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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10529
Species: Mus musculus
RGD Object: Gene
Symbol: Ephx1
Name: epoxide hydrolase 1, microsomal
Acc ID: CHEBI:44445
Term: nimesulide
Definition: An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chemical ID: MESH:C012655
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ephx1decreases glutathionylationISOEPHX1 (Homo sapiens)6480464CTDEPHX1 protein results in decreased glutathionylation of nimesulidePMID:26524229
Ephx1increases expressionISOEphx1 (Rattus norvegicus)6480464CTDnimesulide results in increased expression of EPHX1 mRNAPMID:24136188
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