GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bcl2 | decreases expression | EXP | | 6480464 | CTD | Diethylhexyl Phthalate results in decreased expression of BCL2 mRNA; Diethylhexyl Phthalate results in decreased expression of BCL2 protein | PMID:26678702 PMID:31211961 PMID:35659966 PMID:35716406 PMID:36423848 PMID:37302538 PMID:38008054 | Bcl2 | increases expression | EXP | | 6480464 | CTD | Diethylhexyl Phthalate results in increased expression of BCL2 mRNA; Diethylhexyl Phthalate results in increased expression of BCL2 protein | PMID:25701202 PMID:33484791 PMID:36209858 | Bcl2 | multiple interactions | EXP | | 6480464 | CTD | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in decreased expression of BCL2 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with diethyl phthalate co-treated with diisononyl phthalate co-treated with di-n-octyl phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisodecyl phthalate] results in decreased expression of BCL2 protein; [diethyl phthalate co-treated with Dibutyl Phthalate co-treated with diisobutyl phthalate co-treated with Diethylhexyl Phthalate co-treated with butylbenzyl phthalate co-treated with diisononyl phthalate] results in increased expression of BCL2 mRNA; [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in increased expression of BCL2 mRNA; [Diethylhexyl Phthalate co-treated with Streptozocin co-treated with Dietary Fats] results in decreased expression of BCL2 protein; CSNK2B protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; MIR93 inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 mRNA]; NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 mRNA]]; RTKI cpd inhibits the reaction [NRG1 protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]] | PMID:28013214 PMID:33484791 PMID:35716406 PMID:35739755 PMID:37021957 PMID:37302538 PMID:37364641 PMID:38008054 | Bcl2 | decreases expression | ISO | Bcl2 (Rattus norvegicus) | 6480464 | CTD | Diethylhexyl Phthalate results in decreased expression of BCL2 mRNA; Diethylhexyl Phthalate results in decreased expression of BCL2 protein | PMID:32050098 PMID:38522500 | Bcl2 | decreases expression | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Diethylhexyl Phthalate results in decreased expression of BCL2 mRNA; Diethylhexyl Phthalate results in decreased expression of BCL2 protein | PMID:22155658 PMID:31163220 | Bcl2 | multiple interactions | ISO | Bcl2 (Rattus norvegicus) | 6480464 | CTD | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in increased expression of BCL2 mRNA; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein] | PMID:32050098 PMID:35762964 | Bcl2 | multiple interactions | ISO | BCL2 (Homo sapiens) | 6480464 | CTD | Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in decreased expression of BCL2 protein] | PMID:36394428 | | ||||||||||||||||||||||
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