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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10230
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2
Name: B cell leukemia/lymphoma 2
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2decreases expressionEXP 6480464CTDcypermethrin results in decreased expression of BCL2 proteinPMID:38582279
Bcl2decreases expressionISOBcl2 (Rattus norvegicus)6480464CTDcypermethrin results in decreased expression of BCL2 mRNA; cypermethrin results in decreased expression of BCL2 proteinPMID:22048644 PMID:22528246 PMID:35876585
Bcl2decreases expressionISOBCL2 (Homo sapiens)6480464CTDcypermethrin results in decreased expression of BCL2 proteinPMID:38582279
Bcl2increases expressionISOBCL2 (Homo sapiens)6480464CTDcypermethrin results in increased expression of BCL2 mRNAPMID:27704156 PMID:32028016
Bcl2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTD[cypermethrin co-treated with decamethrin co-treated with fenvalerate co-treated with cyhalothrin co-treated with Allethrins] results in increased expression of BCL2 mRNA; [fenvalerate co-treated with Allethrins co-treated with cypermethrin co-treated with decamethrin co-treated with cyhalothrin] results in increased expression of BCL2 mRNA; HBEGF protein inhibits the reaction [cypermethrin results in decreased expression of BCL2 protein]; Quercetin inhibits the reaction [cypermethrin results in decreased expression of BCL2 mRNA]; Quercetin inhibits the reaction [cypermethrin results in decreased expression of BCL2 protein]PMID:22048644 PMID:33396045 PMID:34896426 PMID:35876585 PMID:36053783
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