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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10425
Species: Mus musculus
RGD Object: Gene
Symbol: Cycs
Name: cytochrome c, somatic
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cycsmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of CYCS protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CYCS mRNA]; Acetylcysteine inhibits the reaction [Methylmercury Compounds affects the localization of CYCS protein]PMID:21549813 PMID:29248572 PMID:34547296
Cycsdecreases expressionISOCYCS (Homo sapiens)6480464CTDAcetylcysteine results in decreased expression of CYCS proteinPMID:35123993
Cycsmultiple interactionsISOCYCS (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [dimethoxycurcumin affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [hydroquinone results in increased expression of CYCS protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased expression of CYCS protein]; Acetylcysteine inhibits the reaction [Polystyrenes analog results in increased expression of CYCS protein]; Acetylcysteine inhibits the reaction [sodium arsenite affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [surfactin peptide affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [TNFSF10 protein affects the localization of CYCS protein]PMID:19536524 PMID:19954742 PMID:21221209 PMID:23711929 PMID:35123993 PMID:35396826 PMID:37084995
Cycsmultiple interactionsISOCycs (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [arsenic trioxide affects the localization of CYCS protein]; Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [CASP9 protein binds to CYCS protein]]; Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CYCS protein]; Acetylcysteine inhibits the reaction [nickel sulfate results in increased expression of CYCS mRNA]PMID:18483861 PMID:21145380 PMID:22085843 PMID:24634002 PMID:28296042
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