GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | decreases expression | EXP | | 6480464 | CTD | Cyclophosphamide results in decreased expression of BCL2 mRNA; Cyclophosphamide results in decreased expression of BCL2 protein | PMID:29753871 PMID:30506662 PMID:33737021 | Bcl2 | multiple interactions | EXP | | 6480464 | CTD | Fungal Polysaccharides inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; ganoderic acid A inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein] | PMID:29753871 PMID:30506662 | Bcl2 | decreases expression | ISO | Bcl2 (Rattus norvegicus) | 6480464 | CTD | Cyclophosphamide results in decreased expression of BCL2 mRNA; Cyclophosphamide results in decreased expression of BCL2 protein | PMID:25446862 PMID:32197949 PMID:36154502 PMID:36198566 PMID:38211767 | Bcl2 | decreases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Cyclophosphamide results in decreased expression of BCL2 protein | PMID:34658283 | Bcl2 | increases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Cyclophosphamide results in increased expression of BCL2 mRNA | PMID:14503796 | Bcl2 | multiple interactions | ISO | Bcl2 (Rattus norvegicus) | 6480464 | CTD | [Rutin co-treated with Chitosan] inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 mRNA]; herbacetin inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 mRNA]; Melatonin inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; Plant Extracts inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 mRNA]; sacubitril and valsartan sodium hydrate drug combination inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein] | PMID:25446862 PMID:32197949 PMID:36154502 PMID:36198566 PMID:38211767 | Bcl2 | multiple interactions | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of BCL2 protein; [Doxorubicin co-treated with Cyclophosphamide] affects the expression of BCL2 mRNA; [Doxorubicin co-treated with Dexamethasone co-treated with Vincristine co-treated with Cytarabine co-treated with Mercaptopurine co-treated with Methotrexate co-treated with Cyclophosphamide co-treated with Enzymes and Coenzymes] results in increased expression of BCL2 protein; BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Cyclophosphamide results in increased activity of CASP9 protein]; Cyclophosphamide promotes the reaction [SGI-1027 results in decreased expression of BCL2 protein]; PAX5 protein affects the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; SGI-1027 promotes the reaction [Cyclophosphamide results in decreased expression of BCL2 protein]; Valproic Acid inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein] | PMID:11723234 PMID:15582267 PMID:16322899 PMID:21182165 PMID:34658283 | | ||||||||||||||||||||||
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