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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
Atg12 ligase activity 
Atg8-family ligase activity  
FAT10 ligase activity 
ISG15 ligase activity 
NEDD8 ligase activity  
Pup ligase activity 
SUMO ligase activity +   
ubiquitin conjugating enzyme activity  
ubiquitin protein ligase activity +   
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
UFM1 ligase activity  
URM1 ligase activity 

Synonyms
Exact Synonyms: protein ubiquitination activity ;   ubiquitin ligase activity
Related Synonyms: E3 ;   ER-associated E3 ligase
Alternate IDs: GO:0090302 ;   GO:0090622 ;   GO:1904264 ;   GO:1904822
Xrefs: Reactome:R-HSA-183036 "Ubiquitination of stimulated EGFR (CBL:GRB2)" ;   Reactome:R-HSA-9008479 "FBXW7 polyubiquitinates RUNX2" ;   Reactome:R-HSA-9685195 "SARS-CoV-1 9b recruits ITCH to MAVS" ;   Reactome:R-HSA-9686920 "PELI1 ubiquitinates RIPK3 at K363" ;   Reactome:R-HSA-9686969 "APC/C:Cdh1 polyubiquitinates SKP2" ;   Reactome:R-HSA-9705738 "SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7" ;   Reactome:R-HSA-9706354 "Ubiquitination of FLT3" ;   Reactome:R-HSA-9706356 "CBL mutants don't ubiquitinate FLT3" ;   Reactome:R-HSA-9708517 "FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))" ;   Reactome:R-HSA-9733316 "p-Y-CBL autoubiquitinates and multiubiquitinates p-Y561-CSF1R in CSF1 dimer:p-Y561-CSF1R dimer:p-Y-CBL" ;   Reactome:R-HSA-9755304 "MUL1 ubiquitinates UBXN7" ;   Reactome:R-HSA-9755505 "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2" ;   Reactome:R-HSA-9759154 "TRIM21 ubiquitinates SQSTM1" ;   Reactome:R-HSA-9759172 "KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer" ;   Reactome:R-HSA-9762091 "NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1" ;   Reactome:R-HSA-9766645 "CUL3:RBX1 ubiquitinates KEAP1" ;   Reactome:R-HSA-990526 "Recruitment of ITCH and K48 ubiquitination of MAVS" ;   reactome:R-HSA-1225956 "Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL" ;   reactome:R-HSA-1504190 "DVL is ubiquitinated by CUL3:KLHL12:RBX1" ;   reactome:R-HSA-201445 "Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8" ;   reactome:R-HSA-3322429 "XIAP monoubiquinates TLE" ;   reactome:R-HSA-3640861 "RNF146 ubiquitinates ADP-ribosylated AXIN" ;   reactome:R-HSA-4608852 "SMURF1/2 ubiquitinates PRICKLE1" ;   reactome:R-HSA-4641129 "AXIN is ubiquitinated by SMURF2" ;   reactome:R-HSA-4641159 "DVL1 is ubiquitinated by HECW1" ;   reactome:R-HSA-4641246 "ZNRF3 autoubiquitinates to promote its internalization" ;   reactome:R-HSA-4641253 "ZNRF3 ubiquitinates FZD to promote its downregulation" ;   reactome:R-HSA-5246693 "APC is K63-polyubiquitinated" ;   reactome:R-HSA-5610737 "NUMB:ITCH bind and ubiquitnate GLI1" ;   reactome:R-HSA-5632648 "SMURF1/2 ubiquitinates PTCH1" ;   reactome:R-HSA-5635856 "SPOP:CUL3:RBX1 ubiquitinates GLI2,3" ;   reactome:R-HSA-5635864 "NUMB:ITCH ubiquitinates GLI1" ;   reactome:R-HSA-5654672 "CBL ubiquitinates FRS2 and FGFR1" ;   reactome:R-HSA-5654677 "CBL ubiquitinates FRS2 and FGFR2" ;   reactome:R-HSA-5654679 "CBL ubiquitinates FRS2 and FGFR3" ;   reactome:R-HSA-5654684 "CBL ubiquitinates FRS2 and FGFR4" ;   reactome:R-HSA-5658424 "KBTBD7:CUL3:RBX1 ubiquitinates NF1" ;   reactome:R-HSA-5674022 "BRAP autoubiquitinates" ;   reactome:R-HSA-5682858 "RNF8 and RNF168 ubiquitinate H2AFX" ;   reactome:R-HSA-5684071 "RNF4 ubiquitinates MDC1" ;   reactome:R-HSA-5687081 "MAPK6 is ubiquitinated at the N-terminal" ;   reactome:R-HSA-5689111 "PARK2 autoubiquitinates" ;   reactome:R-HSA-5690827 "TNFAIP3 (A20) ubiquitinates RIPK1" ;   reactome:R-HSA-6781867 "ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II" ;   reactome:R-HSA-6782943 "UV-DDB ubiquitinates XPC" ;   reactome:R-HSA-6785361 "Monoubiquitination of FANCD2:FANCI" ;   reactome:R-HSA-6790487 "RNF111 ubiquitinates SUMOylated XPC" ;   reactome:R-HSA-6798373 "MDM2 ubiquitinates DYRK2" ;   reactome:R-HSA-6804253 "MDM2 ubiquitinates JMY" ;   reactome:R-HSA-6804441 "RNF34 or RFFL ubiquitinates phosphorylated TP53" ;   reactome:R-HSA-6804724 "MDM2 ubiquitinates phosphorylated MDM4" ;   reactome:R-HSA-6804879 "MDM2 ubiquitinates TP53" ;   reactome:R-HSA-6804942 "MDM2 homodimers auto-ubiquitinate" ;   reactome:R-HSA-6807106 "PTEN undergoes monoubiquitination" ;   reactome:R-HSA-6807134 "NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN" ;   reactome:R-HSA-68946 "Phosphorylated Orc1 is ubiquitinated while still associated with chromatin" ;   reactome:R-HSA-69015 "Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex" ;   reactome:R-HSA-8848829 "CBL autoubiquitinates" ;   reactome:R-HSA-8851011 "TRIM27 polyubiquitinates PTEN" ;   reactome:R-HSA-8854041 "SCF-FBXL7 ubiquitinates AURKA" ;   reactome:R-HSA-8854051 "SCF-FBXL18 ubiquitinates FBXL7" ;   reactome:R-HSA-8854628 "MYLIP dimer ubiquitinates VLDLR on Lys-839" ;   reactome:R-HSA-8866546 "RNF5 and RNF185 ubiquitinate misfolded CFTR" ;   reactome:R-HSA-8866856 "RNF5 and RNF185 ubiquitinate CFTR F508del" ;   reactome:R-HSA-8867288 "OS9:SEL1:ERAD E3 ligase:DERL2 ubiquitinates unfolded protein:(GlcNAc)2 (Man)9-5" ;   reactome:R-HSA-8875183 "CBL monoubiquitinates activated MET" ;   reactome:R-HSA-8875431 "LRIG1 undergoes ubiquitination" ;   reactome:R-HSA-8876258 "CBL monoubiquitinates InlB-bound MET" ;   reactome:R-HSA-8877003 "CBLL1 ubiqutinates the InlA-bound CDH1 complex" ;   reactome:R-HSA-8938773 "RNF144A polyubiquitinates PRKDC" ;   reactome:R-HSA-8938815 "RNF152 polyubiquitinates RRAGA" ;   reactome:R-HSA-8939335 "RNF181 polyubiquinates BCL10" ;   reactome:R-HSA-8939706 "SCF(SKP2) polyubiquitinates RUNX2" ;   reactome:R-HSA-8942101 "RNF20:RNF40 monoubiquitinates Histone H2B" ;   reactome:R-HSA-8943003 "SHPRH polyubiquitinates monoubiquitinated PCNA" ;   reactome:R-HSA-8943040 "HLTF polyubiquitinates monoubiquitinated PCNA" ;   reactome:R-HSA-8943080 "TMEM129 polyubiquitinates HLA (MHC class I heavy chain) bound to cytomegalovirus US11" ;   reactome:R-HSA-8948775 "MKRN1 polyubiquitinates PTEN" ;   reactome:R-HSA-8948832 "RNF146 polyubiquitinates PARylated PTEN" ;   reactome:R-HSA-8952382 "MDM2 polyubiquitinates RUNX3" ;   reactome:R-HSA-8952419 "SMURFs ubiquitinate RUNX3" ;   reactome:R-HSA-8953946 "PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11" ;   reactome:R-HSA-8956026 "CUL9:RBX1 ubiquitinates BIRC5" ;   reactome:R-HSA-8956684 "ITCH polyubiquitinates TP73" ;   reactome:R-HSA-9008076 "WWP1 polyubiquitinates RUNX2" ;   reactome:R-HSA-9009308 "STUB1 polyubiquitinates RUNX2" ;   reactome:R-HSA-9009403 "SMURF1 polyubiquitinates RUNX2" ;   reactome:R-HSA-9011300 "ZSWIM8 ubiquitinates ROBO3.1" ;   reactome:R-HSA-9021523 "WWP2 ubiquitinates NOTCH3" ;   reactome:R-HSA-9033485 "PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11" ;   reactome:R-HSA-934604 "Phosphorylated SPRY2 is ubiquitinated by CBL" ;   reactome:R-HSA-936462 "PIN1 mediated IRF3 degradation" ;   reactome:R-HSA-936475 "Negative regulation of DDX58/IFIH1 signaling by RNF216" ;   reactome:R-HSA-9604629 "FBXW7 promotes ubiquitination of p-NICD4"
Definition Sources: GOC:BioGRID, GOC:dph, GOC:mah, GOC:tb, PMID:22863777

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