GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr2 | affects binding | ISO | Esr2 (Rattus norvegicus) | 8694130 | RGD | Methoxychlor binds to Esr2 protein | | Esr2 | decreases expression | EXP | | 6480464 | CTD | Methoxychlor metabolite results in decreased expression of ESR2 mRNA | PMID:11509743 | Esr2 | increases expression | EXP | | 6480464 | CTD | Methoxychlor metabolite results in increased expression of ESR2 mRNA; Methoxychlor results in increased expression of ESR2 mRNA | PMID:11509743 PMID:21252393 | Esr2 | multiple interactions | EXP | | 6480464 | CTD | [Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of ESR2 mRNA; [Estradiol co-treated with Methoxychlor metabolite] results in increased expression of ESR2 mRNA; ESR1 protein inhibits the reaction [Methoxychlor results in increased expression of ESR2 mRNA] | PMID:11509743 PMID:21252393 | Esr2 | affects binding | ISO | ESR2 (Homo sapiens) | 6480464 | CTD | Methoxychlor binds to ESR2 protein | PMID:12224631 PMID:9751507 | Esr2 | affects methylation | ISO | Esr2 (Rattus norvegicus) | 6480464 | CTD | Methoxychlor affects the methylation of ESR2 gene | PMID:35440735 | Esr2 | decreases expression | ISO | Esr2 (Rattus norvegicus) | 6480464 | CTD | Methoxychlor results in decreased expression of ESR2 mRNA; Methoxychlor results in decreased expression of ESR2 protein | PMID:18848953 PMID:22285353 | Esr2 | increases activity | ISO | ESR2 (Homo sapiens) | 6480464 | CTD | Methoxychlor results in increased activity of ESR2 protein | PMID:26139245 | Esr2 | increases methylation | ISO | Esr2 (Rattus norvegicus) | 6480464 | CTD | Methoxychlor results in increased methylation of ESR2 promoter | PMID:19589859 | Esr2 | multiple interactions | ISO | Esr2 (Rattus norvegicus) | 6480464 | CTD | [Genistein co-treated with Methoxychlor] results in increased expression of ESR2 mRNA; [o,p'-DDT co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Methoxychlor co-treated with Endosulfan co-treated with DDT] results in increased activity of ESR2 protein; Methoxychlor inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Methoxychlor inhibits the reaction [FSHB protein results in increased expression of ESR2 mRNA]; Methoxychlor inhibits the reaction [FSHB protein results in increased expression of ESR2 protein]; Methoxychlor metabolite binds to and results in decreased activity of ESR2 protein | PMID:10579340 PMID:16443925 PMID:25549949 PMID:9492041 PMID:9860891 | Esr2 | multiple interactions | ISO | ESR2 (Homo sapiens) | 6480464 | CTD | [Methoxychlor affects the activity of ESR2 protein] promotes the reaction [LIF protein results in increased activity of STAT3 protein]; Methoxychlor analog binds to and results in decreased activity of ESR2 protein; Methoxychlor binds to and results in decreased activity of ESR2 protein; Methoxychlor inhibits the reaction [Estradiol binds to ESR2 protein]; Methoxychlor metabolite binds to and results in decreased activity of ESR2 protein; Methoxychlor metabolite inhibits the reaction [Genistein binds to and results in increased activity of ESR2 protein] | PMID:10579340 PMID:10999957 PMID:11861976 PMID:14975756 PMID:16626760 PMID:9751507 | | ||||||||||||||||||||||
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