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ONTOLOGY REPORT - ANNOTATIONS

Term:ubiquitin-ubiquitin ligase activity
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Accession:GO:0034450 term browser browse the term
Definition:Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue.
Synonyms:exact_synonym: E4
 xref: reactome:R-HSA-937050 "Pellino ubiquitinates hp-IRAK1";   reactome:R-HSA-975122 "Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
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show annotations for term's descendants           Sort by:
ubiquitin-ubiquitin ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor enables ISO (PMID:24810856) RGD PMID:24810856 NCBI chr19:10,996,705...11,032,260
Ensembl chr19:10,996,099...11,032,247 		JBrowse link
G Anapc11 anaphase promoting complex subunit 11 enables ISO (PMID:10230407) RGD PMID:10230407 NCBI chr10:105,875,209...105,886,307 JBrowse link
G Peli1 pellino E3 ubiquitin protein ligase 1 enables ISO (PMID:30952868) RGD PMID:30952868 NCBI chr14:95,254,274...95,309,168
Ensembl chr14:95,254,589...95,308,285 		JBrowse link
G Ppil2 peptidylprolyl isomerase like 2 enables ISO (PMID:11435423) RGD PMID:11435423 NCBI chr11:83,897,719...83,920,970
Ensembl chr11:83,897,764...83,922,144 		JBrowse link
G Prpf19 pre-mRNA processing factor 19 enables ISO
IEA		 (PMID:11435423)
GO_REF:0000107		 RGD
Ensembl		 PMID:11435423 GO_REF:0000107 NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662 		JBrowse link
G Rbx1 ring-box 1 enables ISO (PMID:10230407) RGD PMID:10230407 NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 enables ISO (PMID:11435423) RGD PMID:11435423 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
G Traf6 TNF receptor associated factor 6 enables IEA
ISO		 GO_REF:0000107
(PMID:15465037)		 Ensembl
RGD		 PMID:15465037 GO_REF:0000107 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K enables ISO (PMID:17873885) RGD PMID:17873885 NCBI chr14:42,658,016...42,718,899
Ensembl chr14:42,658,016...42,718,630 		JBrowse link
G Ube4a ubiquitination factor E4A enables IEA
IBA
ISO		 GO_REF:0000104
GO_REF:0000033
(PMID:11435423)		 UniProt
GO_Central
RGD		 PMID:11435423 GO_REF:0000033 GO_REF:0000104 NCBI chr 8:45,236,022...45,278,129
Ensembl chr 8:45,236,026...45,278,038 		JBrowse link
G Ube4b ubiquitination factor E4B enables IBA
ISO		 GO_REF:0000033
(PMID:11435423), (PMID:20017557)		 GO_Central
RGD		 PMID:11435423 PMID:20017557 GO_REF:0000033 NCBI chr 5:159,766,829...159,870,509
Ensembl chr 5:159,766,829...159,870,509 		JBrowse link
G Ubox5 U-box domain containing 5 enables IBA
ISO		 GO_REF:0000033
(PMID:11435423)		 GO_Central
RGD		 PMID:11435423 GO_REF:0000033 NCBI chr 3:117,806,212...117,847,711
Ensembl chr 3:117,807,092...117,847,722 		JBrowse link
G Ubr5 ubiquitin protein ligase E3 component n-recognin 5 enables ISO
IEA
IBA		 (PMID:21118991)
GO_REF:0000107
GO_REF:0000118
GO_REF:0000033		 RGD
Ensembl
TreeGrafter
GO_Central		 PMID:21118991 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:69,115,216...69,224,843
Ensembl chr 7:69,116,761...69,224,903 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20890
    catalytic activity 6118
      catalytic activity, acting on a protein 2496
        ubiquitin-like protein transferase activity 472
          ubiquitin-protein transferase activity 443
            ubiquitin protein ligase activity 349
              ubiquitin-ubiquitin ligase activity 13
Path 2
Term Annotations click to browse term
  molecular_function 20890
    catalytic activity 6118
      transferase activity 2428
        acyltransferase activity 738
          aminoacyltransferase activity 488
            ubiquitin-like protein transferase activity 472
              ubiquitin-like protein ligase activity 368
                ubiquitin protein ligase activity 349
                  ubiquitin-ubiquitin ligase activity 13
paths to the root