD:692136480464CTD4-tert-octylphenol results in increased expression of ESR2 mRNA

PMID:12737316
multiple interactionsISORGD:692136480464CTD4-tert-octylphenol binds to and results in increased activity of ESR2 protein, 4-tert-octylphenol inhibits the reaction [Estradiol binds to ESR2 protein], 4-tert-octylphenol promotes the reaction [ESR2 protein binds to NCOA1 protein], 4-tert-octylphenol promotes the reaction [ESR2 protein binds to NCOA2 protein]

PMID:10964929, PMID:27633901
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.