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GENE - TERM ANNOTATION REPORT

2 Annotations Found.

An association has been curated linking Fgfr3 and cervix carcinoma in Chinchilla lanigera.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Automated assignment of GO, PW and RDO ISO annotations across species
  • The annotation has been inferred from sequence orthology with FGFR3 (Homo sapiens)
  • 39 RGD objects have been annotated to cervix carcinoma  (DOID:2893)
  • 2 papers in RGD have been used to annotate Fgfr3
  • Curation Notes: DNA:missense mutation:CDS:amino acid S249C, only found in 1/51 primary tumors and no cell lines tested implying that mutation frequency is much lower than previously reported
  • Original References(s): PMID:11114733 REF_RGD_ID:2289865


    • An association has been curated linking Fgfr3 and cervix carcinoma in Chinchilla lanigera.        

  • The association was inferred from sequence orthology (ISO)
    		•  
  • The annotation was made from Automated assignment of GO, PW and RDO ISO annotations across species
  • The annotation has been inferred from sequence orthology with FGFR3 (Homo sapiens)
  • 39 RGD objects have been annotated to cervix carcinoma  (DOID:2893)
  • 2 papers in RGD have been used to annotate Fgfr3
  • Curation Notes: DNA:missense mutations:CDS:somatic mutations found in 3/12 (25%) of cervix carcinomas, all mutations are equivalent to activating germline mutations which cause thanatophoric dysplasia
  • Original References(s): PMID:10471491 REF_RGD_ID:2289864


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