Phenominer Database Results (905 results)

 
 
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Strain Phenotype Conditions Study Experiment Name Sex Age # of Animals Formula Value Units SEM SD Method Method Site Method Duration Post Insult Type Post Insult Time Value Post Insult Time Unit Method Notes Clinical Measurement Notes Sample Notes Experiment Notes Record ID Study ID
WKY/NCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 35.78 ml/min 3.26 10.8 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15487 381
WKY/NCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 12 18.16 mmHg 2.76 9.57 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15508 381
WKY/NCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 19.74 mmHg 3.66 9.69 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15516 381
WKY/NCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 12 -0.01 null 0.01 0.02 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15598 381
WKY/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 23.63 mmHg 0.72 2.04 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14390 381
WKY/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 3 21.6 mmHg 0.5 0.87 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14395 381
WKY/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 %change=VE during 2-3 min hypercapnia/control during standard conditions 249.68 % 14.56 50.45 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14405 381
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 23.85 mmHg 2.65 6.49 vascular fluid filled catheter 51766 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 25.49 mmHg 4.78 12.64 vascular fluid filled catheter 51763 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 21.82 mmHg 4.54 12.02 vascular fluid filled catheter 51784 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 22.37 mmHg 3.79 9.28 vascular fluid filled catheter 51787 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -101.53 beats/min 14.79 44.38 vascular fluid filled catheter 51937 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -46.2 beats/min 14.43 38.19 vascular fluid filled catheter 51940 481
WKY/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 6 6.9 ng/ml/h 2.37 5.82 radioimmunoassay 51960 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 -4.08 mmHg 3.15 9.46 vascular fluid filled catheter 52023 481
WKY/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 348.29 beats/min 5.0 15.01 vascular fluid filled catheter 52031 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 -0.9 mmHg 3.53 9.35 vascular fluid filled catheter 52026 481
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 118.22 mmHg 2.65 7.94 vascular fluid filled catheter 50546 481
WKY/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 6 1.14 ml/min 0.14 0.34 urine creatinine analysis 50575 481
WKY/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 9 0.32 mg/dl 0.01 0.04 radioimmunoassay 50690 481
WKY/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 371.77 beats/min 15.21 40.24 vascular fluid filled catheter 50708 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 2.9 mmHg 2.1 5.56 vascular fluid filled catheter 50771 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 -1.66 mmHg 4.53 11.99 vascular fluid filled catheter 51397 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 -1.31 mmHg 3.14 9.41 vascular fluid filled catheter 51622 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 15.74 mmHg 4.16 11.0 vascular fluid filled catheter 50405 481
WKY/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount male 87.0 days-120.0 days 9 0.4 mg/dl 0.02 0.06 radioimmunoassay 50409 481
WKY/NCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount female 87.0 days-120.0 days 8 16.23 mg/d 3.74 10.59 automated urine analysis 50443 481
WKY/NCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount female 87.0 days-120.0 days 8 3.61 mg/d 2.22 6.27 automated urine analysis 50469 481
WKY/NCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 5 29.5 mmHg 5.62 12.58 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14284 381
WKY/NCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 7 111.34 mmHg 2.47 6.55 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14299 381
WKY/NCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 3 110.98 mmHg 2.11 3.66 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13822 381
WKY/NCrl absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 -0.59 degrees C 0.26 0.87 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13864 381
WKY/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 14 110.54 mmHg 7.28 27.25 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13875 381
WKY/NCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 12 7.48 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14042 381
WKY/NCrl partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 11 103.08 mmHg 3.15 10.45 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14074 381
WKY/NCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 7.46 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20847 381
WKY/NCrl body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 16 37.38 degrees C 0.13 0.5 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19940 381
WKY/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 20 159.61 breaths/min 5.75 25.73 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17563 381
WKY/NCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 5 132.45 mmHg 5.38 12.04 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17597 381
WKY/NCrl body temperature control condition PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 37.15 degrees C 0.09 0.28 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17779 381
WKY/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 11 54.84 mmHg 1.5 4.99 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17005 381
WKY/NCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 6 117.99 mmHg 6.28 15.39 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18770 381
WKY/NCrl mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 12 103.44 mmHg 3.12 10.81 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18773 381
WKY/NCrl body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 37.33 degrees C 0.19 0.67 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18799 381
WKY/NCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 8 59.41 fl 0.65 1.83 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36285 401
WKY/NCrl blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 13 0.71 x 1000 cells/ul 0.1 0.36 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36304 401
WKY/NCrl serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 10 5.35 g/dl 0.07 0.22 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37412 401
WKY/NCrl red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 10 8.35 x 10E6 cells/ul 0.14 0.46 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36570 401
WKY/NCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 10 9.86 mg/dl 0.54 1.7 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36715 401
WKY/NCrl serum phosphate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 9 8.4 mg/dl 0.3 0.9 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36722 401
WKY/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 20 %change=VE during 2-3 min hypoxia/control during standard conditions 140.34 % 6.19 27.68 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19307 381
WKY/NCrl blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 11 7.49 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19316 381
WKY/NCrl respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 126.16 breaths/min 5.3 18.35 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18162 381
WKY/NCrl respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 187.49 breaths/min 1.88 6.22 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20174 381
WKY/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 15 -0.54 degrees C 0.21 0.82 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19153 381
WKY/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 9 19.49 % 9.73 29.2 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49028 461
WKY/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 10 19.08 % 8.84 27.96 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49036 461
WKY/NCrl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 7.64 g/kg 0.25 0.77 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49150 461
WKY/NCrl time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 835.13 s 66.98 211.81 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49487 461
WKY/NCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 69.93 % 6.45 20.4 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49659 461
WKY/NCrl heart weight to body weight ratio control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 5.8 g/kg 0.2 0.62 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49672 461
WKY/NCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 97.74 mmHg 5.33 16.85 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49788 461
WKY/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait female 49.0 days-63.0 days 10 9.71 % 3.01 9.53 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49862 461
WKY/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 131.0 g 6.8 21.4 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50086 461
WKY/NCrl absolute change in body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 20 -0.35 degrees C 0.24 1.05 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19161 381
WKY/NCrl hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 10 44.39 % 0.64 2.03 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38862 401
WKY/NCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 10 361.9 U/l 27.6 87.29 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42346 401
WKY/NCrl serum alkaline phosphatase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 9 247.22 U/l 18.74 56.23 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42353 401
WKY/NCrl plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 14 19.14 mmol/l 0.59 2.21 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42363 401
WKY/NCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity female 77.0 days-91.0 days 9 0.84 x 1000 cells/ul 0.09 0.27 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42373 401
WKY/NCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 32.3 g/dl 0.15 0.44 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42736 401
WKY/NCrl blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 13 14.33 g/dl 0.11 0.39 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42746 401
WKY/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 16 121.54 % 3.52 14.1 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54528 381
WKY/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 116.89 % 3.73 14.91 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53615 381
WKY/NCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 9 0.02 x 1000 cells/ul 0.01 0.04 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40508 401
WKY/NCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 9 0.23 x 1000 cells/ul 0.03 0.08 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40696 401
WKY/NCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 10 20.7 mmol/l 1.73 5.48 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37551 401
WKY/NCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 9 0.29 mg/dl 0.03 0.08 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37548 401
WKY/NCrl plasma anion gap controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data ion homeostasis trait female 77.0 days-91.0 days 9 19.0 mmol/l 0.29 0.87 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37558 401
WKY/NCrl blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 10 3.31 x 1000 cells/ul 0.23 0.72 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37936 401
WKY/NCrl blood lymphocyte count control condition (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 13 2.84 x 1000 cells/ul 0.23 0.82 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37943 401
WKY/NCrl mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 10 17.08 pg 0.05 0.17 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41272 401
WKY/NCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity male 77.0 days-91.0 days 8 2.61 x 1000 cells/ul 0.53 1.5 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38214 401
WKY/NCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 9 138.0 mmol/l 0.58 1.73 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38243 401
WKY/NCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 10 64.5 U/l 3.54 11.21 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41598 401
WKY/NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 0.04 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57432 522
WKY/NCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 10 1.46 g/kg 0.06 0.19 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57573 526
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 66.13 % 6.37 18.0 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55389 522
WKY/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 13 0.06 mmHg-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57698 526
WKY/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 9 1.5 mg/kg 0.36 1.08 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57770 526
WKY/NCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 0.55 E-7mole 0.13 0.44 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55978 522
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 -7.4 null 0.12 0.4 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54743 522
WKY/NCrl body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 15 256.8 g 4.6 17.7 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56068 522
WKY/NCrl body weight controlled sodium content diet (4 %) (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 10 168.0 g 3.7 11.8 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56075 522
WKY/NCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 12.06 ml/min/kg 1.4 4.42 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58841 526
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 19.69 % 2.95 10.65 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54997 522
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 -8.34 null 0.07 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55118 522
WKY/NCrl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 8.73 ml/min/kg 0.78 2.34 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59860 526
WKY/NCrl methylene blue metabolism-surface area product after auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 7.96 ml/min/kg 0.54 1.72 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59867 526
WKY/NCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 9 -7.4 null 0.05 0.16 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56741 522
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 15 62.53 % 4.49 17.39 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56747 522
WKY/NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 0.22 10E-7mol/l 0.07 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56762 522
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 29.0 % 2.97 10.69 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56825 522
WKY/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 7 1.12 mg/kg 0.28 0.74 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60106 526
WKY/NCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 37.84 ml/min/kg 4.55 13.66 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60128 526
WKY/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 20 0.25 ml 0.01 0.05 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16039 381
WKY/NCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 70.91 % 6.22 19.67 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45860 461
WKY/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 10.43 ml/min/g 2.93 9.25 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45889 461
WKY/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 7.68 ml/min/g 0.54 1.72 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45897 461
WKY/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 43.27 mmHg 5.71 16.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45931 461
WKY/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 53.59 % 3.91 11.74 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47882 461
WKY/NCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 6 145.24 mmHg 4.62 11.32 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46039 461
WKY/NCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 8 938.39 s 74.29 210.13 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48126 461
WKY/NCrl time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 1140.26 s 68.91 206.73 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45064 461
WKY/NCrl heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 10 43.6 mmHg 4.71 14.9 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47387 461
WKY/NCrl systolic blood pressure controlled exposure to ambient light (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 112.0 days 7 125.9 mmHg 0.49 1.3 vascular indwelling catheter method left common carotid artery 0.0 daytime (7 AM - 7 PM) 70081 1281
WKY/NCrl systolic blood pressure controlled exposure to darkness (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 112.0 days 7 130.0 mmHg 0.57 1.5 vascular indwelling catheter method left common carotid artery 0.0 nighttime (7 PM - 7 AM) 70082 1281
WKY/NCrl body weight control condition Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. body mass male 140.0 days 6 437.0 g 3.0 7.35 body weighing method 0.0 103487 2827
WKY/NCrl water intake drink rate to body weight ratio vehicle control condition (between 1 and 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. drinking behavior trait male 140.0 days-175.0 days 6 50.0 ml/d/kg 1.0 2.45 drink intake measuring method 103498 2827
WKY/NCrl water intake drink rate to body weight ratio salidroside (40 mg/kg) (between 1 and 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. drinking behavior trait male 140.0 days-175.0 days 6 50.0 ml/d/kg 1.0 2.45 drink intake measuring method 103499 2827
WKY/NCrl blood glucose level fasting (for 16 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 134.0 days 6 100.0 mg/dl 3.0 7.35 blood glucose test strip read by electrochemical glucometer 0.0 103506 2827
WKY/NCrl blood glucose level fasting (for 16 hours) then glucose (2 g/kg) (for 2 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 134.0 days 6 124.0 mg/dl 3.0 7.35 oral glucose tolerance test 0.0 103514 2827
WKY/NCrl kidney wet weight to body weight ratio control condition Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. kidney mass male 84.0 days 10 6.32 mg/g 0.11 0.35 post excision weight measurement 0.0 109275 3141
WKY/NCrl absolute change in heart rate artificial cerebrospinal fluid (200 nl) then angiotensin II (90 ng) then candesartan (0.05 ug) (for 0.2 hours) then angiotensin II (90 ng) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. heart pumping trait not specified  days 3 31.0 beats/min 11.0 19.05 vascular fluid filled catheter 0.0 110136 2685
WKY/NCrl body length, nose to tail controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length male 91.0 days 15 40.77 cm 0.13 0.52 body length measuring method tape measure Nose:tail body length Changed sex from M to male to standardize across records, 7-30-2024 140074 3292
WKY/NCrl body length, nose to rump controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length male 91.0 days 15 22.58 cm 0.07 0.27 body length measuring method tape measure Nose:Rump body length Changed sex from M to male to standardize across records, 7-30-2024 140073 3292
WKY/NCrl body weight control condition (0 null) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 7.0 days 15 10.62 g 0.32 1.22 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140076 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 91.0 days 15 297.87 g 3.72 14.43 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140088 3292
WKY/NCrl total body fat mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 21.0 days 15 12.19 % 0.5 1.93 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 140093 3292
WKY/NCrl total body lean mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 15 67.13 % 0.6 2.34 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 140094 3292
WKY/NCrl total body lean mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 15 43.36 g 1.69 6.54 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 140098 3292
WKY/NCrl total body water mass controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 70.0 days 15 17.89 g 0.26 1.01 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 140107 3292
WKY/NCrl defecation rate by mass controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait male 28.0 days 15 1.91 g/d 0.08 0.3 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from M to male to standardize across records, 7-30-2024 140115 3292
WKY/NCrl total body lean mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 15 65.91 % 0.4 1.53 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 140110 3292
WKY/NCrl average daily food intake weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait male 28.0 days 15 11.7 g/d 0.47 1.83 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from M to male to standardize across records, 7-30-2024 140113 3292
WKY/NCrl total body water mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 70.0 days 15 7.25 % 0.04 0.16 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 140111 3292
WKY/NCrl calculated water drink intake volume controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait male 70.0 days 15 28.4 mL/d 1.11 4.29 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from M to male to standardize across records, 7-30-2024 140118 3292
WKY/NCrl both adrenal glands wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. adrenal gland mass male 91.0 days 14 51.6 mg 0.93 3.49 post excision weight measurement weight scale Adrenal glands Changed sex from M to male to standardize across records, 7-30-2024 140132 3292
WKY/NCrl both testes wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. testis mass male 91.0 days 15 2.58 g 0.02 0.08 post excision weight measurement weight scale Testes Changed sex from M to male to standardize across records, 7-30-2024 140131 3292
WKY/NCrl thyroid gland wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. thyroid gland mass male 91.0 days 12 11.69 mg 0.49 1.7 post excision weight measurement weight scale Thyroid gland Changed sex from M to male to standardize across records, 7-30-2024 140133 3292
WKY/NCrl thymus wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. thymus mass male 91.0 days 6 246.32 mg 9.47 23.19 post excision weight measurement weight scale Thymus gland Changed sex from M to male to standardize across records, 7-30-2024 140135 3292
WKY/NCrl body length, nose to tail controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length male 91.0 days 15 40.7 cm 0.19 0.74 body length measuring method tape measure Nose:tail body length Changed sex from M to male to standardize across records, 7-30-2024 140137 3292
WKY/NCrl systolic blood pressure control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133.0 days-140.0 days 6 115.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry measured 12 hr/day for 1 week daytime measurement 103523 2827
WKY/NCrl diastolic blood pressure salidroside (40 mg/kg) (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168.0 days 6 87.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry measured 12 hr/night for 4 weeks nighttime measurement 103551 2827
WKY/NCrl heart rate control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 130.0 days-140.0 days 6 290.0 beats/min 4.0 9.8 intra-aortic abdominal radiotelemetry 0.0 measured 12 hr/day for 1 week daytime measurement 103554 2827
WKY/NCrl heart rate control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 133.0 days-140.0 days 6 347.0 beats/min 6.0 14.7 intra-aortic abdominal radiotelemetry 0.0 measured 12 hr/night for 1 week nighttime measurement 103562 2827
WKY/NCrl heart rate control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 133.0 days-140.0 days 6 337.0 beats/min 3.0 7.35 intra-aortic abdominal radiotelemetry 0.0 measured 12 hr/night for 1 week nighttime measurement 103563 2827
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 90.64 % 2.0 5.29 wire myography 0.0 103591 2827
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 -8.04 null 0.04 0.12 wire myography 0.0 103595 2827
WKY/NCrl aorta wall phosphorylated eNOS level to total eNOS level ratio vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. artery molecular composition trait male 175.0 days 7 1.45 null 0.21 0.56 western blot assay 0.0 103618 2827
WKY/NCrl body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 21.0 days 10 40.3 g 1.55 4.9 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139883 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 42 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 63.0 days 10 159.5 g 2.14 6.75 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139889 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 35 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 56.0 days 10 145.8 g 2.24 7.07 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139888 3292
WKY/NCrl total body lean mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 26.14 g 0.8 2.54 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 139895 3292
WKY/NCrl total body fat mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 21.0 days 10 13.95 % 0.47 1.48 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 139898 3292
WKY/NCrl total body lean mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 64.91 % 0.73 2.31 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 139899 3292
WKY/NCrl calories absorbed to calorie intake ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait female 70.0 days 10 87.89 % 0.71 2.24 constant volume calorimetry Bomb calorimetry; 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food Digestive efficiency Changed sex from F to female to standardize across records, 7-30-2024 139926 3292
WKY/NCrl epididymal fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. epididymal fat pad mass female 91.0 days 10 2.29 g 0.08 0.25 post excision weight measurement weight scale GWAT Changed sex from F to female to standardize across records, 7-30-2024 139932 3292
WKY/NCrl interscapular fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. interscapular fat pad mass female 91.0 days 10 268.21 mg 10.16 32.13 post excision weight measurement weight scale BAT Changed sex from F to female to standardize across records, 7-30-2024 139935 3292
WKY/NCrl both adrenal glands wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. adrenal gland mass female 91.0 days 10 61.19 mg 2.35 7.45 post excision weight measurement weight scale Adrenal glands Changed sex from F to female to standardize across records, 7-30-2024 139937 3292
WKY/NCrl serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount female 91.0 days 9 3.97 ng/dL 0.16 0.49 radioimmunoassay RIA; RRID:AB_2940788 Serum total T4 Changed sex from F to female to standardize across records, 7-30-2024 139943 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 28 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 49.0 days 10 130.7 g 2.39 7.54 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139953 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 14 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 35.0 days 10 85.3 g 2.38 7.53 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139951 3292
WKY/NCrl body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 21.0 days 10 39.8 g 1.43 4.52 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139949 3292
WKY/NCrl total body fat mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 21.0 days 10 5.62 g 0.39 1.24 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 139960 3292
WKY/NCrl timed urine mass controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. urination behavior trait female 70.0 days 10 16.75 g/d 1.89 5.99 metabolic cage urine mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour urine output Changed sex from F to female to standardize across records, 7-30-2024 139990 3292
WKY/NCrl blood glucose level controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) then fasting (for 16 hours) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood glucose amount female 91.0 days 10 73.0 mg/dl 2.44 7.7 blood glucose test strip read by electrochemical glucometer "overnight fast, saphenous vien "; "animals were fasted overnight (~16 hours), hind left leg shaved, pricked saphenous vein using a lancet, used glucometer to measure blood glucose" Fasted blood glucose Changed sex from F to female to standardize across records, 7-30-2024 139994 3292
WKY/NCrl liver wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. liver mass female 91.0 days 10 6.89 g 0.12 0.37 post excision weight measurement weight scale Liver Changed sex from F to female to standardize across records, 7-30-2024 139995 3292
WKY/NCrl calculated water drink intake volume controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait female 70.0 days 10 29.5 mL/d 2.33 7.37 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from F to female to standardize across records, 7-30-2024 139989 3292
WKY/NCrl interscapular fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. interscapular fat pad mass female 91.0 days 10 280.99 mg 16.11 50.93 post excision weight measurement weight scale BAT Changed sex from F to female to standardize across records, 7-30-2024 140001 3292
WKY/NCrl body length, nose to rump controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length female 91.0 days 10 20.39 cm 0.1 0.33 body length measuring method tape measure Nose:Rump body length Changed sex from F to female to standardize across records, 7-30-2024 140007 3292
WKY/NCrl thymus wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. thymus mass female 91.0 days 2 238.2 mg 2.4 3.39 post excision weight measurement weight scale Thymus gland Changed sex from F to female to standardize across records, 7-30-2024 140006 3292
WKY/NCrl body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 21.0 days 15 39.6 g 1.51 5.84 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140012 3292
WKY/NCrl total body water mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 21.0 days 15 4.29 g 0.09 0.34 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 140025 3292
WKY/NCrl total body water mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 21.0 days 15 10.96 % 0.28 1.09 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 140029 3292
WKY/NCrl total body fat-free mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 15 55.35 g 2.18 8.46 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 140034 3292
WKY/NCrl total body water mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 28.0 days 15 7.33 % 0.13 0.5 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 140037 3292
WKY/NCrl total body lean mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 15 64.55 % 0.33 1.28 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 140036 3292
WKY/NCrl total body fat mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 70.0 days 15 26.33 g 1.08 4.2 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 140039 3292
WKY/NCrl total body water mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 70.0 days 15 18.08 g 0.22 0.83 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 140041 3292
WKY/NCrl total body water mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 70.0 days 15 7.32 % 0.04 0.15 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 140045 3292
WKY/NCrl average daily food intake weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait male 28.0 days 15 11.47 g/d 0.56 2.17 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from M to male to standardize across records, 7-30-2024 140047 3292
WKY/NCrl average daily food intake weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait male 70.0 days 15 19.46 g/d 0.4 1.57 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from M to male to standardize across records, 7-30-2024 140051 3292
WKY/NCrl timed urine mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. urination behavior trait male 70.0 days 15 14.01 g/d 0.92 3.55 metabolic cage urine mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour urine output Changed sex from M to male to standardize across records, 7-30-2024 140053 3292
WKY/NCrl renal fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. renal fat pad mass male 91.0 days 15 5.39 g 0.26 1.01 post excision weight measurement weight scale PWAT Changed sex from M to male to standardize across records, 7-30-2024 140062 3292
WKY/NCrl inguinal fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. inguinal fat pad mass male 91.0 days 15 5.09 g 0.25 0.98 post excision weight measurement weight scale IWAT Changed sex from M to male to standardize across records, 7-30-2024 140063 3292
WKY/NCrl both kidneys wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. kidney mass male 91.0 days 15 2.18 g 0.03 0.11 post excision weight measurement weight scale Total Kidneys Changed sex from M to male to standardize across records, 7-30-2024 140060 3292
WKY/NCrl both testes wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. testis mass male 91.0 days 15 2.6 g 0.02 0.06 post excision weight measurement weight scale Testes Changed sex from M to male to standardize across records, 7-30-2024 140065 3292
WKY/NCrl heart left ventricle weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. heart left ventricle mass male 91.0 days 13 0.79 g 0.01 0.04 post excision weight measurement weight scale Left ventricle of the heart Changed sex from M to male to standardize across records, 7-30-2024 140059 3292
WKY/NCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 0.0 null 0.01 0.02 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15606 381
WKY/NCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 505.34 beats/min 9.87 31.2 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15789 381
WKY/NCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 15 120.33 mmHg 4.38 16.98 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15800 381
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 18.29 beats/min 7.47 18.3 vascular fluid filled catheter 52067 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 2.86 beats/min 18.13 47.96 vascular fluid filled catheter 52077 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -35.03 beats/min 21.41 56.65 vascular fluid filled catheter 52081 481
WKY/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 6 0.37 mg/dl 0.03 0.07 radioimmunoassay 50693 481
WKY/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 391.94 beats/min 27.41 67.15 vascular fluid filled catheter 50711 481
WKY/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 9 0.76 ng/ml/h 0.14 0.41 radioimmunoassay 50712 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -19.05 beats/min 23.28 61.59 vascular fluid filled catheter 51043 481
WKY/NCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 143.53 % 6.68 22.15 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54178 381
WKY/NCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 164.22 % 9.04 29.99 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54189 381
WKY/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 389.36 beats/min 16.31 48.94 vascular fluid filled catheter 51386 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 -3.31 mmHg 2.75 6.73 vascular fluid filled catheter 50382 481
WKY/NCrl plasma creatinine level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data blood creatinine amount female 87.0 days-120.0 days 5 0.42 mg/dl 0.03 0.07 radioimmunoassay 50412 481
WKY/NCrl urine total protein excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data total urine protein amount male 87.0 days-120.0 days 9 21.67 mg/d 3.9 11.7 automated urine analysis 50440 481
WKY/NCrl urine albumin excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine albumin amount male 87.0 days-120.0 days 9 0.76 mg/d 0.07 0.21 automated urine analysis 50466 481
WKY/NCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 12 108.58 mmHg 1.69 5.87 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14291 381
WKY/NCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 -6.81 mmHg 1.37 3.62 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17203 381
WKY/NCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 5 166.8 beats/min 19.28 43.1 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17290 381
WKY/NCrl respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 16 128.31 breaths/min 3.4 13.58 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17321 381
WKY/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 20 %change=VE during7-9 min hypoxia/control during standard conditions 126.16 % 4.99 22.31 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17340 381
WKY/NCrl mean arterial blood pressure controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 15 115.69 mmHg 3.79 14.69 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13883 381
WKY/NCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 3 24.75 mmHg 4.33 7.51 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14060 381
WKY/NCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 3 7.5 null 0.03 0.04 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20852 381
WKY/NCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 153.33 % 5.96 20.65 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53853 381
WKY/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 15 36.81 degrees C 0.19 0.75 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19989 381
WKY/NCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 18.83 mmHg 3.45 10.9 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20110 381
WKY/NCrl heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 14 353.66 beats/min 12.59 47.13 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19537 381
WKY/NCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 85.59 ml/min 6.69 22.19 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17578 381
WKY/NCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 20 32.85 ml/min 2.22 9.91 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17909 381
WKY/NCrl partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 11 56.6 mmHg 1.1 3.65 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17013 381
WKY/NCrl heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 6 379.95 beats/min 14.64 35.87 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18392 381
WKY/NCrl absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 0.02 degrees C 0.2 0.69 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18506 381
WKY/NCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 10 115.25 mmHg 7.93 25.08 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18762 381
WKY/NCrl mean arterial blood pressure resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 97.22 mmHg 3.09 9.78 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18781 381
WKY/NCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 3 -0.01 null 0.01 0.02 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18815 381
WKY/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 51.48 ml/min 3.04 12.17 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18961 381
WKY/NCrl minute ventilation controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 20 40.07 ml/min 2.28 10.19 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18969 381
WKY/NCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 10 159.2 mg/dl 22.51 71.19 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36319 401
WKY/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 9 58.87 % 1.3 3.89 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36351 401
WKY/NCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 9 71.44 mg/dl 3.44 10.31 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36462 401
WKY/NCrl serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 13 17.85 mg/dl 0.74 2.67 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37289 401
WKY/NCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 0.28 ml 0.01 0.03 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19035 381
WKY/NCrl absolute change in body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 0.09 degrees C 0.19 0.61 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18514 381
WKY/NCrl respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 16 162.42 breaths/min 5.6 22.39 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17555 381
WKY/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 %change=VE during 2-3 min hypoxia/control during standard conditions 142.56 % 6.86 27.45 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19299 381
WKY/NCrl time to onset of heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 9 891.59 s 75.57 226.71 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49479 461
WKY/NCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 8 30.88 mmHg 3.33 9.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49587 461
WKY/NCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 90.4 mmHg 6.57 20.77 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49780 461
WKY/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 152.96 mmHg 6.9 20.7 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49800 461
WKY/NCrl hematocrit control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 13 44.69 % 0.51 1.84 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38869 401
WKY/NCrl serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount female 77.0 days-91.0 days 14 0.14 mg/dl 0.01 0.05 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42182 401
WKY/NCrl mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 10 32.12 g/dl 0.17 0.53 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42208 401
WKY/NCrl mean corpuscular hemoglobin concentration control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 13 32.07 g/dl 0.16 0.57 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42215 401
WKY/NCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 9 3.38 x 1000 cells/ul 0.36 1.08 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39496 401
WKY/NCrl mean corpuscular hemoglobin concentration controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 8 32.65 g/dl 0.2 0.56 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42729 401
WKY/NCrl blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 10 0.26 x 1000 cells/ul 0.03 0.09 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43078 401
WKY/NCrl blood monocyte count control condition (for 14 days) PhysGen Biochemistry data monocyte quantity female 77.0 days-91.0 days 13 0.25 x 1000 cells/ul 0.05 0.17 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43085 401
WKY/NCrl body weight anti-glomerular basement membrane antibody (500 ul) Kose H, et al., Exp Anim. 2009 Apr;58(2):193-8. body mass female 64.0 days 10 164.6 g body weighing method 0.0 antibody injection 8 days 67690 307
WKY/NCrl kidney wet weight anti-glomerular basement membrane antibody (500 ul) Kose H, et al., Exp Anim. 2009 Apr;58(2):193-8. kidney mass female 64.0 days 10 1.51 g post excision weight measurement 0.0 antibody injection 8 days 67686 307
WKY/NCrl calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 0.1 mmHg x min x kg x ml-1 0.01 0.02 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59037 526
WKY/NCrl blood eosinophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 8 0.02 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40501 401
WKY/NCrl serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 10 4.27 mmol/l 0.22 0.7 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40645 401
WKY/NCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 9 0.32 mg/dl 0.01 0.04 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40804 401
WKY/NCrl serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 14 104.93 mmol/l 1.26 4.71 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41112 401
WKY/NCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 8 20.25 mmol/l 1.33 3.77 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41121 401
WKY/NCrl serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 13 9.22 mg/dl 0.13 0.45 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37933 401
WKY/NCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 8 10.14 x 10E6 cells/ul 0.3 0.84 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38149 401
WKY/NCrl red blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 9 10.11 x 10E6 cells/ul 0.18 0.55 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38156 401
WKY/NCrl serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount female 77.0 days-91.0 days 14 174.43 U/l 10.89 40.74 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38177 401
WKY/NCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 10 106.3 mmol/l 0.75 2.36 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38180 401
WKY/NCrl blood lymphocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data lymphocyte quantity female 77.0 days-91.0 days 9 2.29 x 1000 cells/ul 0.29 0.86 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38221 401
WKY/NCrl serum alanine aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 9 52.56 U/l 4.46 13.37 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41605 401
WKY/NCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 53.05 % 9.38 29.66 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47528 461
WKY/NCrl FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 8 58.43 ml/min/kg 4.51 12.77 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57459 526
WKY/NCrl FAPGG metabolism-surface area product FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 84.83 ml/min/kg 5.24 18.89 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57466 526
WKY/NCrl methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 0.22 null 0.01 0.05 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57740 526
WKY/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 11 26.44 mmHg 0.64 2.12 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16362 381
WKY/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 11 0.06 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16664 381
WKY/NCrl absolute change in blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 10 0.07 null 0.0 0.01 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16672 381
WKY/NCrl maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 15 1.55 g/mg 0.09 0.37 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55857 522
WKY/NCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 0.66 E-7mole 0.27 0.77 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55985 522
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 14.56 % 6.39 19.16 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54637 522
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 22.44 % 6.49 19.46 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56044 522
WKY/NCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 0.33 null 0.03 0.08 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58579 526
WKY/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 8 60.23 % 1.66 4.7 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58582 526
WKY/NCrl lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass male 77.0 days-91.0 days 9 0.86 g/kg 0.04 0.12 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58824 526
WKY/NCrl lung dry weight to body weight ratio control condition (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 19 1.06 g/kg 0.02 0.09 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58831 526
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 -7.97 null 0.09 0.35 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55111 522
WKY/NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 0.05 10E-7mol/l 0.02 0.06 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56459 522
WKY/NCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 10 0.39 null 0.03 0.09 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59973 526
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 18 70.67 % 3.59 15.22 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56754 522
WKY/NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 0.05 10E-7mol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56769 522
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 15 -7.45 null 0.09 0.33 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56772 522
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 18 -7.63 null 0.06 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56779 522
WKY/NCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 14 -7.48 null 0.06 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56815 522
WKY/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait female 77.0 days-91.0 days 11 1.0 mg/kg 0.18 0.61 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60113 526
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 15 99.27 % 0.6 2.31 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57116 522
WKY/NCrl tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 0.32 ml 0.01 0.06 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16031 381
WKY/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 65.74 mmHg 10.94 30.96 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45901 461
WKY/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 72.86 mmHg 12.86 40.67 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45909 461
WKY/NCrl percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 71.45 % 2.96 8.89 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46170 461
WKY/NCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 5.63 mmHg 0.16 0.49 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48164 461
WKY/NCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 9 1.09 g 0.04 0.13 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45028 461
WKY/NCrl percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 28.35 % 5.95 17.84 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45048 461
WKY/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 15.58 ml/min/g 0.62 1.85 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45081 461
WKY/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 14.76 ml/min/g 1.11 3.49 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45089 461
WKY/NCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 44.53 mmHg 4.42 13.27 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47403 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 0.42 IU/g 0.08 0.27 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48385 461
WKY/NCrl systolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to ambient light (for 14 days) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126.0 days 7 126.4 mmHg 1.06 2.8 vascular indwelling catheter method left common carotid artery 0.0 daytime (7 AM - 7 PM) 70085 1281
WKY/NCrl systolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to darkness (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126.0 days 7 131.7 mmHg 0.83 2.2 vascular indwelling catheter method left common carotid artery 0.0 nighttime (7 PM - 7 AM) 70086 1281
WKY/NCrl diastolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to ambient light (for 14 days) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126.0 days 7 89.3 mmHg 0.76 2.0 vascular indwelling catheter method left common carotid artery 0.0 daytime (7 AM - 7 PM) 70087 1281
WKY/NCrl body weight control condition Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. body mass male 140.0 days 6 436.0 g 6.0 14.7 body weighing method 0.0 103486 2827
WKY/NCrl body weight salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. body mass male 168.0 days 6 462.0 g 6.0 14.7 body weighing method 0.0 103491 2827
WKY/NCrl blood glucose level fasting (for 16 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 134.0 days 6 98.0 mg/dl 3.0 7.35 blood glucose test strip read by electrochemical glucometer 0.0 103507 2827
WKY/NCrl blood glucose level vehicle control condition (for 28 days) then fasting (for 16 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 168.0 days 6 113.0 mg/dl 4.0 9.8 blood glucose test strip read by electrochemical glucometer 0.0 103510 2827
WKY/NCrl blood glucose level fasting (for 16 hours) then glucose (2 g/kg) (for 2 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 134.0 days 6 118.0 mg/dl 4.0 9.8 oral glucose tolerance test 0.0 103515 2827
WKY/NCrl systolic blood pressure vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168.0 days 6 126.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry measured 12 hr/night for 4 weeks nighttime measurement 103534 2827
WKY/NCrl diastolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168.0 days 6 85.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry measured 12 hr/day for 4 weeks daytime measurement 103542 2827
WKY/NCrl diastolic blood pressure salidroside (40 mg/kg) (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168.0 days 6 83.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry measured 12 hr/day for 4 weeks daytime measurement 103543 2827
WKY/NCrl heart rate vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168.0 days 6 294.0 beats/min 5.0 12.25 intra-aortic abdominal radiotelemetry measured 12 hr/day for 4 weeks daytime measurement 103558 2827
WKY/NCrl number of spontaneous locomotor movements per unit time control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. locomotor behavior trait male 140.0 days 6 1.0 /min 0.2 0.49 intra-aortic abdominal radiotelemetry 0.0 number of spontaneous locomotor movements per unit time (CMO:0003644) 103570 2827
WKY/NCrl number of spontaneous locomotor movements per unit time salidroside (40 mg/kg) (between 1 and 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. locomotor behavior trait male 168.0 days 6 1.0 /min 0.1 0.24 intra-aortic abdominal radiotelemetry measured 12 hr/day for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103575 2827
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 98.36 % 0.98 2.59 wire myography 0.0 103599 2827
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 -8.15 null 0.09 0.24 wire myography 0.0 103610 2827
WKY/NCrl absolute change in mean arterial blood pressure artificial cerebrospinal fluid (200 nl) then angiotensin II (90 ng) then candesartan (0.5 ug) (for 0.2 hours) then angiotensin II (90 ng) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. arterial blood pressure trait not specified  days 4 1.0 mmHg 1.0 2.0 vascular fluid filled catheter 0.0 110106 2685
WKY/NCrl thyroid gland wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. thyroid gland mass male 91.0 days 12 11.33 mg 0.39 1.35 post excision weight measurement weight scale Thyroid gland Changed sex from M to male to standardize across records, 7-30-2024 140067 3292
WKY/NCrl serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount male 91.0 days 10 115.89 µg/dL 3.88 12.28 radioimmunoassay RIA; RRID:AB_2940789 Serum total T3 Changed sex from M to male to standardize across records, 7-30-2024 140071 3292
WKY/NCrl serum thyroxine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood thyroxine amount male 91.0 days 10 4.46 ng/dL 0.14 0.46 radioimmunoassay RIA; RRID:AB_2940788 Serum total T4 Changed sex from M to male to standardize across records, 7-30-2024 140072 3292
WKY/NCrl body mass index (BMI) controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 91.0 days 15 0.59 g/cm2 0.0 0.02 body weighing method "weight scale, tape measure" Body Mass Index (BMI) Changed sex from M to male to standardize across records, 7-30-2024 140075 3292
WKY/NCrl body weight control condition (0 null) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 14.0 days 15 23.32 g 0.56 2.19 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140077 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 28 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 49.0 days 15 160.4 g 3.39 13.14 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140082 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 21 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 42.0 days 15 124.87 g 2.65 10.25 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140081 3292
WKY/NCrl total body fat mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 21.0 days 15 4.87 g 0.36 1.4 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 140089 3292
WKY/NCrl total body water mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 21.0 days 15 4.22 g 0.08 0.32 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 140091 3292
WKY/NCrl total body fat mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 28.0 days 15 11.64 g 0.63 2.45 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 140097 3292
WKY/NCrl total body lean mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 15 64.81 % 0.32 1.25 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 140102 3292
WKY/NCrl defecation rate by mass controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait male 70.0 days 15 3.66 g/d 0.18 0.71 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from M to male to standardize across records, 7-30-2024 140120 3292
WKY/NCrl body weight gain to calories absorbed ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. food conversion trait male 70.0 days 15 0.33 g/kcal 0.01 0.04 constant volume calorimetry "Body weight gain, bomb calorimetry"; Bomb calorimetry data from 4 and 10 weeks were combined with body weight gain data; body weight gained per calorie absorbed Energy efficiency Changed sex from M to male to standardize across records, 7-30-2024 140122 3292
WKY/NCrl timed urine mass controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. urination behavior trait male 70.0 days 14 14.75 g/d 0.77 2.86 metabolic cage urine mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour urine output Changed sex from M to male to standardize across records, 7-30-2024 140119 3292
WKY/NCrl epididymal fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. epididymal fat pad mass male 91.0 days 15 3.51 g 0.1 0.38 post excision weight measurement weight scale GWAT Changed sex from M to male to standardize across records, 7-30-2024 140127 3292
WKY/NCrl systolic blood pressure vehicle control condition (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168.0 days 6 121.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry measured 12 hr/day for 4 weeks daytime measurement 103526 2827
WKY/NCrl systolic blood pressure salidroside (40 mg/kg) (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168.0 days 6 117.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry measured 12 hr/day for 4 weeks daytime measurement 103527 2827
WKY/NCrl systolic blood pressure control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133.0 days-140.0 days 6 122.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry 0.0 measured 12 hr/night for 1 week nighttime measurement 103531 2827
WKY/NCrl body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 7.0 days 10 10.07 g 0.56 1.77 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139881 3292
WKY/NCrl total body fat mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 21.0 days 10 5.69 g 0.37 1.15 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 139894 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 56 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 77.0 days 10 183.1 g 2.89 9.15 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139891 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 70.0 days 10 171.6 g 2.82 8.92 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139890 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 91.0 days 10 199.7 g 3.39 10.73 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139893 3292
WKY/NCrl total body fat-free mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 34.71 g 1.21 3.83 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 139897 3292
WKY/NCrl total body fat mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 28.0 days 10 11.85 g 0.67 2.12 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 139902 3292
WKY/NCrl defecation rate by mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait female 28.0 days 10 1.74 g/d 0.05 0.17 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from F to female to standardize across records, 7-30-2024 139920 3292
WKY/NCrl calculated water drink intake volume controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait female 28.0 days 10 17.4 mL/d 1.28 4.03 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from F to female to standardize across records, 7-30-2024 139919 3292
WKY/NCrl heart left ventricle weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. heart left ventricle mass female 91.0 days 10 0.58 g 0.04 0.13 post excision weight measurement weight scale Left ventricle of the heart Changed sex from F to female to standardize across records, 7-30-2024 139930 3292
WKY/NCrl body length, nose to tail controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length female 91.0 days 10 36.57 cm 0.27 0.86 body length measuring method tape measure Nose:tail body length Changed sex from F to female to standardize across records, 7-30-2024 139945 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 70.0 days 10 171.6 g 2.32 7.35 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139956 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 42 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 63.0 days 10 160.7 g 2.32 7.33 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139955 3292
WKY/NCrl total body water mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 21.0 days 10 3.98 g 0.07 0.21 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 139962 3292
WKY/NCrl total body fat-free mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 34.18 g 1.08 3.41 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 139963 3292
WKY/NCrl total body fat-free mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 52.52 g 2.26 7.16 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 139971 3292
WKY/NCrl total body lean mass controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 70.0 days 10 110.97 g 1.4 4.44 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 139977 3292
WKY/NCrl total body fat-free mass controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 70.0 days 9 153.24 g 1.44 4.33 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 139979 3292
WKY/NCrl total body lean mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 70.0 days 10 63.93 % 0.56 1.77 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 139981 3292
WKY/NCrl total body fat-free mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 70.0 days 9 88.74 % 0.2 0.61 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 139983 3292
WKY/NCrl defecation rate by mass controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait female 70.0 days 10 2.55 g/d 0.17 0.54 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from F to female to standardize across records, 7-30-2024 139991 3292
WKY/NCrl heart left ventricle weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. heart left ventricle mass female 91.0 days 10 0.55 g 0.01 0.04 post excision weight measurement weight scale Left ventricle of the heart Changed sex from F to female to standardize across records, 7-30-2024 139996 3292
WKY/NCrl both kidneys wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. kidney mass female 91.0 days 10 1.41 g 0.03 0.1 post excision weight measurement weight scale Total Kidneys Changed sex from F to female to standardize across records, 7-30-2024 139997 3292
WKY/NCrl epididymal fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. epididymal fat pad mass female 91.0 days 10 2.37 g 0.1 0.31 post excision weight measurement weight scale GWAT Changed sex from F to female to standardize across records, 7-30-2024 139998 3292
WKY/NCrl both ovaries wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. ovary mass female 91.0 days 10 86.03 mg 2.77 8.77 post excision weight measurement weight scale Ovaries Changed sex from F to female to standardize across records, 7-30-2024 140002 3292
WKY/NCrl thyroid gland wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. thyroid gland mass female 91.0 days 9 10.29 mg 0.37 1.11 post excision weight measurement weight scale Thyroid gland Changed sex from F to female to standardize across records, 7-30-2024 140004 3292
WKY/NCrl both adrenal glands wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. adrenal gland mass female 91.0 days 9 58.13 mg 2.03 6.08 post excision weight measurement weight scale Adrenal glands Changed sex from F to female to standardize across records, 7-30-2024 140003 3292
WKY/NCrl body mass index (BMI) controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 91.0 days 10 0.48 g/cm2 0.0 0.01 body weighing method "weight scale, tape measure" Body Mass Index (BMI) Changed sex from F to female to standardize across records, 7-30-2024 140009 3292
WKY/NCrl body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 14.0 days 15 23.38 g 0.62 2.42 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140011 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 63 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 84.0 days 15 286.6 g 3.44 13.31 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140021 3292
WKY/NCrl total body fat-free mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 15 34.73 g 1.14 4.42 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 140026 3292
WKY/NCrl total body water mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 28.0 days 15 4.92 g 0.18 0.7 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 140033 3292
WKY/NCrl total body fat-free mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 15 220.81 g 2.74 10.63 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 140042 3292
WKY/NCrl defecation rate by mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait male 28.0 days 15 1.81 g/d 0.11 0.41 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from M to male to standardize across records, 7-30-2024 140049 3292
WKY/NCrl calculated water drink intake volume controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait male 70.0 days 15 28.0 mL/d 0.93 3.59 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from M to male to standardize across records, 7-30-2024 140052 3292
WKY/NCrl partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 12 90.42 mmHg 2.13 7.39 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15558 381
WKY/NCrl body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 37.55 degrees C 0.11 0.33 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15577 381
WKY/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 7 26.89 mmHg 0.85 2.25 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15631 381
WKY/NCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 5 440.1 beats/min 13.78 30.81 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15781 381
WKY/NCrl partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 12 34.63 mmHg 0.56 1.96 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15367 381
WKY/NCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 0.27 ml 0.02 0.07 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14428 381
WKY/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 %change=VE during7-9 min hypercapnia/control during standard conditions 261.31 % 20.11 69.66 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15215 381
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 118.69 mmHg 1.08 3.25 vascular fluid filled catheter 51877 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 0.66 mmHg 4.15 10.16 vascular fluid filled catheter 51995 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -33.41 beats/min 13.0 39.01 vascular fluid filled catheter 52074 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -73.2 beats/min 18.38 55.13 vascular fluid filled catheter 52078 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -27.44 beats/min 13.68 36.19 vascular fluid filled catheter 50729 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 14.15 mmHg 3.96 11.89 vascular fluid filled catheter 50828 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -99.06 beats/min 19.83 52.45 vascular fluid filled catheter 50832 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -112.24 beats/min 36.62 89.69 vascular fluid filled catheter 50835 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 0.02 mmHg 3.23 8.55 vascular fluid filled catheter 50831 481
WKY/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 9 12.18 mEq/d 0.61 1.82 flame atomic emission spectrometry 50869 481
WKY/NCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 162.06 % 5.85 20.26 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54184 381
WKY/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 114.92 % 5.05 20.18 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54200 381
WKY/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 430.77 beats/min 14.45 38.23 vascular fluid filled catheter 51389 481
WKY/NCrl body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 11 36.55 degrees C 0.31 1.03 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14172 381
WKY/NCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 114.08 beats/min 3.93 6.8 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17295 381
WKY/NCrl absolute change in partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 15.83 mmHg 3.84 10.87 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14055 381
WKY/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 49.48 ml/min 1.51 6.04 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19715 381
WKY/NCrl body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 20 37.33 degrees C 0.15 0.67 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19948 381
WKY/NCrl body temperature controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 20 36.97 degrees C 0.25 1.13 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19997 381
WKY/NCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 31.11 mmHg 5.82 14.27 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20102 381
WKY/NCrl heart rate control condition PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 15 367.53 beats/min 15.04 58.24 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19545 381
WKY/NCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 76.91 ml/min 3.35 11.61 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19592 381
WKY/NCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 103.69 mmHg 4.74 8.22 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17602 381
WKY/NCrl blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 10 7.49 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 18992 381
WKY/NCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 9 5.69 g/dl 0.11 0.32 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36268 401
WKY/NCrl mean corpuscular volume controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 9 58.22 fl 0.68 2.05 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36292 401
WKY/NCrl blood neutrophil count control condition (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 10 0.96 x 1000 cells/ul 0.16 0.51 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36297 401
WKY/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data erythrocyte quantity male 77.0 days-91.0 days 8 60.23 % 1.66 4.7 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36344 401
WKY/NCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 20 0.25 ml 0.01 0.05 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19043 381
WKY/NCrl respiration rate control condition PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 133.84 breaths/min 7.12 23.62 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18154 381
WKY/NCrl heart weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass male 49.0 days-63.0 days 9 7.5 g/kg 0.39 1.17 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49143 461
WKY/NCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 70.12 % 10.38 31.14 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49260 461
WKY/NCrl percent change in heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 96.97 % 8.23 26.01 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49268 461
WKY/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 152.7 mmHg 5.6 17.71 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49808 461
WKY/NCrl serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount male 77.0 days-91.0 days 10 8.45 mg/dl 0.64 2.03 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38834 401
WKY/NCrl serum phosphate level control condition (for 14 days) PhysGen Biochemistry data blood phosphate amount female 77.0 days-91.0 days 13 7.62 mg/dl 0.22 0.78 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38841 401
WKY/NCrl serum total bilirubin level control condition (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 10 0.17 mg/dl 0.02 0.05 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42175 401
WKY/NCrl plasma anion gap control condition (for 14 days) PhysGen Biochemistry data ion homeostasis trait male 77.0 days-91.0 days 10 18.9 mmol/l 1.46 4.63 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42356 401
WKY/NCrl serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 10 3.67 g/dl 0.04 0.13 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39347 401
WKY/NCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 10 18.9 mg/dl 0.91 2.88 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39511 401
WKY/NCrl plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 10 0.27 mg/dl 0.03 0.09 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39551 401
WKY/NCrl serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 14 24.21 mmol/l 0.77 2.89 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43075 401
WKY/NCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 165.12 % 7.37 25.53 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54536 381
WKY/NCrl percent change in tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 173.91 % 11.41 37.85 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54541 381
WKY/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 20 125.73 % 4.17 18.66 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53599 381
WKY/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 16 127.08 % 4.06 16.25 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53604 381
WKY/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 20 111.74 % 2.95 13.19 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53610 381
WKY/NCrl serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount male 77.0 days-91.0 days 9 171.89 mg/dl 8.18 24.53 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40485 401
WKY/NCrl serum glucose level control condition (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 14 166.14 mg/dl 10.52 39.36 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40492 401
WKY/NCrl serum total bilirubin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bilirubin amount male 77.0 days-91.0 days 8 0.33 mg/dl 0.05 0.15 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37541 401
WKY/NCrl mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait female 77.0 days-91.0 days 13 53.36 fl 0.24 0.88 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37794 401
WKY/NCrl serum bicarbonate level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood bicarbonate amount female 77.0 days-91.0 days 9 19.67 mmol/l 0.58 1.73 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41128 401
WKY/NCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount male 77.0 days-91.0 days 9 3.53 g/dl 0.03 0.09 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41131 401
WKY/NCrl serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 14 114.21 mg/dl 3.56 13.31 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37912 401
WKY/NCrl serum calcium level control condition (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 10 9.28 mg/dl 0.07 0.23 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37926 401
WKY/NCrl serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 10 96.1 U/l 5.95 18.83 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41610 401
WKY/NCrl serum aspartate aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 14 85.07 U/l 3.89 14.56 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41617 401
WKY/NCrl blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity male 77.0 days-91.0 days 10 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38344 401
WKY/NCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 8 19.68 g/dl 0.56 1.6 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38399 401
WKY/NCrl blood hemoglobin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 19.02 g/dl 0.41 1.22 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38406 401
WKY/NCrl percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 85.11 % 6.04 19.11 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47548 461
WKY/NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 14 0.05 umol/l 0.01 0.03 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57425 522
WKY/NCrl methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 13.65 ml/min/kg 1.26 4.53 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57456 526
WKY/NCrl lung dry weight to body weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data lung mass female 77.0 days-91.0 days 10 1.41 g/kg 0.02 0.07 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57580 526
WKY/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 15 356.09 beats/min 15.89 61.56 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16129 381
WKY/NCrl body weight control condition (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 9 192.0 g 4.1 12.3 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57701 526
WKY/NCrl dose of methacholine at which pulmonary conductance is half its pretreatment value controlled air oxygen content (12 %) (for 14 days) then methacholine (0-11.06 mg/kg) and drug dose time series (for 0.2 hours) PhysGen Lung data pulmonary ventilation trait male 77.0 days-91.0 days 9 1.5 mg/kg 0.28 0.84 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57763 526
WKY/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait female 77.0 days-91.0 days 10 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58089 526
WKY/NCrl body weight control condition PhysGen Respiratory data body mass male 82.0 days-99.0 days 23 242.3 g 6.1 29.1 whole body digital scale Moms and pups used in studies were fed Dyets 16786 381
WKY/NCrl body weight control condition PhysGen Respiratory data body mass female 82.0 days-99.0 days 22 174.4 g 3.5 16.4 whole body digital scale Moms and pups used in studies were fed Dyets 16794 381
WKY/NCrl methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 18.51 ml/min/kg 1.21 4.38 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58311 526
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 22.92 % 5.42 18.77 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54644 522
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 8 -7.47 null 0.2 0.56 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54750 522
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 36.42 % 6.33 21.94 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56051 522
WKY/NCrl body weight control condition (for 21 days) PhysGen Vascular data body mass male 70.0 days-84.0 days 15 247.4 g 7.8 30.4 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54869 522
WKY/NCrl methylene blue metabolism-surface area product without auto-oxidation controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 12.88 ml/min/kg 1.79 5.37 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58834 526
WKY/NCrl hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 11 44.32 % 0.29 0.97 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59857 526
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 9 59.89 % 3.99 11.96 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56681 522
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 71.9 % 3.29 10.42 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56710 522
WKY/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass male 77.0 days-91.0 days 10 184.9 g 10.2 32.2 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60096 526
WKY/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 10 175.3 g 4.5 14.3 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60103 526
WKY/NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 14 0.04 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56997 522
WKY/NCrl percent change in arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 72.19 % 4.69 14.82 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45852 461
WKY/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 33.16 mmHg 4.85 15.35 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45939 461
WKY/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 5.52 mmHg 0.06 0.17 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48006 461
WKY/NCrl left ventricular diastolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 5.47 mmHg 0.12 0.38 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48014 461
WKY/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 10.66 ml/min/g 0.63 1.9 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46150 461
WKY/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait male 49.0 days-63.0 days 9 8.38 ml/min/g 0.69 2.08 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46174 461
WKY/NCrl body weight control condition PhysGen Cardiac data body mass male 49.0 days-63.0 days 10 179.6 g 5.8 18.3 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47159 461
WKY/NCrl body weight control condition PhysGen Cardiac data body mass female 49.0 days-63.0 days 10 151.3 g 4.3 13.6 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47166 461
WKY/NCrl heart wet weight control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 0.95 g 0.06 0.18 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48141 461
WKY/NCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 6.01 mmHg 0.12 0.39 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48156 461
WKY/NCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 1156.24 s 65.58 185.48 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45101 461
WKY/NCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 39.11 mmHg 7.44 23.54 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47399 461
WKY/NCrl left ventricular diastolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 52.36 mmHg 3.71 11.72 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47411 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 0.36 IU/g 0.06 0.2 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45238 461
WKY/NCrl diastolic blood pressure controlled exposure to darkness (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 112.0 days 7 92.5 mmHg 1.59 4.2 vascular indwelling catheter method left common carotid artery 0.0 nighttime (7 PM - 7 AM) 70084 1281
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 28 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 49.0 days 10 131.0 g 2.13 6.73 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139887 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 63 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 84.0 days 10 192.6 g 2.83 8.93 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139892 3292
WKY/NCrl total body water mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 21.0 days 10 10.05 % 0.26 0.83 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 139900 3292
WKY/NCrl total body water mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 28.0 days 10 4.77 g 0.26 0.83 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 139904 3292
WKY/NCrl total body fat-free mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 70.0 days 9 151.86 g 1.05 3.14 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 139913 3292
WKY/NCrl total body water mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 70.0 days 10 12.86 g 0.24 0.76 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 139912 3292
WKY/NCrl average daily food intake weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait female 28.0 days 9 11.1 g/d 0.17 0.5 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from F to female to standardize across records, 7-30-2024 139918 3292
WKY/NCrl total body lean mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 70.0 days 10 64.3 % 0.58 1.82 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 139915 3292
WKY/NCrl average daily food intake weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait female 70.0 days 10 15.18 g/d 0.46 1.45 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from F to female to standardize across records, 7-30-2024 139922 3292
WKY/NCrl blood glucose level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) then fasting (for 16 hours) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood glucose amount female 91.0 days 10 69.8 mg/dl 1.55 4.92 blood glucose test strip read by electrochemical glucometer "overnight fast, saphenous vien "; "animals were fasted overnight (~16 hours), hind left leg shaved, pricked saphenous vein using a lancet, used glucometer to measure blood glucose" Fasted blood glucose Changed sex from F to female to standardize across records, 7-30-2024 139928 3292
WKY/NCrl inguinal fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. inguinal fat pad mass female 91.0 days 10 2.78 g 0.11 0.35 post excision weight measurement weight scale IWAT Changed sex from F to female to standardize across records, 7-30-2024 139934 3292
WKY/NCrl both ovaries wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. ovary mass female 91.0 days 10 86.44 mg 1.98 6.27 post excision weight measurement weight scale Ovaries Changed sex from F to female to standardize across records, 7-30-2024 139936 3292
WKY/NCrl body length, nose to rump controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length female 91.0 days 10 20.24 cm 0.12 0.38 body length measuring method tape measure Nose:Rump body length Changed sex from F to female to standardize across records, 7-30-2024 139944 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 28.0 days 10 61.3 g 2.57 8.12 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139950 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 21 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 42.0 days 10 109.4 g 1.77 5.58 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139952 3292
WKY/NCrl total body lean mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 65.11 % 0.7 2.22 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 139965 3292
WKY/NCrl total body fat-free mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 86.02 % 0.61 1.91 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 139967 3292
WKY/NCrl total body lean mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 41.15 g 1.72 5.45 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 139969 3292
WKY/NCrl total body fat-free mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 81.23 % 0.53 1.66 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 139975 3292
WKY/NCrl total body lean mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 63.67 % 0.51 1.6 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 139973 3292
WKY/NCrl total body water mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 70.0 days 10 7.4 % 0.07 0.22 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 139982 3292
WKY/NCrl average daily food intake weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait female 70.0 days 10 14.81 g/d 0.75 2.37 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from F to female to standardize across records, 7-30-2024 139988 3292
WKY/NCrl calories absorbed to calorie intake ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait female 70.0 days 10 88.05 % 0.6 1.88 constant volume calorimetry Bomb calorimetry; 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food Digestive efficiency Changed sex from F to female to standardize across records, 7-30-2024 139992 3292
WKY/NCrl pituitary gland wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. pituitary gland mass female 91.0 days 10 0.01 g 0.0 0.0 post excision weight measurement weight scale Pituitary gland Changed sex from F to female to standardize across records, 7-30-2024 140005 3292
WKY/NCrl body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 7.0 days 15 10.48 g 0.42 1.61 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140010 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 28 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 49.0 days 15 161.4 g 2.55 9.86 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140016 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 70.0 days 15 242.67 g 3.04 11.78 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140019 3292
WKY/NCrl total body fat mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 21.0 days 15 4.87 g 0.38 1.49 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 140023 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 56 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 77.0 days 15 266.47 g 3.63 14.07 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140020 3292
WKY/NCrl total body lean mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 15 26.39 g 0.82 3.17 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 140024 3292
WKY/NCrl total body fat mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 28.0 days 15 12.05 g 0.65 2.51 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 140031 3292
WKY/NCrl total body lean mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 15 66.92 % 0.65 2.51 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 140028 3292
WKY/NCrl total body lean mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 15 43.4 g 1.65 6.38 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 140032 3292
WKY/NCrl body weight gain to calories absorbed ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. food conversion trait male 70.0 days 15 0.33 g/kcal 0.01 0.03 constant volume calorimetry "Body weight gain, bomb calorimetry"; Bomb calorimetry data from 4 and 10 weeks were combined with body weight gain data; body weight gained per calorie absorbed Energy efficiency Changed sex from M to male to standardize across records, 7-30-2024 140056 3292
WKY/NCrl epididymal fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. epididymal fat pad mass male 91.0 days 14 3.58 g 0.15 0.56 post excision weight measurement weight scale GWAT Changed sex from M to male to standardize across records, 7-30-2024 140061 3292
WKY/NCrl systolic blood pressure control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133.0 days-140.0 days 6 126.0 mmHg 4.0 9.8 intra-aortic abdominal radiotelemetry 0.0 measured 12 hr/night for 1 week nighttime measurement 103530 2827
WKY/NCrl serum fructosamine level vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood fructosamine amount male 175.0 days 6 153.0 umol/l 3.0 7.35 serum fructosamine analysis 0.0 103502 2827
WKY/NCrl diastolic blood pressure control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133.0 days-140.0 days 6 85.0 mmHg 4.0 9.8 intra-aortic abdominal radiotelemetry 0.0 measured 12 hr/day for 1 week daytime measurement 103538 2827
WKY/NCrl diastolic blood pressure vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168.0 days 6 89.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry measured 12 hr/night for 4 weeks nighttime measurement 103550 2827
WKY/NCrl number of spontaneous locomotor movements per unit time control condition and dark phase of controlled light/dark cycle (for 3 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. locomotor behavior trait male 140.0 days 6 3.1 /min 0.3 0.73 intra-aortic abdominal radiotelemetry 0.0 measured 12 hr/night number of spontaneous locomotor movements per unit time (CMO:0003644) 103578 2827
WKY/NCrl number of spontaneous locomotor movements per unit time control condition and dark phase of controlled light/dark cycle (for 3 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. locomotor behavior trait male 140.0 days 6 3.8 /min 0.3 0.73 intra-aortic abdominal radiotelemetry 0.0 measured 12 hr/night number of spontaneous locomotor movements per unit time (CMO:0003644) 103579 2827
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 -8.06 null 0.05 0.13 wire myography 0.0 103594 2827
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 96.54 % 1.9 5.03 wire myography 0.0 103614 2827
WKY/NCrl mesenteric artery phosphorylated eNOS level to total eNOS level ratio vehicle control condition (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. artery molecular composition trait male 175.0 days 7 0.94 null 0.13 0.34 western blot assay 0.0 103622 2827
WKY/NCrl mesenteric artery phosphorylated eNOS level to total eNOS level ratio salidroside (40 mg/kg) (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. artery molecular composition trait male 175.0 days 7 0.88 null 0.08 0.21 western blot assay 0.0 103623 2827
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel control condition Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasodilation trait male 84.0 days 10 81.1 % 3.0 9.49 wire myography 0.0 109367 3141
WKY/NCrl negative logarithm of the molar concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value control condition Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasoconstriction trait male 84.0 days 10 7.8 null 0.2 0.63 wire myography 0.0 logarithm of the concentration of norepinephrine at which the force of blood vessel contraction is half the maximum value (CMO:0003677) 109382 3141
WKY/NCrl heart rate standard condition (for 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. heart pumping trait male 203.0 days-224.0 days 10 307.0 beats/min 24.0 75.89 tail cuff plethysmography 0.0 standard rat chow 107120 3075
WKY/NCrl absolute change in heart rate artificial cerebrospinal fluid (200 nl) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. heart pumping trait not specified  days 7 9.0 beats/min 4.0 10.58 vascular fluid filled catheter 0.0 110107 2685
WKY/NCrl pituitary gland wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. pituitary gland mass male 91.0 days 15 0.01 g 0.0 0.0 post excision weight measurement weight scale Pituitary gland Changed sex from M to male to standardize across records, 7-30-2024 140068 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 56 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 77.0 days 15 264.8 g 3.7 14.34 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140086 3292
WKY/NCrl total body lean mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 15 26.21 g 0.79 3.08 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 140090 3292
WKY/NCrl total body fat-free mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 15 55.36 g 2.18 8.44 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 140100 3292
WKY/NCrl total body fat mass controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 70.0 days 15 25.12 g 1.15 4.45 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 140105 3292
WKY/NCrl total body fat-free mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 15 82.73 % 0.3 1.16 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 140104 3292
WKY/NCrl average daily food intake weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait male 70.0 days 14 19.07 g/d 0.59 2.22 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from M to male to standardize across records, 7-30-2024 140117 3292
WKY/NCrl liver wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. liver mass male 91.0 days 15 9.53 g 0.28 1.07 post excision weight measurement weight scale Liver Changed sex from M to male to standardize across records, 7-30-2024 140124 3292
WKY/NCrl body length, nose to rump controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length male 91.0 days 15 22.57 cm 0.09 0.36 body length measuring method tape measure Nose:Rump body length Changed sex from M to male to standardize across records, 7-30-2024 140136 3292
WKY/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 %change=VE during7-9 min hypercapnia/control during standard conditions 251.95 % 23.95 79.44 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15207 381
WKY/NCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 32.02 ml/min 2.42 8.38 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15495 381
WKY/NCrl tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 0.43 ml 0.03 0.11 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15523 381
WKY/NCrl tidal volume controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 0.4 ml 0.02 0.05 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15531 381
WKY/NCrl partial pressure of blood oxygen resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 10 90.25 mmHg 2.7 8.53 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15566 381
WKY/NCrl body temperature resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data body temperature trait male 82.0 days-99.0 days 12 37.32 degrees C 0.1 0.34 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15569 381
WKY/NCrl tidal volume control condition PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 0.25 ml 0.01 0.04 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14436 381
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -21.91 beats/min 14.45 38.22 vascular fluid filled catheter 51679 481
WKY/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 390.89 beats/min 8.33 20.42 vascular fluid filled catheter 51783 481
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 119.18 mmHg 4.08 10.0 vascular fluid filled catheter 51909 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 -1.91 mmHg 2.6 6.36 vascular fluid filled catheter 51917 481
WKY/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 9 1.5 ml/min 0.15 0.45 urine creatinine analysis 52027 481
WKY/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 370.41 beats/min 5.95 15.75 vascular fluid filled catheter 52034 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -11.5 beats/min 9.79 29.36 vascular fluid filled catheter 52064 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -71.1 beats/min 33.5 82.05 vascular fluid filled catheter 50518 481
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 110.54 mmHg 5.19 13.72 vascular fluid filled catheter 50549 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -33.83 beats/min 18.34 48.53 vascular fluid filled catheter 50550 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -29.03 beats/min 26.41 64.69 vascular fluid filled catheter 50732 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 24.53 mmHg 3.8 11.4 vascular fluid filled catheter 50768 481
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 103.89 mmHg 5.5 16.51 vascular fluid filled catheter 50836 481
WKY/NCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 156.24 % 6.63 22.96 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54173 381
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 1.07 mmHg 3.41 10.22 vascular fluid filled catheter 51394 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 7 -31.0 beats/min 19.2 50.79 vascular fluid filled catheter 51414 481
WKY/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 8 1.16 mEq/d 0.2 0.56 flame atomic emission spectrometry 50439 481
WKY/NCrl mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 10 117.67 mmHg 6.65 21.03 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13448 381
WKY/NCrl absolute change in mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 3 9.35 mmHg 4.99 8.65 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14289 381
WKY/NCrl absolute change in body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 -0.24 degrees C 0.17 0.59 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13872 381
WKY/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 0.32 ml 0.01 0.04 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14007 381
WKY/NCrl blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 7 7.5 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 14050 381
WKY/NCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 108.95 beats/min 10.41 32.92 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14117 381
WKY/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 11 -6.02 mmHg 0.58 1.94 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20979 381
WKY/NCrl absolute change in partial pressure of blood carbon dioxide controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 10 -7.3 mmHg 0.53 1.69 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20987 381
WKY/NCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 10 116.05 mmHg 5.37 16.99 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20137 381
WKY/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 11 -48.24 mmHg 2.65 8.8 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20685 381
WKY/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 10 33.73 mmHg 0.93 2.94 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19690 381
WKY/NCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 79.49 ml/min 3.65 12.64 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17586 381
WKY/NCrl minute ventilation control condition PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 35.59 ml/min 1.71 6.82 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17901 381
WKY/NCrl heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 7 385.12 beats/min 18.61 49.23 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18086 381
WKY/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 11 7.54 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18097 381
WKY/NCrl heart rate control condition PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 10 366.51 beats/min 19.08 60.32 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18384 381
WKY/NCrl absolute change in blood pH resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 8 -0.03 null 0.01 0.03 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18810 381
WKY/NCrl blood pH resting on treadmill (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 12 7.49 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms and pups used in studies were fed Dyets 18984 381
WKY/NCrl serum glucose level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood glucose amount female 77.0 days-91.0 days 9 188.56 mg/dl 14.73 44.19 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36326 401
WKY/NCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 8 19.36 pg 0.15 0.43 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36354 401
WKY/NCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount female 77.0 days-91.0 days 9 86.11 U/l 6.2 18.59 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37429 401
WKY/NCrl tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 0.46 ml 0.04 0.12 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18517 381
WKY/NCrl tidal volume controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 12 0.41 ml 0.02 0.06 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18525 381
WKY/NCrl serum total cholesterol level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood cholesterol amount female 77.0 days-91.0 days 9 90.89 mg/dl 2.32 6.95 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36469 401
WKY/NCrl red blood cell count control condition (for 14 days) PhysGen Biochemistry data erythrocyte quantity female 77.0 days-91.0 days 13 8.38 x 10E6 cells/ul 0.09 0.31 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36577 401
WKY/NCrl blood pH control condition PhysGen Respiratory data blood acidity-alkalinity balance trait female 82.0 days-99.0 days 12 7.48 null 0.01 0.02 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19324 381
WKY/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 16 155.33 breaths/min 4.75 19.01 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18205 381
WKY/NCrl respiration rate controlled air carbon dioxide content (7 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 194.39 breaths/min 6.6 22.87 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20182 381
WKY/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 8 109.01 mmHg 7.59 21.47 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49272 461
WKY/NCrl left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 106.02 mmHg 9.92 31.37 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49280 461
WKY/NCrl percent change in left ventricular systolic blood pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 63.01 % 8.38 25.15 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49651 461
WKY/NCrl heart weight to body weight ratio control condition PhysGen Cardiac data heart mass male 49.0 days-63.0 days 10 5.31 g/kg 0.24 0.77 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49665 461
WKY/NCrl heart left ventricle infarction weight to total heart left ventricle weight ratio controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 3 hours) PhysGen Cardiac data heart left ventricle integrity trait male 49.0 days-63.0 days 10 9.03 % 2.96 9.36 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49854 461
WKY/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 9 237.54 beats/min 7.97 23.9 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49970 461
WKY/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 205.68 beats/min 16.08 50.83 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49978 461
WKY/NCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount male 77.0 days-91.0 days 8 5.83 mmol/l 0.27 0.76 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39092 401
WKY/NCrl blood neutrophil count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data neutrophil quantity male 77.0 days-91.0 days 8 0.98 x 1000 cells/ul 0.16 0.46 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42366 401
WKY/NCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 9 1.93 g/dl 0.06 0.17 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39219 401
WKY/NCrl serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 10 143.1 mmol/l 0.67 2.13 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39337 401
WKY/NCrl serum albumin level control condition (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 13 3.83 g/dl 0.06 0.21 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39354 401
WKY/NCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount male 77.0 days-91.0 days 10 8.6 mg/dl 0.13 0.4 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42520 401
WKY/NCrl total white blood cell count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 8 3.91 x 1000 cells/ul 0.79 2.25 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39489 401
WKY/NCrl plasma creatinine level control condition (for 14 days) PhysGen Biochemistry data blood creatinine amount female 77.0 days-91.0 days 14 0.22 mg/dl 0.02 0.08 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39558 401
WKY/NCrl total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity female 77.0 days-91.0 days 13 3.82 x 1000 cells/ul 0.25 0.89 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42860 401
WKY/NCrl serum bicarbonate level control condition (for 14 days) PhysGen Biochemistry data blood bicarbonate amount male 77.0 days-91.0 days 10 26.5 mmol/l 1.11 3.5 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 43068 401
WKY/NCrl percent change in respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 20 125.38 % 4.3 19.23 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54523 381
WKY/NCrl serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 10 1.68 g/dl 0.05 0.15 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39976 401
WKY/NCrl serum potassium level control condition (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 14 3.82 mmol/l 0.1 0.38 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40652 401
WKY/NCrl serum total cholesterol level control condition (for 14 days) PhysGen Biochemistry data blood cholesterol amount male 77.0 days-91.0 days 10 102.1 mg/dl 2.8 8.85 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37905 401
WKY/NCrl serum chloride level control condition (for 14 days) PhysGen Biochemistry data blood chloride amount male 77.0 days-91.0 days 10 102.0 mmol/l 0.75 2.36 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41105 401
WKY/NCrl serum albumin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood albumin amount female 77.0 days-91.0 days 9 3.76 g/dl 0.06 0.19 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41138 401
WKY/NCrl serum alkaline phosphatase activity level control condition (for 14 days) PhysGen Biochemistry data blood alkaline phosphatase amount male 77.0 days-91.0 days 10 296.8 U/l 9.73 30.77 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38170 401
WKY/NCrl serum chloride level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood chloride amount female 77.0 days-91.0 days 9 104.33 mmol/l 0.6 1.8 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38187 401
WKY/NCrl serum sodium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood sodium amount male 77.0 days-91.0 days 10 138.8 mmol/l 0.99 3.12 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38236 401
WKY/NCrl blood eosinophil count control condition (for 14 days) PhysGen Biochemistry data eosinophil quantity female 77.0 days-91.0 days 13 0.01 x 1000 cells/ul 0.01 0.02 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38351 401
WKY/NCrl serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount male 77.0 days-91.0 days 10 67.9 U/l 5.89 18.63 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38613 401
WKY/NCrl percent change in left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 post-ischemic value/pre-ischemic value x 100% 39.1 % 7.86 23.58 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47520 461
WKY/NCrl percent change in heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 106.57 % 12.52 39.6 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47540 461
WKY/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 9 147.44 mmHg 6.89 20.66 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47664 461
WKY/NCrl heart rate controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 14 350.04 beats/min 18.22 68.19 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16121 381
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 -8.53 null 0.12 0.42 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55351 522
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 12 54.25 % 6.09 21.08 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55382 522
WKY/NCrl methylene blue to FAPGG metabolism-surface area product ratio methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 0.25 null 0.03 0.09 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57733 526
WKY/NCrl partial pressure of blood carbon dioxide (Pco2) controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 11 27.25 mmHg 0.42 1.4 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16370 381
WKY/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 9 0.05 mmHg-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58082 526
WKY/NCrl maximum contractile force per wet weight of aorta potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 20 1.61 g/mg 0.06 0.27 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55864 522
WKY/NCrl heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 9 0.27 null 0.02 0.05 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58440 526
WKY/NCrl heart right ventricle weight to left ventricle weight ratio control condition (for 14 days) PhysGen Lung data heart right ventricle mass female 77.0 days-91.0 days 19 0.23 null 0.01 0.05 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58447 526
WKY/NCrl methylene blue to FAPGG metabolism-surface area product ratio controlled air oxygen content (12 %) (for 14 days) then methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 0.34 null 0.01 0.04 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58572 526
WKY/NCrl hematocrit controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data erythrocyte quantity female 77.0 days-91.0 days 8 59.44 % 1.32 3.73 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58589 526
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 16.1 % 4.08 12.89 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55004 522
WKY/NCrl heart right ventricle weight to left ventricle weight ratio controlled air oxygen content (12 %) (for 14 days) PhysGen Lung data heart right ventricle mass male 77.0 days-91.0 days 10 0.51 null 0.03 0.11 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59966 526
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 13 73.77 % 2.67 9.63 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56703 522
WKY/NCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 15 0.49 E-7mole 0.13 0.52 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56796 522
WKY/NCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 20 -7.43 null 0.07 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56822 522
WKY/NCrl FAPGG metabolism-surface area product controlled air oxygen content (12 %) (for 14 days) then FAPGG (0.6 mmol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 9 37.66 ml/min/kg 4.72 14.16 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 60135 526
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 9 99.33 % 0.37 1.12 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56858 522
WKY/NCrl maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 10 1.52 g/mg 0.11 0.34 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56868 522
WKY/NCrl concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50) phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait female 70.0 days-84.0 days 20 0.04 umol/l 0.01 0.02 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57004 522
WKY/NCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 8 -10.64 mmHg 1.03 2.9 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17460 381
WKY/NCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 134.58 mmHg 5.12 15.36 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46047 461
WKY/NCrl arterial blood flow rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 11.15 ml/min/g 0.55 1.75 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46158 461
WKY/NCrl percent change in left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 6 post-ischemic value/pre-ischemic value x 100% 64.46 % 4.7 11.51 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46162 461
WKY/NCrl arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 9.07 ml/min/g 0.56 1.76 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46182 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 10 6.98 IU/g 0.65 2.04 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47174 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart lactate dehydrogenase activity female 49.0 days-63.0 days 10 7.57 IU/g 0.74 2.33 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47179 461
WKY/NCrl heart wet weight control condition PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 0.87 g 0.02 0.08 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48149 461
WKY/NCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 218.78 beats/min 13.14 41.55 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48170 461
WKY/NCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 241.4 beats/min 13.83 43.74 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48178 461
WKY/NCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 6 151.67 mmHg 4.98 12.2 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45014 461
WKY/NCrl left ventricular systolic blood pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 9 140.13 mmHg 5.22 15.66 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45022 461
WKY/NCrl percent change in left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 6 post-ischemic value/pre-ischemic value x 100% 32.08 % 5.11 12.52 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45040 461
WKY/NCrl time to peak heart contraction controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 1109.14 s 63.76 201.61 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45072 461
WKY/NCrl left ventricular developed pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart left ventricular blood pressure trait male 49.0 days-63.0 days 10 44.9 mmHg 5.64 17.84 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47391 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 6 0.38 IU/g 0.12 0.3 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48377 461
WKY/NCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 10 227.2 beats/min 20.62 65.2 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45352 461
WKY/NCrl heart rate controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 199.14 beats/min 8.9 28.14 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45360 461
WKY/NCrl diastolic blood pressure controlled exposure to ambient light (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 112.0 days 7 88.7 mmHg 0.83 2.2 vascular indwelling catheter method left common carotid artery 0.0 daytime (7 AM - 7 PM) 70083 1281
WKY/NCrl diastolic blood pressure controlled sodium content diet (8 %) (for 14 days) then controlled exposure to darkness (for 12 hours) Iwai N, et al., Circulation 1999 Nov 2;100(18):1923-9. arterial blood pressure trait male 126.0 days 7 93.9 mmHg 1.29 3.4 vascular indwelling catheter method left common carotid artery 0.0 nighttime (7 PM - 7 AM) 70088 1281
WKY/NCrl serum fructosamine level salidroside (40 mg/kg) (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood fructosamine amount male 175.0 days 6 152.0 umol/l 2.0 4.9 serum fructosamine analysis 0.0 103503 2827
WKY/NCrl blood glucose level salidroside (40 mg/kg) (for 28 days) then fasting (for 16 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 168.0 days 6 103.0 mg/dl 3.0 7.35 blood glucose test strip read by electrochemical glucometer 0.0 103511 2827
WKY/NCrl systolic blood pressure control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133.0 days-140.0 days 6 121.0 mmHg 3.0 7.35 intra-aortic abdominal radiotelemetry measured 12 hr/day for 1 week daytime measurement 103522 2827
WKY/NCrl systolic blood pressure salidroside (40 mg/kg) (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 168.0 days 6 123.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry measured 12 hr/night for 4 weeks nighttime measurement 103535 2827
WKY/NCrl diastolic blood pressure control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133.0 days-140.0 days 6 87.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry 0.0 measured 12 hr/night for 1 week nighttime measurement 103547 2827
WKY/NCrl heart rate salidroside (40 mg/kg) (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168.0 days 6 334.0 beats/min 3.0 7.35 intra-aortic abdominal radiotelemetry measured 12 hr/night for 4 weeks nighttime measurement 103567 2827
WKY/NCrl number of spontaneous locomotor movements per unit time control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. locomotor behavior trait male 140.0 days 6 1.0 /min 0.1 0.24 intra-aortic abdominal radiotelemetry 0.0 number of spontaneous locomotor movements per unit time (CMO:0003644) 103571 2827
WKY/NCrl number of spontaneous locomotor movements per unit time vehicle control condition (between 1 and 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. locomotor behavior trait male 168.0 days 6 0.9 /min 0.1 0.24 intra-aortic abdominal radiotelemetry measured 12 hr/day for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103574 2827
WKY/NCrl number of spontaneous locomotor movements per unit time salidroside (40 mg/kg) (between 1 and 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. locomotor behavior trait male 168.0 days 6 3.4 /min 0.3 0.73 intra-aortic abdominal radiotelemetry measured 12 hr/night for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103583 2827
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 -7.07 null 0.05 0.14 wire myography 103586 2827
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 -7.1 null 0.04 0.11 wire myography 103587 2827
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 89.88 % 2.56 6.77 wire myography 0.0 103590 2827
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 97.56 % 1.02 2.7 wire myography 0.0 103598 2827
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 -8.21 null 0.07 0.19 wire myography 0.0 103611 2827
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 90.13 % 1.55 4.1 wire myography 0.0 103615 2827
WKY/NCrl norepinephrine-induced blood vessel contractile force expressed as percent of force of contraction to KCL control condition Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. vasoconstriction trait male 84.0 days 10 105.7 % 11.0 34.79 wire myography 0.0 norepinephrine-induced blood vessel contractile force expressed as percent of force at baseline (CMO:0003676) 109377 3141
WKY/NCrl end-systolic volume standard condition (between 112 and 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. cardiac output trait male 189.0 days-210.0 days 0.25 ml 0.01 transthoracic echocardiography 0.0 standard rat chow 107128 3075
WKY/NCrl absolute change in mean arterial blood pressure artificial cerebrospinal fluid (200 nl) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. arterial blood pressure trait not specified  days 7 2.0 mmHg 1.0 2.65 vascular fluid filled catheter 0.0 110103 2685
WKY/NCrl absolute change in mean arterial blood pressure artificial cerebrospinal fluid (200 nl) then angiotensin II (90 ng) then candesartan (0.05 ug) (for 0.2 hours) then angiotensin II (90 ng) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. arterial blood pressure trait not specified  days 3 10.0 mmHg 3.0 5.2 vascular fluid filled catheter 0.0 110105 2685
WKY/NCrl absolute change in heart rate artificial cerebrospinal fluid (200 nl) then angiotensin II (90 ng) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. heart pumping trait not specified  days 7 29.0 beats/min 6.0 15.87 vascular fluid filled catheter 0.0 110108 2685
WKY/NCrl heart weight to body weight ratio control condition Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. heart mass male 84.0 days 10 2.65 g/kg 0.08 0.25 post excision weight measurement 0.0 109278 3141
WKY/NCrl systolic blood pressure control condition Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. arterial blood pressure trait male 84.0 days 10 139.0 mmHg 5.0 15.81 tail cuff plethysmography 0.0 109281 3141
WKY/NCrl urine albumin excretion rate control condition Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. urine albumin amount male 84.0 days 10 0.2 mg/d 0.1 0.32 enzyme linked immunosorbent assay 0.0 109284 3141
WKY/NCrl body weight standard condition (for 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. body mass male 203.0 days-224.0 days 10 409.0 g 7.0 22.14 body weighing method 0.0 standard rat chow 107108 3075
WKY/NCrl ratio of deaths related to left ventricular hypertrophy to total study population during a period of time standard condition (for 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. total life span male 203.0 days-224.0 days 20 0.0 % unspecified method 0.0 ratio of deaths related to left ventricular hypertrophy to total study population during a period of time (CMO:0003810) 107115 3075
WKY/NCrl body weight control condition (0 null) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 21.0 days 15 39.2 g 1.46 5.66 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140078 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 35 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 56.0 days 15 193.87 g 3.49 13.53 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140083 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 63 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 84.0 days 15 283.13 g 3.76 14.57 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140087 3292
WKY/NCrl total body water mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 21.0 days 15 10.89 % 0.32 1.24 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 140095 3292
WKY/NCrl total body fat-free mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 15 87.81 % 0.5 1.93 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 140096 3292
WKY/NCrl total body fat mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 70.0 days 15 10.13 % 0.36 1.41 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 140109 3292
WKY/NCrl both kidneys wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. kidney mass male 91.0 days 15 2.2 g 0.04 0.14 post excision weight measurement weight scale Total Kidneys Changed sex from M to male to standardize across records, 7-30-2024 140126 3292
WKY/NCrl calories absorbed to calorie intake ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait male 70.0 days 15 86.91 % 0.65 2.53 constant volume calorimetry Bomb calorimetry; 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food Digestive efficiency Changed sex from M to male to standardize across records, 7-30-2024 140121 3292
WKY/NCrl heart left ventricle weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. heart left ventricle mass male 91.0 days 15 0.79 g 0.02 0.06 post excision weight measurement weight scale Left ventricle of the heart Changed sex from M to male to standardize across records, 7-30-2024 140125 3292
WKY/NCrl renal fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. renal fat pad mass male 91.0 days 15 4.94 g 0.2 0.79 post excision weight measurement weight scale PWAT Changed sex from M to male to standardize across records, 7-30-2024 140128 3292
WKY/NCrl inguinal fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. inguinal fat pad mass male 91.0 days 15 4.88 g 0.18 0.7 post excision weight measurement weight scale IWAT Changed sex from M to male to standardize across records, 7-30-2024 140129 3292
WKY/NCrl pituitary gland wet weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. pituitary gland mass male 91.0 days 14 0.01 g 0.0 0.0 post excision weight measurement weight scale Pituitary gland Changed sex from M to male to standardize across records, 7-30-2024 140134 3292
WKY/NCrl interscapular fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. interscapular fat pad mass male 91.0 days 12 335.64 mg 11.13 38.57 post excision weight measurement weight scale BAT Changed sex from M to male to standardize across records, 7-30-2024 140130 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 14 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 35.0 days 10 86.2 g 2.12 6.71 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139885 3292
WKY/NCrl total body fat-free mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 54.05 g 2.34 7.41 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 139905 3292
WKY/NCrl total body water mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 28.0 days 10 7.22 % 0.15 0.48 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 139908 3292
WKY/NCrl total body lean mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 63.79 % 0.44 1.39 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 139907 3292
WKY/NCrl total body lean mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 70.0 days 10 110.68 g 1.51 4.79 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 139911 3292
WKY/NCrl total body fat mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 70.0 days 10 18.54 g 0.88 2.78 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 139910 3292
WKY/NCrl total body fat-free mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 82.11 % 0.35 1.1 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 139909 3292
WKY/NCrl total body fat mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 70.0 days 10 10.75 % 0.45 1.43 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 139914 3292
WKY/NCrl total body water mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 70.0 days 10 7.47 % 0.09 0.29 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 139916 3292
WKY/NCrl total body fat-free mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 70.0 days 10 89.25 % 0.45 1.43 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 139917 3292
WKY/NCrl body weight gain to calories absorbed ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. food conversion trait female 70.0 days 10 0.24 g/kcal 0.01 0.03 constant volume calorimetry "Body weight gain, bomb calorimetry"; Bomb calorimetry data from 4 and 10 weeks were combined with body weight gain data; body weight gained per calorie absorbed Energy efficiency Changed sex from F to female to standardize across records, 7-30-2024 139927 3292
WKY/NCrl liver wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. liver mass female 91.0 days 10 6.99 g 0.15 0.49 post excision weight measurement weight scale Liver Changed sex from F to female to standardize across records, 7-30-2024 139929 3292
WKY/NCrl both kidneys wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. kidney mass female 91.0 days 10 1.41 g 0.03 0.1 post excision weight measurement weight scale Total Kidneys Changed sex from F to female to standardize across records, 7-30-2024 139931 3292
WKY/NCrl pituitary gland wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. pituitary gland mass female 91.0 days 10 0.01 g 0.0 0.0 post excision weight measurement weight scale Pituitary gland Changed sex from F to female to standardize across records, 7-30-2024 139939 3292
WKY/NCrl thymus wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. thymus mass female 91.0 days 2 244.9 mg 8.2 11.6 post excision weight measurement weight scale Thymus gland Changed sex from F to female to standardize across records, 7-30-2024 139940 3292
WKY/NCrl body mass index (BMI) controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 91.0 days 10 0.49 g/cm2 0.01 0.02 body weighing method "weight scale, tape measure" Body Mass Index (BMI) Changed sex from F to female to standardize across records, 7-30-2024 139946 3292
WKY/NCrl body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 7.0 days 10 9.88 g 0.44 1.39 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139947 3292
WKY/NCrl body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 14.0 days 10 22.97 g 0.68 2.14 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139948 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 63 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 84.0 days 10 193.3 g 2.53 8.01 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139958 3292
WKY/NCrl total body lean mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 25.84 g 0.75 2.36 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 139961 3292
WKY/NCrl total body fat mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 21.0 days 10 13.98 % 0.61 1.92 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 139964 3292
WKY/NCrl total body water mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 28.0 days 10 4.45 g 0.22 0.69 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 139970 3292
WKY/NCrl total body fat mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 28.0 days 10 18.77 % 0.53 1.66 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 139972 3292
WKY/NCrl total body fat mass controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 70.0 days 10 18.85 g 0.96 3.05 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 139976 3292
WKY/NCrl total body water mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 28.0 days 10 6.87 % 0.07 0.22 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 139974 3292
WKY/NCrl average daily food intake weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. eating behavior trait female 28.0 days 9 10.57 g/d 0.41 1.23 metabolic cage food consumption measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour food intake Changed sex from F to female to standardize across records, 7-30-2024 139984 3292
WKY/NCrl total body fat mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 70.0 days 9 11.26 % 0.2 0.61 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 139980 3292
WKY/NCrl defecation rate by mass controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait female 28.0 days 10 1.74 g/d 0.1 0.32 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from F to female to standardize across records, 7-30-2024 139986 3292
WKY/NCrl calories absorbed to calorie intake ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait female 28.0 days 10 88.3 % 0.59 1.88 constant volume calorimetry Bomb calorimetry; 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food Digestive efficiency Changed sex from F to female to standardize across records, 7-30-2024 139987 3292
WKY/NCrl body weight gain to calories absorbed ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. food conversion trait female 70.0 days 9 0.24 g/kcal 0.01 0.02 constant volume calorimetry "Body weight gain, bomb calorimetry"; Bomb calorimetry data from 4 and 10 weeks were combined with body weight gain data; body weight gained per calorie absorbed Energy efficiency Changed sex from F to female to standardize across records, 7-30-2024 139993 3292
WKY/NCrl renal fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. renal fat pad mass female 91.0 days 10 3.44 g 0.12 0.38 post excision weight measurement weight scale PWAT Changed sex from F to female to standardize across records, 7-30-2024 139999 3292
WKY/NCrl inguinal fat pad weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. inguinal fat pad mass female 91.0 days 10 2.8 g 0.1 0.33 post excision weight measurement weight scale IWAT Changed sex from F to female to standardize across records, 7-30-2024 140000 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 28.0 days 15 63.93 g 2.46 9.53 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140013 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 21 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 42.0 days 15 125.0 g 2.48 9.62 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140015 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 42 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 63.0 days 14 221.79 g 3.11 11.62 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140018 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 35 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 56.0 days 15 193.73 g 2.84 11.0 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140017 3292
WKY/NCrl total body fat mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 21.0 days 15 12.03 % 0.56 2.17 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 140027 3292
WKY/NCrl total body fat-free mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 15 87.97 % 0.56 2.16 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 140030 3292
WKY/NCrl total body fat mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 28.0 days 15 17.74 % 0.33 1.27 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 140035 3292
WKY/NCrl total body fat-free mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 28.0 days 15 82.26 % 0.33 1.27 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 140038 3292
WKY/NCrl calculated water drink intake volume controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait male 28.0 days 15 15.87 mL/d 0.63 2.45 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from M to male to standardize across records, 7-30-2024 140048 3292
WKY/NCrl calories absorbed to calorie intake ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait male 28.0 days 15 88.53 % 0.41 1.6 constant volume calorimetry Bomb calorimetry; 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food Digestive efficiency Changed sex from M to male to standardize across records, 7-30-2024 140050 3292
WKY/NCrl blood glucose level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) then fasting (for 16 hours) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood glucose amount male 91.0 days 12 72.58 mg/dl 1.27 4.4 blood glucose test strip read by electrochemical glucometer "overnight fast, saphenous vien "; "animals were fasted overnight (~16 hours), hind left leg shaved, pricked saphenous vein using a lancet, used glucometer to measure blood glucose" Fasted blood glucose Changed sex from M to male to standardize across records, 7-30-2024 140057 3292
WKY/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 12 28.11 mmHg 0.68 2.37 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15623 381
WKY/NCrl mean arterial blood pressure control condition PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 14 121.44 mmHg 5.03 18.81 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15792 381
WKY/NCrl partial pressure of blood carbon dioxide (Pco2) control condition PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 11 32.46 mmHg 0.78 2.59 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 15359 381
WKY/NCrl percent change in ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 %change=VE during 2-3 min hypercapnia/control during standard conditions 247.7 % 17.91 59.41 stop flow air displacement plethysmography 0 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14397 381
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -25.07 beats/min 31.67 77.58 vascular fluid filled catheter 51682 481
WKY/NCrl heart rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 336.79 beats/min 11.9 35.71 vascular fluid filled catheter 51780 481
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 115.67 mmHg 1.6 4.24 vascular fluid filled catheter 51880 481
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 119.39 mmHg 2.87 7.59 vascular fluid filled catheter 51906 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 9 -14.79 mmHg 5.52 16.56 vascular fluid filled catheter 51914 481
WKY/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data renin activity male 87.0 days-120.0 days 8 6.96 ng/ml/h 0.75 2.12 radioimmunoassay 51957 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 4.17 mmHg 3.77 9.97 vascular fluid filled catheter 51992 481
WKY/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data glomerular filtration trait female 87.0 days-120.0 days 5 0.94 ml/min 0.17 0.39 urine creatinine analysis 52030 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 7 -61.7 beats/min 18.98 50.22 vascular fluid filled catheter 50515 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait female 87.0 days-120.0 days 6 -53.6 beats/min 20.05 49.12 vascular fluid filled catheter 50553 481
WKY/NCrl creatinine clearance controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data glomerular filtration trait male 87.0 days-120.0 days 9 1.54 ml/min 0.09 0.27 urine creatinine analysis 50572 481
WKY/NCrl plasma renin activity level controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data renin activity female 87.0 days-120.0 days 6 3.33 ng/ml/h 1.41 3.46 radioimmunoassay 50715 481
WKY/NCrl mean arterial blood pressure controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) then controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 113.96 mmHg 3.81 9.34 vascular fluid filled catheter 50839 481
WKY/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) PhysGen Renal A data urine sodium amount female 87.0 days-120.0 days 8 10.64 mEq/d 1.12 3.17 flame atomic emission spectrometry 50872 481
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -47.6 beats/min 15.76 47.28 vascular fluid filled catheter 51040 481
WKY/NCrl percent change in tidal volume controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 20 100.69 % 3.04 13.61 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54195 381
WKY/NCrl absolute change in heart rate controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (for 0.2 hours) then norepinephrine (0.2 ng/kg/min) (for 0.2 hours) then norepinephrine (0.5 ng/kg/min) (for 0.2 hours) then norepinephrine (1 ng/kg/min) (for 0.2 hours) PhysGen Renal A data heart pumping trait male 87.0 days-120.0 days 9 -24.26 beats/min 15.5 46.5 vascular fluid filled catheter 51411 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then norepinephrine (0.1 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 7 1.15 mmHg 3.77 9.97 vascular fluid filled catheter 51625 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (for 0.2 hours) then angiotensin (10 ng/kg/min) (for 0.2 hours) then angiotensin (25 ng/kg/min) (for 0.2 hours) then angiotensin (50 ng/kg/min) (for 0.2 hours) PhysGen Renal A data arterial blood pressure trait male 87.0 days-120.0 days 7 0.65 mmHg 3.15 8.34 vascular fluid filled catheter 50379 481
WKY/NCrl absolute change in mean arterial blood pressure controlled sodium content diet (4 %) (between 24 and 31 days) then angiotensin (5 ng/kg/min) (between 0.2 and 0.2 hours) PhysGen Renal A data arterial blood pressure trait female 87.0 days-120.0 days 6 11.66 mmHg 3.45 8.44 vascular fluid filled catheter 50408 481
WKY/NCrl urine sodium excretion rate controlled sodium content diet (4 %) (between 17 and 36 days) then furosemide (10 mg/kg) and controlled sodium content diet (0.4 %) (for 2 days) PhysGen Renal A data urine sodium amount male 87.0 days-120.0 days 9 1.07 mEq/d 0.08 0.24 flame atomic emission spectrometry 50436 481
WKY/NCrl mean arterial blood pressure controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data arterial blood pressure trait female 82.0 days-99.0 days 7 125.14 mmHg 6.06 16.03 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13456 381
WKY/NCrl body temperature controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 37.3 degrees C 0.19 0.67 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14180 381
WKY/NCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 12 -6.22 mmHg 0.76 2.64 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17195 381
WKY/NCrl respiration rate control condition PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 20 128.48 breaths/min 4.84 21.63 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17329 381
WKY/NCrl percent change in ventilation controlled sodium content diet (0 %) then controlled air oxygen content (12 %) (between 0.1 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 16 %change=VE during7-9 min hypoxia/control during standard conditions 147.72 % 9.81 39.24 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17332 381
WKY/NCrl partial pressure of blood oxygen resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood oxygen amount male 82.0 days-99.0 days 8 107.09 mmHg 2.54 7.17 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 13817 381
WKY/NCrl tidal volume controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 20 0.28 ml 0.01 0.06 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14015 381
WKY/NCrl partial pressure of blood oxygen control condition PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 12 95.34 mmHg 3.21 11.13 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14082 381
WKY/NCrl absolute change in heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 5 131.05 beats/min 11.64 26.03 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 14109 381
WKY/NCrl minute ventilation controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait female 82.0 days-99.0 days 20 44.59 ml/min 2.73 12.22 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19723 381
WKY/NCrl percent change in respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 151.11 % 7.96 26.39 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 53858 381
WKY/NCrl mean arterial blood pressure resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data arterial blood pressure trait male 82.0 days-99.0 days 6 129.58 mmHg 3.54 8.67 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20129 381
WKY/NCrl absolute change in partial pressure of blood oxygen controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood oxygen amount female 82.0 days-99.0 days 10 -39.28 mmHg 3.39 10.71 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 20693 381
WKY/NCrl minute ventilation controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data pulmonary ventilation trait male 82.0 days-99.0 days 11 84.66 ml/min 5.55 18.42 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19584 381
WKY/NCrl partial pressure of blood carbon dioxide (Pco2) resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount male 82.0 days-99.0 days 12 34.33 mmHg 0.49 1.69 automated blood gas analysis using a Bayer analyzer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 19682 381
WKY/NCrl urine total protein excretion rate anti-glomerular basement membrane antibody (500 ul) Kose H, et al., Exp Anim. 2009 Apr;58(2):193-8. total urine protein amount female 61.0 days 10 178.08 mg/d urine protein analysis 0.0 antibody injection 5 days 67607 307
WKY/NCrl body temperature control condition PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 12 37.54 degrees C 0.2 0.68 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17787 381
WKY/NCrl respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait male 82.0 days-99.0 days 11 197.77 breaths/min 7.22 23.96 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17954 381
WKY/NCrl respiration rate controlled air carbon dioxide content (7 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 12 191.02 breaths/min 6.21 21.5 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17962 381
WKY/NCrl heart rate controlled air carbon dioxide content (7 %) (for 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 10 341.65 beats/min 14.23 45.01 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18078 381
WKY/NCrl blood pH controlled air oxygen content (12 %) (for 0.1 hours) PhysGen Respiratory data blood acidity-alkalinity balance trait male 82.0 days-99.0 days 11 7.55 null 0.01 0.03 automated blood gas analysis using a Bayer analyzer Conversion period. Moms had mixed diet, Dyets and Teklad, for 3-4 weeks. Whatever Mom was fed, so were pups. Whatever pups were fed in the barrier, they continued with through the study. Possible maternal influence on pups estimated at 10 weeks 18089 381
WKY/NCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 5 520.54 beats/min 3.35 7.49 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18792 381
WKY/NCrl heart rate resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 3 525.29 beats/min 2.07 3.58 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18797 381
WKY/NCrl body temperature resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (for 0.1 hours) PhysGen Respiratory data body temperature trait female 82.0 days-99.0 days 10 37.64 degrees C 0.15 0.47 digital rectal thermometry Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18807 381
WKY/NCrl serum total protein level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood total protein amount male 77.0 days-91.0 days 9 5.36 g/dl 0.09 0.28 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36261 401
WKY/NCrl mean corpuscular hemoglobin controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 9 18.8 pg 0.24 0.71 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 36361 401
WKY/NCrl serum urea nitrogen level control condition (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount male 77.0 days-91.0 days 10 16.3 mg/dl 0.88 2.79 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37282 401
WKY/NCrl serum total protein level control condition (for 14 days) PhysGen Biochemistry data blood total protein amount female 77.0 days-91.0 days 13 5.75 g/dl 0.09 0.31 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37419 401
WKY/NCrl serum aspartate aminotransferase activity level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood aspartate transaminase amount male 77.0 days-91.0 days 9 139.33 U/l 14.41 43.22 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37422 401
WKY/NCrl respiration rate controlled air oxygen content (12 %) (between 0 and 0.1 hours) PhysGen Respiratory data respiratory function trait female 82.0 days-99.0 days 20 158.6 breaths/min 5.09 22.75 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 18213 381
WKY/NCrl heart contraction pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait female 49.0 days-63.0 days 8 27.38 mmHg 4.12 11.65 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 49595 461
WKY/NCrl body weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data body mass male 49.0 days-63.0 days 9 146.7 g 3.9 11.8 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 50079 461
WKY/NCrl serum potassium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood potassium amount female 77.0 days-91.0 days 8 4.84 mmol/l 0.12 0.34 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39099 401
WKY/NCrl serum globulin level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood globulin amount male 77.0 days-91.0 days 10 1.81 g/dl 0.07 0.21 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39212 401
WKY/NCrl serum sodium level control condition (for 14 days) PhysGen Biochemistry data blood sodium amount female 77.0 days-91.0 days 13 144.23 mmol/l 0.94 3.39 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39344 401
WKY/NCrl serum calcium level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood calcium amount female 77.0 days-91.0 days 9 9.38 mg/dl 0.06 0.19 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42527 401
WKY/NCrl serum urea nitrogen level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood urea nitrogen amount female 77.0 days-91.0 days 9 19.11 mg/dl 0.82 2.47 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39518 401
WKY/NCrl blood hemoglobin level control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount male 77.0 days-91.0 days 10 14.27 g/dl 0.25 0.79 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42739 401
WKY/NCrl total white blood cell count control condition (for 14 days) PhysGen Biochemistry data leukocyte quantity male 77.0 days-91.0 days 10 4.54 x 1000 cells/ul 0.3 0.96 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 42853 401
WKY/NCrl serum globulin level control condition (for 14 days) PhysGen Biochemistry data blood globulin amount female 77.0 days-91.0 days 13 1.92 g/dl 0.04 0.15 standard blood chemistry panel replaced obsolete serum globulin level term, 1/19/2016 Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 39983 401
WKY/NCrl single kidney wet weight to body weight ratio anti-glomerular basement membrane antibody (500 ul) Kose H, et al., Exp Anim. 2009 Apr;58(2):193-8. kidney mass female 64.0 days 10 9.3 g/kg post excision weight measurement 0.0 antibody injection 8 days percentage of kidney weight/body weight 67688 307
WKY/NCrl calculated pulmonary vascular resistance normalized to body weight Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 13 0.09 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59044 526
WKY/NCrl blood monocyte count controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data monocyte quantity male 77.0 days-91.0 days 8 0.31 x 1000 cells/ul 0.14 0.4 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40689 401
WKY/NCrl plasma creatinine level controlled air oxygen content (12 %) (for 14 days) PhysGen Biochemistry data blood creatinine amount male 77.0 days-91.0 days 9 0.32 mg/dl 0.03 0.08 automated plasma creatinine analysis Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 40797 401
WKY/NCrl mean corpuscular volume control condition (for 14 days) PhysGen Biochemistry data erythrocyte size trait male 77.0 days-91.0 days 10 53.19 fl 0.28 0.87 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 37787 401
WKY/NCrl mean corpuscular hemoglobin control condition (for 14 days) PhysGen Biochemistry data blood hemoglobin amount female 77.0 days-91.0 days 13 17.1 pg 0.06 0.23 automated blood cell counting method Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 41279 401
WKY/NCrl serum alanine aminotransferase activity level control condition (for 14 days) PhysGen Biochemistry data blood alanine transaminase amount female 77.0 days-91.0 days 14 50.86 U/l 1.93 7.21 standard blood chemistry panel Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 38620 401
WKY/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait male 49.0 days-63.0 days 8 183.92 beats/min 12.88 36.42 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46499 461
WKY/NCrl heart rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 10 199.17 beats/min 23.44 74.12 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 46507 461
WKY/NCrl methylene blue metabolism-surface area product after auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) then sample resting period (for 0.1 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 7.91 ml/min/kg 1.06 2.79 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57449 526
WKY/NCrl logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 15 -7.84 null 0.08 0.31 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 55344 522
WKY/NCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 9 0.19 mmHg x min x kg x ml-1 0.0 0.01 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57681 526
WKY/NCrl calculated pulmonary vascular resistance normalized to body weight controlled air oxygen content (12 %) (for 14 days) then Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data pulmonary blood flow trait female 77.0 days-91.0 days 10 0.19 mmHg x min x kg x ml-1 0.01 0.03 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57688 526
WKY/NCrl fractional change in blood vessel diameter per unit change in intravascular pressure Kreb's solution perfusate (between 0.2 and 0.2 hours) PhysGen Lung data blood vessel distensibility trait male 77.0 days-91.0 days 8 0.08 mmHg-1 0.01 0.04 fluid-filled catheter with pressure transducer in isolated perfused lung Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57691 526
WKY/NCrl body weight control condition (for 14 days) PhysGen Lung data body mass female 77.0 days-91.0 days 19 167.9 g 3.0 13.0 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57708 526
WKY/NCrl heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait male 82.0 days-99.0 days 12 348.38 beats/min 12.01 41.61 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16427 381
WKY/NCrl heart rate resting on treadmill (between 0.1 and 0.1 hours) PhysGen Respiratory data heart pumping trait female 82.0 days-99.0 days 10 396.39 beats/min 7.63 24.12 vascular fluid filled catheter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 16435 381
WKY/NCrl methylene blue metabolism-surface area product without auto-oxidation methylene blue (10 umol/l) (between 0 and 0 hours) PhysGen Lung data pulmonary blood flow trait male 77.0 days-91.0 days 7 14.33 ml/min/kg 2.03 5.38 isolated perfused lung vascular effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 58304 526
WKY/NCrl body weight control condition (for 21 days) PhysGen Vascular data body mass female 70.0 days-84.0 days 20 177.6 g 3.0 13.6 whole body digital scale Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 54876 522
WKY/NCrl concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 15 0.18 10E-7mol/l 0.04 0.14 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56452 522
WKY/NCrl hematocrit control condition (for 14 days) PhysGen Lung data erythrocyte quantity male 77.0 days-91.0 days 9 44.52 % 0.7 2.1 microhematocrit tube assay with visual assessment Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 59850 526
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (0 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 68.0 % 3.09 10.71 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56688 522
WKY/NCrl logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50) controlled sodium content diet (4 %) (for 21 days) then phenylephrine (0-300 umol/l) and drug dose time series (for 1.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 14 -7.39 null 0.06 0.24 wire myography using a Digi-Med tissue force analysis system with force transducer EC50 value is moles/liter Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56734 522
WKY/NCrl concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50) phenylephrine (1 umol/l) (for 0.2 hours) then acetylcholine (0-30 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 18 0.29 E-7mole 0.05 0.21 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56803 522
WKY/NCrl hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) then controlled oxygen content physiological salt solution perfusate (95 %) (for 0.2 hours) then controlled oxygen content physiological salt solution perfusate (10 %) (for 0.3 hours) then controlled oxygen content physiological salt solution perfusate (5 %) (for 0.3 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 10 20.0 % 4.85 15.33 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56832 522
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel controlled sodium content diet (4 %) (for 21 days) then phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait male 70.0 days-84.0 days 14 99.29 % 0.27 0.99 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56851 522
WKY/NCrl maximum contractile force per wet weight of aorta controlled sodium content diet (4 %) (for 21 days) then potassium ion (80 mmol/l) (for 0.2 hours) and phenylephrine (10 umol/l) (for 0.2 hours) PhysGen Vascular data vasoconstriction trait male 70.0 days-84.0 days 15 1.28 g/mg 0.11 0.41 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 56861 522
WKY/NCrl sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel phenylephrine (1 umol/l) (for 0.2 hours) then sodium nitroprusside (0-3 umol/l) and drug dose time series (for 1 hours) PhysGen Vascular data vasodilation trait female 70.0 days-84.0 days 12 99.67 % 0.26 0.89 wire myography using a Digi-Med tissue force analysis system with force transducer Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 57123 522
WKY/NCrl absolute change in partial pressure of blood carbon dioxide resting on treadmill (for 0.1 hours) then walking on treadmill (0.8 m/min) (for 0.1 hours) then running on treadmill (1.6 m/min) (between 0.1 and 0.1 hours) PhysGen Respiratory data blood carbon dioxide amount female 82.0 days-99.0 days 3 -12.4 mmHg 3.18 5.51 stop flow air displacement plethysmography Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 17465 381
WKY/NCrl left ventricular developed pressure controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart left ventricular blood pressure trait female 49.0 days-63.0 days 10 143.0 mmHg 8.74 27.64 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47672 461
WKY/NCrl percent change in arterial blood flow rate controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) then controlled oxygen content Kreb's solution perfusate (for 0.7 hours) PhysGen Cardiac data arterial blood flow trait female 49.0 days-63.0 days 10 post-ischemic value/pre-ischemic value x 100% 63.79 % 5.5 17.4 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47890 461
WKY/NCrl time to onset of heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 8 955.43 s 64.85 183.43 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 48118 461
WKY/NCrl heart wet weight controlled air oxygen content (12 %) (for 14 days) PhysGen Cardiac data heart mass female 49.0 days-63.0 days 10 1.0 g 0.06 0.18 digital scale post excision weight measurement Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45036 461
WKY/NCrl time to peak heart contraction controlled air oxygen content (12 %) (for 14 days) then controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart pumping trait female 49.0 days-63.0 days 8 1179.4 s 75.27 212.89 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45109 461
WKY/NCrl heart contraction pressure controlled oxygen content Kreb's solution perfusate (for 0.5 hours) then perfusate suspended (for 0.4 hours) PhysGen Cardiac data heart muscle contractility trait male 49.0 days-63.0 days 9 40.56 mmHg 5.02 15.07 balloon tipped catheter with pressure transducer in isolated perfused heart Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 47379 461
WKY/NCrl heart effluent lactate dehydrogenase activity level normalized to heart weight controlled oxygen content Kreb's solution perfusate (for 0.5 hours) PhysGen Cardiac data heart lactate dehydrogenase activity male 49.0 days-63.0 days 9 0.29 IU/g 0.05 0.15 isolated perfused heart effluent collection Moms were fed vendors standard diet, pups were fed Teklad upon arrival at MCW. For rats received from CRL and Harlan 45230 461
WKY/NCrl blood glucose level salidroside (40 mg/kg) (for 28 days) then fasting (for 16 hours) then glucose (2 g/kg) (for 2 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 168.0 days 6 121.0 mg/dl 2.0 4.9 oral glucose tolerance test 0.0 103519 2827
WKY/NCrl body weight vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. body mass male 168.0 days 6 463.0 g 7.0 17.15 body weighing method 0.0 103490 2827
WKY/NCrl blood glucose level vehicle control condition (for 28 days) then fasting (for 16 hours) then glucose (2 g/kg) (for 2 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. blood glucose amount male 168.0 days 6 125.0 mg/dl 3.0 7.35 oral glucose tolerance test 0.0 103518 2827
WKY/NCrl diastolic blood pressure control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133.0 days-140.0 days 6 82.0 mmHg 2.0 4.9 intra-aortic abdominal radiotelemetry 0.0 measured 12 hr/day for 1 week daytime measurement 103539 2827
WKY/NCrl diastolic blood pressure control condition and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. arterial blood pressure trait male 133.0 days-140.0 days 6 89.0 mmHg 4.0 9.8 intra-aortic abdominal radiotelemetry 0.0 measured 12 hr/night for 1 week nighttime measurement 103546 2827
WKY/NCrl heart rate control condition and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 130.0 days-140.0 days 6 280.0 beats/min 3.0 7.35 intra-aortic abdominal radiotelemetry 0.0 measured 12 hr/day for 1 week daytime measurement 103555 2827
WKY/NCrl heart rate salidroside (40 mg/kg) (for 28 days) and light phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168.0 days 6 284.0 beats/min 4.0 9.8 intra-aortic abdominal radiotelemetry measured 12 hr/day for 4 weeks daytime measurement 103559 2827
WKY/NCrl heart rate vehicle control condition (for 28 days) and dark phase of controlled light/dark cycle (for 12 hours) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. heart pumping trait male 168.0 days 6 344.0 beats/min 5.0 12.25 intra-aortic abdominal radiotelemetry measured 12 hr/night for 4 weeks nighttime measurement 103566 2827
WKY/NCrl number of spontaneous locomotor movements per unit time vehicle control condition (between 1 and 28 days) and dark phase of controlled light/dark cycle Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. locomotor behavior trait male 168.0 days 6 2.8 /min 0.3 0.73 intra-aortic abdominal radiotelemetry measured 12 hr/night for 4 weeks number of spontaneous locomotor movements per unit time (CMO:0003644) 103582 2827
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 -7.6 null 0.05 0.13 wire myography 0.0 103602 2827
WKY/NCrl logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50) salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 -7.72 null 0.03 0.08 wire myography 0.0 103603 2827
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel vehicle control condition (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 99.75 % 2.32 6.14 wire myography 0.0 103606 2827
WKY/NCrl acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel salidroside (40 mg/kg) (for 28 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. vasodilation trait male 168.0 days 7 96.2 % 1.31 3.47 wire myography 0.0 103607 2827
WKY/NCrl aorta wall phosphorylated eNOS level to total eNOS level ratio salidroside (40 mg/kg) (for 35 days) Alameddine A, et al., J Physiol Pharmacol. 2015 Apr;66(2):249-57. artery molecular composition trait male 175.0 days 7 1.3 null 0.27 0.71 western blot assay 0.0 103619 2827
WKY/NCrl heart rate standard condition (between 112 and 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. heart pumping trait male 189.0 days-210.0 days 349.0 beats/min 4.0 transthoracic echocardiography 0.0 standard rat chow 107132 3075
WKY/NCrl interscapular fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. interscapular fat pad mass male 91.0 days 12 355.61 mg 19.2 66.52 post excision weight measurement weight scale BAT Changed sex from M to male to standardize across records, 7-30-2024 140064 3292
WKY/NCrl thymus wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. thymus mass male 91.0 days 6 253.37 mg 7.91 19.38 post excision weight measurement weight scale Thymus gland Changed sex from M to male to standardize across records, 7-30-2024 140069 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 28.0 days 15 63.67 g 2.46 9.54 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140079 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 14 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 35.0 days 15 92.87 g 2.95 11.43 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140080 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 42 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 63.0 days 14 223.57 g 3.4 12.71 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140084 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 70.0 days 15 243.33 g 3.46 13.4 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140085 3292
WKY/NCrl total body fat-free mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 21.0 days 15 34.33 g 1.11 4.29 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 140092 3292
WKY/NCrl total body water mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 28.0 days 15 4.82 g 0.18 0.69 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 140099 3292
WKY/NCrl total body fat mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 28.0 days 15 17.27 % 0.3 1.16 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 140101 3292
WKY/NCrl total body water mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount male 28.0 days 15 7.23 % 0.11 0.44 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from M to male to standardize across records, 7-30-2024 140103 3292
WKY/NCrl total body lean mass controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 15 162.61 g 1.97 7.62 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 140106 3292
WKY/NCrl total body fat-free mass controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 15 221.75 g 2.76 10.7 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 140108 3292
WKY/NCrl total body fat-free mass to total body mass ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 15 89.87 % 0.36 1.41 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 140112 3292
WKY/NCrl calculated water drink intake volume controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait male 28.0 days 15 17.0 mL/d 1.02 3.96 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from M to male to standardize across records, 7-30-2024 140114 3292
WKY/NCrl calories absorbed to calorie intake ratio controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait male 28.0 days 15 88.66 % 0.23 0.91 constant volume calorimetry Bomb calorimetry; 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food Digestive efficiency Changed sex from M to male to standardize across records, 7-30-2024 140116 3292
WKY/NCrl blood glucose level controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) then fasting (for 16 hours) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood glucose amount male 91.0 days 15 69.13 mg/dl 1.44 5.59 blood glucose test strip read by electrochemical glucometer "overnight fast, saphenous vien "; "animals were fasted overnight (~16 hours), hind left leg shaved, pricked saphenous vein using a lancet, used glucometer to measure blood glucose" Fasted blood glucose Changed sex from M to male to standardize across records, 7-30-2024 140123 3292
WKY/NCrl absolute change in mean arterial blood pressure artificial cerebrospinal fluid (200 nl) then angiotensin II (90 ng) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. arterial blood pressure trait not specified  days 7 16.0 mmHg 2.0 5.29 vascular fluid filled catheter 0.0 110104 2685
WKY/NCrl body weight control condition Steireif C, etal., J Hypertens. 2013 Nov;31(11):2203-12; discussion 2212. doi: 10.1097/HJH.0b013e3283642384. body mass male 84.0 days 10 282.4 g 4.9 15.5 body weighing method 0.0 109272 3141
WKY/NCrl absolute change in heart rate artificial cerebrospinal fluid (200 nl) then angiotensin II (90 ng) then candesartan (0.5 ug) (for 0.2 hours) then angiotensin II (90 ng) Gabor A and Leenen FH, Brain Res. 2012 Apr 4;1447:28-37. doi: 10.1016/j.brainres.2012.01.060. Epub 2012 Feb 1. heart pumping trait not specified  days 4 11.0 beats/min 7.0 14.0 vascular fluid filled catheter 0.0 110137 2685
WKY/NCrl systolic blood pressure standard condition (for 126 days) Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. arterial blood pressure trait male 203.0 days-224.0 days 10 179.0 mmHg 3.0 9.49 tail cuff plethysmography tail 0.0 standard rat chow 107098 3075
WKY/NCrl end-diastolic volume standard condition Barone FC, etal., Pharmacology. 2007;80(2-3):166-76. doi: 10.1159/000103384. Epub 2007 Jun 4. cardiac output trait male 189.0 days-210.0 days 0.85 ml 0.02 transthoracic echocardiography 0.0 standard rat chow 107124 3075
WKY/NCrl body weight control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 14.0 days 10 23.19 g 0.71 2.26 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139882 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 28.0 days 10 62.1 g 2.48 7.85 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139884 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 21 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 42.0 days 10 110.1 g 1.74 5.51 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139886 3292
WKY/NCrl total body water mass control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 21.0 days 10 4.03 g 0.11 0.35 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 139896 3292
WKY/NCrl total body fat-free mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 21.0 days 10 86.05 % 0.47 1.48 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from F to female to standardize across records, 7-30-2024 139901 3292
WKY/NCrl total body lean mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass female 28.0 days 10 41.93 g 1.68 5.3 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from F to female to standardize across records, 7-30-2024 139903 3292
WKY/NCrl total body fat mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 28.0 days 10 17.89 % 0.35 1.1 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 139906 3292
WKY/NCrl calories absorbed to calorie intake ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait female 28.0 days 10 88.29 % 0.63 2.0 constant volume calorimetry Bomb calorimetry; 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food Digestive efficiency Changed sex from F to female to standardize across records, 7-30-2024 139921 3292
WKY/NCrl calculated water drink intake volume controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait female 70.0 days 10 26.2 mL/d 1.56 4.94 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from F to female to standardize across records, 7-30-2024 139923 3292
WKY/NCrl timed urine mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. urination behavior trait female 70.0 days 10 14.15 g/d 1.79 5.65 metabolic cage urine mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour urine output Changed sex from F to female to standardize across records, 7-30-2024 139924 3292
WKY/NCrl defecation rate by mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait female 70.0 days 10 2.56 g/d 0.15 0.46 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from F to female to standardize across records, 7-30-2024 139925 3292
WKY/NCrl renal fat pad weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. renal fat pad mass female 91.0 days 10 3.22 g 0.17 0.53 post excision weight measurement weight scale PWAT Changed sex from F to female to standardize across records, 7-30-2024 139933 3292
WKY/NCrl thyroid gland wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. thyroid gland mass female 91.0 days 10 9.95 mg 0.19 0.61 post excision weight measurement weight scale Thyroid gland Changed sex from F to female to standardize across records, 7-30-2024 139938 3292
WKY/NCrl serum triiodothyronine level controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. blood triiodothyronine amount female 91.0 days 8 133.49 µg/dL 2.64 7.48 radioimmunoassay RIA; RRID:AB_2940789 Serum total T3 Changed sex from F to female to standardize across records, 7-30-2024 139942 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 35 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 56.0 days 10 147.5 g 2.22 7.03 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139954 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 56 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 77.0 days 10 183.3 g 2.56 8.1 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139957 3292
WKY/NCrl body weight controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass female 91.0 days 10 200.6 g 2.68 8.47 body weighing method weight scale Body weight Changed sex from F to female to standardize across records, 7-30-2024 139959 3292
WKY/NCrl total body fat mass controlled bisphenol F content drinking water (1.125 mg/l) (for 7 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass female 28.0 days 10 12.28 g 0.85 2.69 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from F to female to standardize across records, 7-30-2024 139968 3292
WKY/NCrl total body water mass to total body mass ratio control condition Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 21.0 days 10 10.1 % 0.31 0.98 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 139966 3292
WKY/NCrl total body water mass controlled bisphenol F content drinking water (1.125 mg/l) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body water amount female 70.0 days 10 12.85 g 0.25 0.8 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fluid mass Changed sex from F to female to standardize across records, 7-30-2024 139978 3292
WKY/NCrl calculated water drink intake volume controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. drinking behavior trait female 28.0 days 9 15.89 mL/d 0.73 2.2 metabolic cage water drinking measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour fluid intake Changed sex from F to female to standardize across records, 7-30-2024 139985 3292
WKY/NCrl body length, nose to tail controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body length female 91.0 days 10 36.7 cm 0.23 0.72 body length measuring method tape measure Nose:tail body length Changed sex from F to female to standardize across records, 7-30-2024 140008 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 14 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 35.0 days 15 93.0 g 2.6 10.09 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140014 3292
WKY/NCrl body weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 91.0 days 15 300.67 g 3.27 12.68 body weighing method weight scale Body weight Changed sex from M to male to standardize across records, 7-30-2024 140022 3292
WKY/NCrl total body lean mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 15 161.47 g 2.03 7.87 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 140040 3292
WKY/NCrl total body fat-free mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 15 89.37 % 0.37 1.45 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat-free mass Changed sex from M to male to standardize across records, 7-30-2024 140046 3292
WKY/NCrl total body lean mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body lean mass male 70.0 days 15 65.36 % 0.35 1.37 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body lean mass Changed sex from M to male to standardize across records, 7-30-2024 140044 3292
WKY/NCrl total body fat mass to total body mass ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 49 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body fat mass male 70.0 days 15 10.63 % 0.37 1.45 time-domain nuclear magnetic resonance Time domain nuclear magentic resonance Total body fat mass Changed sex from M to male to standardize across records, 7-30-2024 140043 3292
WKY/NCrl defecation rate by mass controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. defecation behavior trait male 70.0 days 15 3.61 g/d 0.13 0.52 metabolic cage feces mass measurement method 86400.0 "Metabolic cages, 48 hours of acclimation, 24 hours data collection" 24-hour feces output Changed sex from M to male to standardize across records, 7-30-2024 140054 3292
WKY/NCrl calories absorbed to calorie intake ratio controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. nutrient absorption trait male 70.0 days 15 87.15 % 0.4 1.56 constant volume calorimetry Bomb calorimetry; 24-hour feces samples collected in metabolic cages were processed by bomb calorimetry; (the proportion of calories absorbed from consumed food Digestive efficiency Changed sex from M to male to standardize across records, 7-30-2024 140055 3292
WKY/NCrl liver wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. liver mass male 91.0 days 15 9.46 g 0.15 0.58 post excision weight measurement weight scale Liver Changed sex from M to male to standardize across records, 7-30-2024 140058 3292
WKY/NCrl both adrenal glands wet weight controlled ethanol content drinking water used as vehicle (0.1 %) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. adrenal gland mass male 91.0 days 13 48.45 mg 1.09 3.92 post excision weight measurement weight scale Adrenal glands Changed sex from M to male to standardize across records, 7-30-2024 140066 3292
WKY/NCrl body mass index (BMI) controlled bisphenol F content drinking water (1.125 mg/l) (for 70 days) Wagner VA, etal., Toxicol Sci. 2023 Jun 28;194(1):84-100. doi: 10.1093/toxsci/kfad046. body mass male 91.0 days 15 0.58 g/cm2 0.01 0.02 body weighing method "weight scale, tape measure" Body Mass Index (BMI) Changed sex from M to male to standardize across records, 7-30-2024 140138 3292