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Pathways
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Ontology Browser
Term:
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)
Annotations: Rat: (24) Mouse: (26) Human: (30) Chinchilla: (22) Bonobo: (24) Dog: (23) Squirrel: (24) Pig: (21) Naked Mole-rat: (20) Green Monkey: (24)
Parent Terms Term With Siblings Child Terms
cGAS/STING signaling pathway +   
endolysosomal toll-like receptor signaling pathway +   
endosomal pattern recognition receptor signaling pathway 
inflammasome-mediated signaling pathway +   
MDA-5 signaling pathway +   
negative regulation of cytoplasmic pattern recognition receptor signaling pathway +   
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway +   
The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number.
regulation of cytoplasmic pattern recognition receptor signaling pathway +   
RIG-I signaling pathway +   

Synonyms
Exact Synonyms: NLR signaling pathway ;   nucleotide-binding domain, leucine rich repeat containing receptor signal transduction ;   nucleotide-binding domain, leucine rich repeat containing receptor signal transduction pathway ;   nucleotide-binding domain, leucine rich repeat containing receptor signalling pathway
Related Synonyms: NOD-like receptor signaling pathway
Definition Sources: GOC:sj, PMID:18280719, PMID:32838963, PMID:36973360

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