| GK/Slc |
body weight |
specific pathogen-free condition |
NBRP Body Weight data |
body mass |
male |
42.0 days
| 6 |
|
171.7 |
g |
1.96 |
4.8 |
whole body digital scale |
|
|
|
|
70811 |
21 |
| GK/Slc |
heart weight to body weight ratio |
specific pathogen-free condition |
NBRP Organ Weight data |
heart mass |
male |
70.0 days
| 6 |
|
3.48 |
g/kg |
0.1 |
0.25 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72228 |
41 |
| GK/Slc |
lung wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
lung mass |
male |
70.0 days
| 6 |
|
0.98 |
g |
0.03 |
0.07 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72229 |
41 |
| GK/Slc |
liver weight as percentage of body weight |
specific pathogen-free condition |
NBRP Organ Weight data |
liver mass |
male |
70.0 days
| 6 |
|
3.13 |
% |
0.13 |
0.32 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72232 |
41 |
| GK/Slc |
both adrenal glands wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
adrenal gland mass |
male |
70.0 days
| 6 |
|
36.3 |
mg |
2.53 |
6.2 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72235 |
41 |
| GK/Slc |
mean corpuscular hemoglobin |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood hemoglobin amount |
male |
70.0 days
| 6 |
|
18.6 |
pg |
0.12 |
0.3 |
automated cell/particle size/count analysis method |
|
|
Sysmex, F-800 type |
|
78370 |
1498 |
| GK/Slc |
white blood cell count |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
leukocyte quantity |
male |
70.0 days
| 6 |
|
6.1 |
x 1000 cells/ul |
0.33 |
0.8 |
automated cell/particle size/count analysis method |
|
|
Sysmex, F-800 type |
|
78372 |
1498 |
| GK/Slc |
activated partial thromboplastin time |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood coagulation trait |
male |
70.0 days
| 6 |
|
14.5 |
s |
0.57 |
1.4 |
automated coagulometer method |
|
|
Sysmex, CA-3000 type |
|
78375 |
1498 |
| GK/Slc |
plasma aspartate aminotransferase activity level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood aspartate transaminase amount |
male |
70.0 days
| 6 |
|
65.0 |
U/l |
5.72 |
14.0 |
automated plasma analysis |
|
|
PMID:15591307 |
|
78376 |
1498 |
| GK/Slc |
plasma alanine aminotransferase activity level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood alanine transaminase amount |
male |
70.0 days
| 6 |
|
44.0 |
U/l |
7.35 |
18.0 |
automated plasma analysis |
|
|
PMID:15591307 |
|
78377 |
1498 |
| GK/Slc |
plasma total protein level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood total protein amount |
male |
70.0 days
| 6 |
|
64.0 |
mg/ml |
0.41 |
1.0 |
automated plasma total protein analysis |
|
|
Hitachi, model 7170 |
|
78379 |
1498 |
| GK/Slc |
plasma total cholesterol level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood cholesterol amount |
male |
70.0 days
| 6 |
|
99.0 |
mg/dl |
2.04 |
5.0 |
automated plasma analysis |
|
|
PMID:15591307 |
|
78383 |
1498 |
| GK/Slc |
blood eosinophil count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
eosinophil quantity |
male |
70.0 days
| 6 |
|
1.0 |
% |
0.41 |
1.0 |
automated differential white blood cell count test |
|
|
May-Giemsa staining |
|
78396 |
1498 |
| GK/Slc |
non-specified leukocyte count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
leukocyte quantity |
male |
70.0 days
| 6 |
|
0.0 |
% |
0.0 |
0.0 |
automated differential white blood cell count test |
|
|
May-Giemsa staining |
unidentified differential wbc |
78401 |
1498 |
| GK/Slc |
body temperature |
specific pathogen-free condition |
NBRP Body Temperature data |
body temperature trait |
male |
56.0 days-70.0 days |
6 |
serial mean |
37.9 |
degrees C |
0.12 |
0.3 |
digital rectal thermometry |
|
|
|
|
75065 |
22 |
| GK/Slc |
blood high density lipoprotein cholesterol level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood HDL cholesterol amount |
male |
105.0 days
| |
|
9.0 |
mg/dl |
0.9 |
|
blood high-density lipoprotein-cholesterol measurement test |
0.0 |
|
|
n=4-6 |
102896 |
2781 |
| GK/Slc |
blood high density lipoprotein cholesterol level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood HDL cholesterol amount |
male |
105.0 days
| |
|
7.0 |
mg/dl |
0.7 |
|
blood high-density lipoprotein-cholesterol measurement test |
0.0 |
|
|
n=4-6 |
102897 |
2781 |
| GK/Slc |
blood urea nitrogen level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood urea nitrogen amount |
male |
105.0 days
| |
|
15.7 |
mg/dl |
1.2 |
|
blood urea nitrogen analysis |
0.0 |
|
|
n=4-6 |
102904 |
2781 |
| GK/Slc |
urine 3-hydroxybutyrate level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
urine ketone body amount |
male |
105.0 days
| |
|
1161.8 |
umol/l |
301.9 |
|
urine analysis |
0.0 |
|
|
n=4-6 |
102921 |
2781 |
| GK/Slc |
urine glucose level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
urine glucose amount |
male |
105.0 days
| |
|
588.3 |
mg/dl |
349.4 |
|
blood glucose test strip read by electrochemical glucometer |
0.0 |
|
|
n=4-6 |
102928 |
2781 |
| GK/Slc |
body weight |
specific pathogen-free condition |
NBRP Body Weight data |
body mass |
male |
35.0 days
| 6 |
|
112.9 |
g |
0.94 |
2.3 |
whole body digital scale |
|
|
|
|
70809 |
21 |
| GK/Slc |
brain wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
brain mass |
male |
70.0 days
| 6 |
|
1.87 |
g |
0.02 |
0.05 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72225 |
41 |
| GK/Slc |
brain weight to body weight ratio |
specific pathogen-free condition |
NBRP Organ Weight data |
brain mass |
male |
70.0 days
| 6 |
|
0.67 |
% |
0.02 |
0.04 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72226 |
41 |
| GK/Slc |
both kidneys wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
kidney mass |
male |
70.0 days
| 6 |
|
2.09 |
g |
0.06 |
0.15 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72233 |
41 |
| GK/Slc |
spleen wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
spleen mass |
male |
70.0 days
| 6 |
|
0.6 |
g |
0.02 |
0.04 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72237 |
41 |
| GK/Slc |
both testes wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
testis mass |
male |
70.0 days
| 6 |
|
2.55 |
g |
0.04 |
0.1 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72239 |
41 |
| GK/Slc |
red blood cell count |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
erythrocyte quantity |
male |
70.0 days
| 6 |
|
8.95 |
x 10E6 cells/ul |
0.16 |
0.38 |
automated cell/particle size/count analysis method |
|
|
Sysmex, F-800 type |
|
78366 |
1498 |
| GK/Slc |
hematocrit |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
erythrocyte quantity |
male |
70.0 days
| 6 |
|
55.0 |
% |
0.69 |
1.7 |
automated cell/particle size/count analysis method |
|
|
Sysmex, F-800 type |
|
78368 |
1498 |
| GK/Slc |
mean corpuscular volume |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
erythrocyte size trait |
male |
70.0 days
| 6 |
|
61.5 |
fl |
0.73 |
1.8 |
automated cell/particle size/count analysis method |
|
|
Sysmex, F-800 type |
|
78369 |
1498 |
| GK/Slc |
plasma glucose level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood glucose amount |
male |
70.0 days
| 6 |
|
250.0 |
mg/dl |
8.16 |
20.0 |
automated plasma analysis |
|
|
PMID:15591307 |
|
78382 |
1498 |
| GK/Slc |
plasma low density lipoprotein cholesterol level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood LDL cholesterol amount |
male |
70.0 days
| 6 |
|
11.0 |
mg/dl |
0.82 |
2.0 |
automated plasma analysis |
|
|
PMID:15591307 |
|
78385 |
1498 |
| GK/Slc |
plasma urea nitrogen level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood urea nitrogen amount |
male |
70.0 days
| 6 |
|
4.89 |
mmol/l |
0.39 |
0.96 |
automated plasma analysis |
|
|
PMID:15591307 |
|
78388 |
1498 |
| GK/Slc |
plasma creatinine level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood creatinine amount |
male |
70.0 days
| 6 |
|
0.2 |
mg/dl |
0.01 |
0.02 |
automated plasma creatinine analysis |
|
|
Hitachi, model 7170 |
|
78389 |
1498 |
| GK/Slc |
plasma potassium level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood potassium amount |
male |
70.0 days
| 6 |
|
4.11 |
mmol/l |
0.31 |
0.75 |
automated blood electrolyte analysis |
|
|
Analytical intruments, PVA alpha II |
|
78393 |
1498 |
| GK/Slc |
blood basophil count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
basophil quantity |
male |
70.0 days
| 6 |
|
0.0 |
% |
0.0 |
0.0 |
automated differential white blood cell count test |
|
|
May-Giemsa staining |
|
78395 |
1498 |
| GK/Slc |
urine sodium level |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine sodium amount |
male |
63.0 days
| 6 |
|
139.1 |
mmol/l |
4.65 |
11.4 |
automated urine analysis |
|
|
Analytical intruments, PVA alpha II |
|
95206 |
1662 |
| GK/Slc |
urine potassium excretion rate to body weight ratio |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine potassium amount |
male |
63.0 days
| 6 |
|
182.0 |
uEq/100g/6 hrs |
5.72 |
14.0 |
automated urine analysis |
|
|
Analytical intruments, PVA alpha II |
|
95209 |
1662 |
| GK/Slc |
blood hemoglobin A1c level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood hemoglobin amount |
male |
105.0 days
| |
|
5.21 |
% |
0.12 |
|
blood hemoglobin analysis |
0.0 |
|
|
HbA1c n=4-6 |
102880 |
2781 |
| GK/Slc |
blood triglyceride level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood triglyceride amount |
male |
105.0 days
| |
|
52.3 |
mg/dl |
7.4 |
|
blood triglyceride analysis |
0.0 |
|
|
n=4-6 |
102888 |
2781 |
| GK/Slc |
timed urine volume |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
urine output |
male |
105.0 days
| |
|
9.6 |
ml/d |
0.7 |
|
urine volume measurement method |
0.0 |
|
|
n=4-6 |
102924 |
2781 |
| GK/Slc |
body weight |
specific pathogen-free condition |
NBRP Body Weight data |
body mass |
male |
70.0 days
| 6 |
|
245.0 |
g |
3.88 |
9.5 |
whole body digital scale |
|
|
|
|
70810 |
21 |
| GK/Slc |
platelet count |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
platelet quantity |
male |
70.0 days
| 6 |
|
709.0 |
x 1000 /ul |
27.35 |
67.0 |
automated cell/particle size/count analysis method |
|
|
Sysmex, F-800 type |
|
78373 |
1498 |
| GK/Slc |
plasma high density lipoprotein cholesterol level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood HDL cholesterol amount |
male |
70.0 days
| 6 |
|
66.8 |
mg/dl |
0.45 |
1.1 |
automated plasma analysis |
|
|
PMID:15591307 |
|
78384 |
1498 |
| GK/Slc |
plasma total bilirubin level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood bilirubin amount |
male |
70.0 days
| 6 |
|
0.08 |
mg/dl |
0.0 |
0.01 |
automated plasma analysis |
|
|
PMID:15591307 |
total plasma bilirubin level |
78387 |
1498 |
| GK/Slc |
plasma sodium level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood sodium amount |
male |
70.0 days
| 6 |
|
144.7 |
mmol/l |
0.61 |
1.5 |
automated blood electrolyte analysis |
|
|
Analytical intruments, PVA alpha II |
|
78392 |
1498 |
| GK/Slc |
plasma phosphate level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood phosphate amount |
male |
70.0 days
| 6 |
|
6.5 |
mg/dl |
0.2 |
0.5 |
automated blood electrolyte analysis |
|
|
Hitachi, model 7170 |
|
78390 |
1498 |
| GK/Slc |
blood segmented neutrophil count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
neutrophil quantity |
male |
70.0 days
| 6 |
|
12.0 |
% |
1.22 |
3.0 |
automated differential white blood cell count test |
|
|
May-Giemsa staining |
segmented neutrophil % |
78398 |
1498 |
| GK/Slc |
timed urine volume |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine output |
male |
63.0 days
| 6 |
|
30.68 |
ml/d |
2.16 |
5.28 |
metabolic cage urine volume measurement method |
|
|
|
|
95204 |
1662 |
| GK/Slc |
urine sodium excretion rate to body weight ratio |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine sodium amount |
male |
63.0 days
| 6 |
|
0.01 |
uEq/min/g |
0.0 |
0.0 |
automated urine analysis |
|
|
Analytical intruments, PVA alpha II |
|
95207 |
1662 |
| GK/Slc |
timed urine volume to body weight ratio |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine output |
male |
63.0 days
| 6 |
|
0.08 |
ul/min/g |
0.01 |
0.01 |
metabolic cage urine volume measurement method |
|
|
|
|
95205 |
1662 |
| GK/Slc |
urine chloride level |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine chloride amount |
male |
63.0 days
| 6 |
|
142.0 |
mEq/L |
6.94 |
17.0 |
automated urine analysis |
|
|
|
|
95210 |
1662 |
| GK/Slc |
blood free fatty acids level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood free fatty acid amount |
male |
105.0 days
| |
|
21.51 |
mg/dl |
4.26 |
|
blood free fatty acid analysis |
0.0 |
|
|
ueq/l = umol/l |
102885 |
2781 |
| GK/Slc |
blood triglyceride level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood triglyceride amount |
male |
105.0 days
| |
|
31.0 |
mg/dl |
3.9 |
|
blood triglyceride analysis |
0.0 |
|
|
n=4-6 |
102889 |
2781 |
| GK/Slc |
blood total cholesterol level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood cholesterol amount |
male |
105.0 days
| |
|
77.8 |
mg/dl |
5.2 |
|
blood cholesterol analysis |
0.0 |
|
|
n=4-6 |
102892 |
2781 |
| GK/Slc |
blood low density lipoprotein cholesterol level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood LDL cholesterol amount |
male |
105.0 days
| |
|
24.3 |
mg/dl |
1.8 |
|
blood low-density lipoprotein-cholesterol measurement test |
0.0 |
|
|
n=4-6 |
102900 |
2781 |
| GK/Slc |
blood creatinine level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood creatinine amount |
male |
105.0 days
| |
|
0.24 |
mg/dl |
0.0 |
|
blood creatinine analysis |
0.0 |
|
|
n=4-6 |
102909 |
2781 |
| GK/Slc |
urine acetoacetate level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
urine ketone body amount |
male |
105.0 days
| |
|
91.5 |
umol/l |
39.9 |
|
urine analysis |
0.0 |
|
|
n=4-6 |
102916 |
2781 |
| GK/Slc |
timed urine volume |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
urine output |
male |
105.0 days
| |
|
29.3 |
ml/d |
3.6 |
|
urine volume measurement method |
0.0 |
|
|
n=4-6 |
102925 |
2781 |
| GK/Slc |
urine glucose level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
urine glucose amount |
male |
105.0 days
| |
|
9401.0 |
mg/dl |
1647.7 |
|
blood glucose test strip read by electrochemical glucometer |
0.0 |
|
|
n=4-6 |
102929 |
2781 |
| GK/Slc |
heart wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
heart mass |
male |
70.0 days
| 6 |
|
0.97 |
g |
0.02 |
0.05 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72227 |
41 |
| GK/Slc |
liver wet weight |
specific pathogen-free condition |
NBRP Organ Weight data |
liver mass |
male |
70.0 days
| 6 |
|
8.7 |
g |
0.27 |
0.67 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72231 |
41 |
| GK/Slc |
spleen weight to body weight ratio |
specific pathogen-free condition |
NBRP Organ Weight data |
spleen mass |
male |
70.0 days
| 6 |
|
0.22 |
% |
0.01 |
0.02 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72238 |
41 |
| GK/Slc |
both testes wet weight to body weight ratio |
specific pathogen-free condition |
NBRP Organ Weight data |
testis mass |
male |
70.0 days
| 6 |
|
0.92 |
% |
0.02 |
0.06 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72240 |
41 |
| GK/Slc |
blood hemoglobin level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood hemoglobin amount |
male |
70.0 days
| 6 |
|
16.6 |
g/dl |
0.2 |
0.5 |
automated cell/particle size/count analysis method |
|
|
Sysmex, F-800 type |
|
78367 |
1498 |
| GK/Slc |
mean corpuscular hemoglobin concentration |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood hemoglobin amount |
male |
70.0 days
| 6 |
|
30.2 |
g/dl |
0.16 |
0.4 |
automated cell/particle size/count analysis method |
|
|
Sysmex, F-800 type |
|
78371 |
1498 |
| GK/Slc |
plasma alkaline phosphatase activity level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood alkaline phosphatase amount |
male |
70.0 days
| 6 |
|
453.0 |
IU/l |
9.39 |
23.0 |
automated plasma analysis |
|
|
PMID:15591307 |
|
78378 |
1498 |
| GK/Slc |
plasma albumin level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood albumin amount |
male |
70.0 days
| 6 |
|
0.42 |
g/l |
0.01 |
0.02 |
automated plasma albumin analysis |
|
|
Hitachi, model 7170 |
|
78380 |
1498 |
| GK/Slc |
plasma albumin to plasma total protein ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood albumin amount |
male |
70.0 days
| 6 |
|
1.82 |
null |
0.06 |
0.15 |
automated plasma protein analysis |
|
|
Hitachi, model 7170 |
plasma albumin to plasma total protein ratio |
78381 |
1498 |
| GK/Slc |
plasma chloride level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood chloride amount |
male |
70.0 days
| 6 |
|
105.0 |
mmol/l |
0.41 |
1.0 |
automated blood electrolyte analysis |
|
|
Analytical intruments, PVA alpha II |
|
78394 |
1498 |
| GK/Slc |
total plasma calcium level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood calcium amount |
male |
70.0 days
| 6 |
|
10.0 |
mg/dl |
0.08 |
0.2 |
automated blood electrolyte analysis |
|
|
Hitachi, model 7170 |
|
78391 |
1498 |
| GK/Slc |
blood band neutrophil count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
neutrophil quantity |
male |
70.0 days
| 6 |
|
0.0 |
% |
0.0 |
0.0 |
automated differential white blood cell count test |
|
|
May-Giemsa staining |
band neutrophil % |
78397 |
1498 |
| GK/Slc |
blood monocyte count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
monocyte quantity |
male |
70.0 days
| 6 |
|
0.0 |
% |
0.0 |
0.0 |
automated differential white blood cell count test |
|
|
May-Giemsa staining |
|
78400 |
1498 |
| GK/Slc |
urine chloride excretion rate to body weight ratio |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine chloride amount |
male |
63.0 days
| 6 |
|
377.0 |
uEq/100g/6 hrs |
15.92 |
39.0 |
automated urine analysis |
|
|
|
|
95211 |
1662 |
| GK/Slc |
systolic blood pressure |
specific pathogen-free condition |
NBRP Blood Pressure and Heart Rate data |
arterial blood pressure trait |
male |
56.0 days-70.0 days |
6 |
serial mean |
130.0 |
mmHg |
4.49 |
11.0 |
tail cuff photoplethysmography |
|
|
NP-NIBP Monitor MK-2000, Muromachi Kikai Co., Ltd, Japan |
|
75063 |
14 |
| GK/Slc |
blood glycated albumin level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood albumin amount |
male |
105.0 days
| |
|
2.3 |
% |
0.07 |
|
blood protein analysis |
0.0 |
|
|
glycated albumin n=4-6 |
102876 |
2781 |
| GK/Slc |
blood glycated albumin level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood albumin amount |
male |
105.0 days
| |
|
1.9 |
% |
0.09 |
|
blood protein analysis |
0.0 |
|
|
glycated albumin n=4-6 |
102877 |
2781 |
| GK/Slc |
blood free fatty acids level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood free fatty acid amount |
male |
105.0 days
| |
|
12.55 |
mg/dl |
0.52 |
|
blood free fatty acid analysis |
0.0 |
|
|
ueq/l = umol/l |
102884 |
2781 |
| GK/Slc |
blood hemoglobin A1c level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood hemoglobin amount |
male |
105.0 days
| |
|
5.47 |
% |
0.03 |
|
blood hemoglobin analysis |
0.0 |
|
|
HbA1c n=4-6 |
102881 |
2781 |
| GK/Slc |
blood total cholesterol level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood cholesterol amount |
male |
105.0 days
| |
|
78.8 |
mg/dl |
3.8 |
|
blood cholesterol analysis |
0.0 |
|
|
n=4-6 |
102893 |
2781 |
| GK/Slc |
blood urea nitrogen level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood urea nitrogen amount |
male |
105.0 days
| |
|
16.1 |
mg/dl |
1.0 |
|
blood urea nitrogen analysis |
0.0 |
|
|
n=4-6 |
102905 |
2781 |
| GK/Slc |
blood creatinine level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood creatinine amount |
male |
105.0 days
| |
|
0.26 |
mg/dl |
0.02 |
|
blood creatinine analysis |
0.0 |
|
|
n=4-6 |
102908 |
2781 |
| GK/Slc |
lung weight to body weight ratio |
specific pathogen-free condition |
NBRP Organ Weight data |
lung mass |
male |
70.0 days
| 6 |
|
0.35 |
% |
0.01 |
0.02 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72230 |
41 |
| GK/Slc |
both kidneys wet weight as percentage of body weight |
specific pathogen-free condition |
NBRP Organ Weight data |
kidney mass |
male |
70.0 days
| 6 |
|
0.75 |
% |
0.03 |
0.08 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72234 |
41 |
| GK/Slc |
both adrenal glands weight to body weight ratio |
specific pathogen-free condition |
NBRP Organ Weight data |
adrenal gland mass |
male |
70.0 days
| 6 |
|
13.1 |
mg/100g |
0.9 |
2.2 |
Shimadzu electronic balance post excision weight measurement |
|
|
|
|
72236 |
41 |
| GK/Slc |
prothrombin time |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood coagulation trait |
male |
70.0 days
| 6 |
|
13.7 |
s |
0.16 |
0.4 |
automated coagulometer method |
|
|
Sysmex, CA-3000 type |
|
78374 |
1498 |
| GK/Slc |
plasma triglyceride level |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
blood triglyceride amount |
male |
70.0 days
| 6 |
|
0.67 |
mmol/l |
0.07 |
0.18 |
automated plasma analysis |
|
|
PMID:15591307 |
|
78386 |
1498 |
| GK/Slc |
blood lymphocyte count to total leukocyte count ratio |
fasting (for 16 hours) |
NBRP Hematology & Blood Biochemistry data |
lymphocyte quantity |
male |
70.0 days
| 6 |
|
87.0 |
% |
1.22 |
3.0 |
automated differential white blood cell count test |
|
|
May-Giemsa staining |
|
78399 |
1498 |
| GK/Slc |
urine potassium level |
0.9% sodium chloride solution (25 ml/kg) |
NBRP Urine Volume and Urine Electrolyte data |
urine potassium amount |
male |
63.0 days
| 6 |
|
68.6 |
mmol/l |
3.84 |
9.4 |
automated urine analysis |
|
|
Analytical intruments, PVA alpha II |
|
95208 |
1662 |
| GK/Slc |
heart rate |
specific pathogen-free condition |
NBRP Blood Pressure and Heart Rate data |
heart pumping trait |
male |
56.0 days-70.0 days |
6 |
serial mean |
446.0 |
beats/min |
15.51 |
38.0 |
tail cuff photoplethysmography |
|
|
NP-NIBP Monitor MK-2000, Muromachi Kikai Co., Ltd, Japan |
|
75064 |
14 |
| GK/Slc |
blood low density lipoprotein cholesterol level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
blood LDL cholesterol amount |
male |
105.0 days
| |
|
29.0 |
mg/dl |
2.1 |
|
blood low-density lipoprotein-cholesterol measurement test |
0.0 |
|
|
n=4-6 |
102901 |
2781 |
| GK/Slc |
urine 3-hydroxybutyrate level |
vehicle control condition (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
urine ketone body amount |
male |
105.0 days
| |
|
323.3 |
umol/l |
92.7 |
|
urine analysis |
0.0 |
|
|
n=4-6 |
102920 |
2781 |
| GK/Slc |
urine acetoacetate level |
controlled ipragliflozin content diet (0.008 %) (for 21 days) |
Iuchi H, et al., Sci Rep. 2017 Sep 19;7(1):11906. doi: 10.1038/s41598-017-12106-y. |
urine ketone body amount |
male |
105.0 days
| |
|
321.5 |
umol/l |
74.8 |
|
urine analysis |
0.0 |
|
|
n=4-6 |
102917 |
2781 |