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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10436
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:8768
Term: rabeprazole
Definition: A sulfoxide that has formula C18H21N3O3S.
Chemical ID: MESH:D064750
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1decreases activityISOCYP1A1 (Homo sapiens)6480464CTDRabeprazole results in decreased activity of CYP1A1 proteinPMID:33814510
Cyp1a1increases expressionISOCyp1a1 (Rattus norvegicus)6480464CTDRabeprazole results in increased expression of CYP1A1 mRNAPMID:25626140
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDRabeprazole results in increased expression of CYP1A1 mRNA; Rabeprazole results in increased expression of CYP1A1 proteinPMID:12623754 PMID:9041675
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