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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10230
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2
Name: B cell leukemia/lymphoma 2
Acc ID: CHEBI:41977
Term: daunorubicin
Definition: A natural product found in Actinomadura roseola.
Chemical ID: MESH:D003630
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2affects expressionISOBCL2 (Homo sapiens)6480464CTDDaunorubicin affects the expression of BCL2 mRNAPMID:27780733
Bcl2decreases expressionISOBcl2 (Rattus norvegicus)6480464CTDDaunorubicin results in decreased expression of BCL2 proteinPMID:37178933
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDDaunorubicin results in decreased expression of BCL2 mRNAPMID:19421372
Bcl2decreases response to substanceISOBCL2 (Homo sapiens)6480464CTDBCL2 results in decreased susceptibility to DaunorubicinPMID:21595920
Bcl2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTDTRPC6 protein promotes the reaction [Daunorubicin results in decreased expression of BCL2 protein]PMID:37178933
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Bortezomib co-treated with Daunorubicin] results in decreased expression of BCL2 mRNA; [bromotetrandrine co-treated with Daunorubicin] results in decreased expression of BCL2 protein; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BCL2 mRNA; [Daunorubicin co-treated with bromotetrandrine co-treated with Magnetite Nanoparticles] results in decreased expression of BCL2 protein; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BCL2 mRNA; [Daunorubicin co-treated with bromotetrandrine] results in decreased expression of BCL2 protein; [Daunorubicin co-treated with Magnetite Nanoparticles] results in decreased expression of BCL2 mRNA; [Magnetite Nanoparticles co-treated with Daunorubicin] promotes the reaction [bromotetrandrine results in decreased expression of BCL2 protein]; [Magnetite Nanoparticles co-treated with Daunorubicin] results in decreased expression of BCL2 protein; bromotetrandrine promotes the reaction [[Magnetite Nanoparticles co-treated with Daunorubicin] results in decreased expression of BCL2 protein]; bromotetrandrine promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]; bromotetrandrine promotes the reaction [Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]]; Magnetite Nanoparticles promotes the reaction [bromotetrandrine promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]]; Magnetite Nanoparticles promotes the reaction [Daunorubicin results in decreased expression of BCL2 mRNA]PMID:19421372 PMID:19918366 PMID:21302442 PMID:21720514
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