| Parent Terms |
Term With Siblings |
Child Terms |
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1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity
1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity
1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity
1-hydroxy-2-naphthoate 1,2-dioxygenase activity
2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity
2,2',3-trihydroxybiphenyl dioxygenase activity
2,3-dihydroxy DDT 1,2-dioxygenase activity
2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity
2,3-dihydroxy-p-cumate dioxygenase activity
2,3-dihydroxybenzoate 2,3-dioxygenase activity
2,3-dihydroxybenzoate 3,4-dioxygenase activity
2,3-dihydroxybiphenyl 1,2-dioxygenase activity
2,3-dihydroxydiphenyl ether dioxygenase activity
2,3-dihydroxyindole 2,3-dioxygenase activity
2,4'-dihydroxyacetophenone dioxygenase activity
2,5-dihydroxypyridine 5,6-dioxygenase activity
2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity
2-aminophenol 1,6-dioxygenase activity
2-mercaptobenzothiazole dioxygenase activity
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase activity
3,4-dihydroxyphenanthrene dioxygenase activity
3,4-dihydroxyphenylacetate 2,3-dioxygenase activity
3,5-dichlorocatechol 1,2-dioxygenase activity
3-carboxyethylcatechol 2,3-dioxygenase activity
3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity
3-hydroxy-2-naphthoate 2,3-dioxygenase activity
3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity
3-hydroxyanthranilate 3,4-dioxygenase activity
4,5-dihydroxybenzo(a)pyrene dioxygenase activity
4,5-dihydroxypyrene dioxygenase activity
4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity
4-hydroxycatechol 1,2-dioxygenase activity
4-hydroxymandelate synthase activity
4-hydroxyphenylpyruvate dioxygenase activity
5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity
5,6-dimethylbenzimidazole synthase activity
5-aminosalicylate dioxygenase activity
7,8-dihydroxy benzo(a)pyrene dioxygenase activity
7,8-dihydroxykynurenate 8,8a-dioxygenase activity
9,10-dihydroxybenzo(a)pyrene dioxygenase activity
9-cis-10'-apo-beta-carotenal cleavage oxygenase activity
9-cis-beta-carotene 9',10'-cleavage oxygenase activity
acetylacetone-cleaving enzyme activity
acireductone dioxygenase (Ni2+-requiring) activity
acireductone dioxygenase [iron(II)-requiring] activity
all-trans-8'-apo-beta-carotenal 15,15'-oxygenase activity
all-trans-beta-apo-10'-carotenal cleavage oxygenase activity
arachidonate 12(R)-lipoxygenase activity
arachidonate 12(S)-lipoxygenase activity
arachidonate 15-lipoxygenase activity
arachidonate 5-lipoxygenase activity Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate.
arachidonate 8(R)-lipoxygenase activity
arachidonate 8(S)-lipoxygenase activity
benzo(a)pyrene 11,12-dioxygenase activity
benzo(a)pyrene 4,5-dioxygenase activity
benzo(a)pyrene 7,8-dioxygenase activity
benzo(a)pyrene 9,10-dioxygenase activity
beta,beta-carotene-9',10'-cleaving oxygenase activity
beta-carotene 15,15'-dioxygenase activity
biphenyl-2,3-diol 1,2-dioxygenase activity
caffeate 3,4-dioxygenase activity
carbazole 1,9a-dioxygenase activity
carotenoid dioxygenase activity +
catechol dioxygenase activity +
chloridazon-catechol dioxygenase activity
chlorite O2-lyase activity
chlorocatechol 1,2-dioxygenase activity
cysteamine dioxygenase activity
cysteine dioxygenase activity
dihydroxydibenzothiophene dioxygenase activity
dihydroxyfluorene dioxygenase activity +
diphenyl ether 1,2-dioxygenase activity
fatty acid alpha-oxygenase activity
gallate dioxygenase activity
gentisate 1,2-dioxygenase activity
homogentisate 1,2-dioxygenase activity
hydroquinone 1,2-dioxygenase activity
hydroxyquinol 1,2-dioxygenase activity
indole 2,3-dioxygenase activity
indoleamine 2,3-dioxygenase activity
lignostilbene alpha beta-dioxygenase activity
linoleate 11-lipoxygenase activity
linoleate 13S-lipoxygenase activity
linoleate 8R-lipoxygenase activity
linoleate 9R-lipoxygenase activity
linoleate 9S-lipoxygenase activity
linolenate 9R-lipoxygenase activity
lutein oxygenase activity
p-cumate 2,3-dioxygenase activity
phenanthrene dioxygenase activity
phenanthrene-4-carboxylate dioxygenase activity
protocatechuate 3,4-dioxygenase activity
protocatechuate 3,4-dioxygenase type II activity
protocatechuate 4,5-dioxygenase activity
pyrene dioxygenase activity
pyridine-3,4-diol dioxygenase activity
pyrogallol 1,2-oxygenase activity
quercetin 2,3-dioxygenase activity
stizolobate synthase activity
stizolobinate synthase activity
styrene dioxygenase activity
sulfur dioxygenase activity
sulfur oxygenase/reductase activity
tetrachlorobenzene dioxygenase activity
tryptophan 2,3-dioxygenase activity
violaxanthin oxygenase activity
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| Synonyms |
| Narrow Synonyms: |
LTA synthase activity
;
leukotriene-A(4) synthase activity
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| Broad Synonyms: |
leukotriene A4 synthase
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| Related Synonyms: |
5-delta-lipoxygenase activity
;
5-lipoxygenase activity
;
5Delta-lipoxygenase activity
;
C-5-lipoxygenase activity
;
arachidonate:oxygen 5-oxidoreductase activity
;
arachidonic 5-lipoxygenase activity
;
arachidonic acid 5-lipoxygenase activity
;
delta5-lipoxygenase activity
;
leukotriene-A4 synthase activity
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| Xrefs: |
EC:1.13.11.34
;
MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN
;
RHEA:32307
;
reactome:R-HSA-265296 "Arachidonic acid is oxidised to 5S-HpETE by ALOX5"
;
reactome:R-HSA-266051 "5S-HpETE is dehydrated to LTA4 by ALOX5"
;
reactome:R-HSA-9018858 "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE"
;
reactome:R-HSA-9018859 "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE"
;
reactome:R-HSA-9018863 "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE"
;
reactome:R-HSA-9018894 "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE"
;
reactome:R-HSA-9020251 "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA"
;
reactome:R-HSA-9020255 "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA"
;
reactome:R-HSA-9020256 "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA"
;
reactome:R-HSA-9020259 "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA"
;
reactome:R-HSA-9020264 "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA"
;
reactome:R-HSA-9020277 "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA"
;
reactome:R-HSA-9020278 "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA"
;
reactome:R-HSA-9020282 "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA"
;
reactome:R-HSA-9024997 "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA"
;
reactome:R-HSA-9025995 "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3"
;
reactome:R-HSA-9025996 "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3"
;
reactome:R-HSA-9025999 "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3"
;
reactome:R-HSA-9026005 "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA"
;
reactome:R-HSA-9026405 "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4"
;
reactome:R-HSA-9027624 "ALOX5 oxidises DHA to 7-HDHA"
;
reactome:R-HSA-9027628 "ALOX5 oxidises EPA to 5-HEPE"
;
reactome:R-HSA-9027633 "ALOX5 oxidises DPAn-3 to 7-HDPAn-3" |
| Definition Sources: |
EC:1.13.11.34, RHEA:32307 |
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