| Crl:CD(SD) |
urine total protein excretion rate |
control condition (for 28 days) then vehicle control condition (for 84 days) |
Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. |
total urine protein amount |
male |
112.0 days
| 5 |
|
36.7 |
mg/d |
3.5 |
7.83 |
urine protein analysis |
0.0 |
|
|
|
100768 |
2521 |
| Crl:CD(SD) |
retinal inner layer thickness |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
136.0 days-143.0 days |
5 |
|
123.8 |
um |
4.83 |
10.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105502 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer photoreceptor nucleus count |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
81.0 days-88.0 days |
5 |
|
11.3 |
null |
0.37 |
0.83 |
ex vivo light microscopy with histochemistry |
0.0 |
|
|
nuclei per cell |
105450 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
vehicle control condition (0 mg/kg) (for 13 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
67.0 days-74.0 days |
5 |
|
138.5 |
um |
3.4 |
7.6 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105474 |
3016 |
| Crl:CD(SD) |
urine protein level to urine creatinine level ratio |
control condition (for 28 days) then vehicle control condition (for 84 days) |
Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. |
total urine protein amount |
male |
112.0 days
| 5 |
|
1.98 |
null |
0.31 |
0.69 |
urine protein analysis |
0.0 |
|
|
|
100770 |
2521 |
| Crl:CD(SD) |
retinal outer layer thickness |
vehicle control condition (0 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
|
142.2 |
um |
2.68 |
6.0 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105466 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
vehicle control condition (0 mg/kg) (for 26 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
80.0 days-87.0 days |
10 |
|
136.0 |
um |
3.49 |
7.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105482 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
vehicle control condition (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
137.0 days-144.0 days |
5 |
|
50.6 |
um |
1.61 |
3.6 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
|
outer nuc layer |
105454 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
vehicle control condition (0 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
|
131.6 |
um |
4.87 |
10.9 |
optical coherence tomography |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105470 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
vehicle control condition (0 mg/kg) (for 13 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
67.0 days-74.0 days |
5 |
|
128.7 |
um |
4.92 |
11.0 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105478 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
111.0 days-118.0 days |
5 |
|
121.9 |
um |
4.38 |
9.8 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105494 |
3016 |
| Crl:CD(SD) |
blood urea nitrogen level |
control condition (for 28 days) then vehicle control condition (for 84 days) |
Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. |
blood urea nitrogen amount |
male |
112.0 days
| 5 |
|
19.3 |
mg/dl |
2.6 |
5.81 |
blood urea nitrogen analysis |
0.0 |
|
|
|
100764 |
2521 |
| Crl:CD(SD) |
full retina thickness |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
81.0 days-88.0 days |
5 |
|
177.2 |
um |
6.22 |
13.9 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
|
full retina layer |
105446 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
vehicle control condition (0 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
59.0 days-66.0 days |
5 |
|
41.0 |
um |
1.12 |
2.5 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
|
outer nuc layer |
105434 |
3016 |
| Crl:CD(SD) |
retinal outer nuclear layer photoreceptor nucleus count |
vehicle control condition (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
137.0 days-144.0 days |
5 |
|
10.5 |
null |
0.4 |
0.9 |
ex vivo light microscopy with histochemistry |
0.0 |
|
|
nuclei per cell |
105462 |
3016 |
| Crl:CD(SD) |
retinal inner layer thickness |
vehicle control condition (0 mg/kg) (for 26 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
80.0 days-87.0 days |
10 |
|
126.0 |
um |
4.02 |
9.0 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
inner retinal layer |
105486 |
3016 |
| Crl:CD(SD) |
serum estradiol level |
maternal milk (for 20 days) and vehicle control condition (for 15 days) |
Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. |
blood estradiol amount |
female |
50.0 days
| 32 |
|
34.4 |
pg/ml |
2.7 |
15.27 |
radioimmunoassay |
0.0 |
|
|
|
76260 |
1558 |
| Crl:CD(SD) |
post-insult time to mammary tumor formation |
maternal milk (for 20 days) and vehicle control condition (for 15 days) then 7,12-dimethyltetraphene (30 mg/kg) (for 1 days) |
Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. |
mammary gland integrity trait |
female |
days-365.0 days |
32 |
median |
65.0 |
d |
|
|
manual palpation method |
0.0 |
|
|
|
76267 |
1558 |
| Crl:CD(SD) |
serum progesterone level |
maternal milk (for 20 days) and vehicle control condition (for 15 days) |
Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. |
blood progesterone amount |
female |
50.0 days
| 32 |
|
12.5 |
ng/ml |
2.8 |
15.84 |
radioimmunoassay |
0.0 |
|
|
|
76262 |
1558 |
| Crl:CD(SD) |
serum creatinine level |
control condition (for 28 days) then vehicle control condition (for 84 days) |
Jia G, et al., Pediatr Nephrol. 2010 Jun;25(6):1139-46. Epub 2010 Mar 13. |
blood creatinine amount |
male |
112.0 days
| 5 |
|
0.43 |
mg/dl |
0.03 |
0.07 |
serum creatinine analysis |
0.0 |
|
|
|
100766 |
2521 |
| Crl:CD(SD) |
retinal outer nuclear layer thickness |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal outer nuclear layer morphology trait |
male |
81.0 days-88.0 days |
5 |
|
53.4 |
um |
2.33 |
5.2 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
|
outer nuc layer |
105442 |
3016 |
| Crl:CD(SD) |
retinal outer layer thickness |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
136.0 days-143.0 days |
5 |
|
129.8 |
um |
4.02 |
9.0 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105498 |
3016 |
| Crl:CD(SD) |
full retina thickness |
vehicle control condition (0 mg/kg) (for 5 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
59.0 days-66.0 days |
5 |
|
129.7 |
um |
3.71 |
8.3 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
|
full retina layer |
105438 |
3016 |
| Crl:CD(SD) |
full retina thickness |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
137.0 days-144.0 days |
5 |
|
191.6 |
um |
7.56 |
16.9 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
|
full retina layer |
105458 |
3016 |
| Crl:CD(SD) |
mammary tumor number |
maternal milk (for 20 days) and vehicle control condition (for 15 days) then 7,12-dimethyltetraphene (30 mg/kg) (for 1 days) |
Jenkins S, et al., Environ Health Perspect. 2009 Jun;117(6):910-5. doi: 10.1289/ehp.11751. Epub 2009 Jan 7. |
mammary gland integrity trait |
female |
days-365.0 days |
32 |
|
2.84 |
null |
0.31 |
1.75 |
manual palpation method |
0.0 |
|
|
|
76264 |
1558 |
| Crl:CD(SD) |
retinal outer layer thickness |
vehicle control condition (0 mg/kg) (for 25 days) |
Fielden MR, et al., Toxicol Pathol. 2015 Jun;43(4):581-92. doi: 10.1177/0192623314553804. Epub 2014 Oct 31. |
retinal layer morphology trait |
male |
111.0 days-118.0 days |
5 |
|
132.2 |
um |
3.71 |
8.3 |
ex vivo light microscopy with histochemistry and digital image analysis |
0.0 |
|
optical coherence tomography |
outer retinal layer |
105490 |
3016 |