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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10436
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:16664
Term: albendazole
Definition: A carbamate ester that is methyl 1H-benzimidazol-2-ylcarbamate substituted by a propylsulfanyl group at position 5. It is commonly used in the treatment of parasitic worm infestations.
Chemical ID: MESH:D015766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases activityEXP 6480464CTDAlbendazole results in increased activity of CYP1A1 proteinPMID:16714371
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDAlbendazole results in decreased activity of CYP1A1 proteinPMID:33814510
Cyp1a1increases activityISOCYP1A1 (Homo sapiens)6480464CTDAlbendazole results in increased activity of CYP1A1 promoter; Albendazole results in increased activity of CYP1A1 proteinPMID:12451431 PMID:16714371 PMID:18502397
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDAlbendazole results in increased expression of CYP1A1 mRNAPMID:12451431
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